| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-19 | Jurkat, MOLT-4 | Up | CYLD | NF-Kappa B signaling pathway | hsa-miR-19 regulates the expression of CYLD and controls NF-Kappa B expression in downstream signaling pathway in T-cell acute lymphoblastic leukemia. | Ye et al., 2012 |
| hsa-miR-9 | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK6 | CDK pathway | CDK6 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the CDK6-RB1 oncogenic pathway in acute lymphoblastic leukemia. | Rodriguez-Otero et al., 2011 |
| hsa-miR-9 | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | FGFR1 | FGF signaling pathway | FGFR1 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the FGFR1 oncogenic pathway in acute lymphoblastic leukemia. | Rodriguez-Otero et al., 2011 |
| hsa-miR-150 | MOLT-3, Jurkat, CCRF-HSB-2 | Up | NOTCH3 | Notch signaling pathway | Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia. | Ghisi et al., 2011 |
| hsa-miR-451 | T-ALL cell lines | Down | MYC | Notch signaling pathway | hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia. | Li et al., 2011 |
| hsa-miR-124a | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK6 | CDK pathway | Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells. | Agirre et al., 2009 |