| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-181a | KG-1a, MV4-11, HL-60, HEK293T | Up | KRAS | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating KRAS and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| hsa-miR-181a | KG-1a, MV4-11, HL-60, HEK293T | Up | NRAS | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating NRAS and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| hsa-miR-181a | KG-1a, MV4-11, HL-60, HEK293T | Up | MAPK1 | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating MAPK1 and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| hsa-miR-27a | SKM-1 | Down | ABCB1 | NF-Kappa B signaling pathway | Downregulation of miRNA-27a is associated with upregulation of ABCB1 expression and this effect is linked with a switch between the canonical and non-canonical NF-kappaB pathways. | Messingerova et al., 2016 |
| hsa-miR-34b | HL-60, OCI-AML3 | Down | HSF1 | Wnt signaling pathway | MicroRNA-34b suppresses acute myeloid leukemia cell proliferation and survival by downregulating HSF1, in turn leading to the inactivation of Wnt signaling pathway. | Li et al., 2016 |
| hsa-miR-126 | Peripheral blood, bone marrow | Up | PI3K-Akt signaling pathway | miR-126 targets the PI3K-Akt signaling pathway, preserving acute myeloid leukemia stem cells quiescence and promoting chemotherapy resistance. | Lechman et al., 2016 |