| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-146a | SH-SY5Y | Up | LRP2 | PI3K-Akt signaling pathway | Upregulation of miRNA-146a significantly suppresses Lrp2 ( Low-density lipoprotein receptor-related protein-2) expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby enhancing cell apoptosis. | Zhang et al., 2016 |
| hsa-miR-34a | SH-SY5Y | Down | ERK pathway | MicroRNA-34a and its regulator TAp73 play an important role in tight regulation of the neuronal cell cycle via their ability to reduce cyclin D1. This balance is significantly altered when neurons encounter insults like A-beta-42, which aberrantly activates MEK-ERK signaling. | Modi et al., 2015 | |
| hsa-miR-138 | HEK293 | Up | RARA | GSK3 signaling pathway | MicroRNA-138 increases tau phosphorylation by targeting the RARA/GSK-3-beta pathway. | Wang et al., 2015 |
| hsa-miR-132 | Cerebral cortex | Down | PTEN | PI3K-Akt signaling pathway | MicroRNA-132 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| hsa-miR-132 | Cerebral cortex | Down | FOXO3A | FoxO signaling pathway | MicroRNA-132 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| hsa-miR-212 | Cerebral cortex | Down | PTEN | PI3K-Akt signaling pathway | MicroRNA-212 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| hsa-miR-212 | Cerebral cortex | Down | FOXO3A | FoxO signaling pathway | MicroRNA-212 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| hsa-miR-106b | SH-SY5Y | Up | TGF BETA R2 | TGF-beta signaling pathway | MicroRNA-106b is involved in the pathogenesis of alzheimer's disease by regulating the expression of TGF-beta type II receptor (T-beta R II), thereby influencing TGF-beta signaling. | Wang et al., 2010 |