| Non-Hodgkin lymphoma |
hsa-miR-181a |
SU-DHL-4, SU-DHL-10 |
Up |
BIM |
Ectopic suppression of miR-181a inhibits cell adhesion dependent Bim down-regulation, resulting in cell apoptosis. hsa-miR-181a plays a significant role in the regulation of lymphoma survival and cell adhesion regulated drug resistance. |
Lwin et al., 2010 |
| Chronic lymphocytic leukemia |
hsa-miR-15a |
Peripheral blood |
Down |
BCL2 |
miR-15a downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia. |
Cimmino et al., 2005 |
| Chronic lymphocytic leukemia |
hsa-miR-16-1 |
Peripheral blood |
Down |
BCL2 |
miR-16-1 downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia. |
Cimmino et al., 2005 |
| Influenza virus A infection |
hsa-miR-4276 |
Primary human bronchial epithelial cells |
Down |
COX6C |
COX6C is an apoptotic protein that when suppressed by over-expression of miRNA-4276, allows the influenza virus to replicate and spread to neighboring healthy cells. |
Othumpangat et al., 2014 |
| Cervical cancer |
hsa-miR-744 |
HeLa, C-4-1, Ca Ski, SiHa |
Up |
BCL 2 |
MicroRNA-744 suppresses the expression of Bcl-2, which leads to the inactivation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorating cervical cancer growth and progression. |
Chen et al., 2016 |
| Gastric cancer |
hsa-miR-18a |
MGC-803, HGC-27 |
Down |
HIF 1 ALPHA |
MicroRNA-18a induces gastric cancer cell apoptosis through the HIF-1-alpha/mitochondrial apoptosis pathway. |
Wu et al., 2015 |
| Gastric cancer |
hsa-miR-421 |
MGC-803, HGC-27, BGC-823, SGC-7901 |
Up |
CASPASE 3 |
MicroRNA-421 functions as a tumor promoter by down-regulating the caspase-3 and inhibiting apoptosis of gastric cancer cells via repression of caspase-3 expression. |
Wu et al., 2014 |
| Gastric cancer |
hsa-miR-106a |
Stomach |
Up |
FAS |
Upregulation of miR-106a functions as an oncogene in gastric carcinogenesis and impair Apoptosis pathway by inhibiting FAS. |
Wang et al., 2013 |
| Non-small cell lung cancer |
hsa-miR-3666 |
A-549 |
|
SIRT7 |
MicroRNA-3666 down-regulates the expression of SIRT7 and suppresses non-small cell lung cancer cell growth by inducing the Apoptosis pathway. |
Shi et al., 2016 |
| Non-small cell lung cancer |
hsa-miR-7 |
Lung |
|
SMARCD1 |
MicroRNA-7 suppresses p53-dependent apoptosis-related gene BAX (BCL2-associated X protein) and expression of p21 by interfering with the interaction between SMARCD1 and p53, thereby decreasing caspase3 cleavage and the downstream apoptosis cascades. |
Hong et al., 2016 |
| Prostate cancer |
hsa-miR-130a |
PC-3 |
Down |
SLAIN1 |
Ectopic expression of microRNA-130a activates apoptotic signaling pathway in taxane-resistant prostate cancer cells via activation of caspase-8. |
Fujita et al., 2015 |
| Laryngeal squamous cell carcinoma |
hsa-miR-221 |
HEp-2 |
Up |
APAF 1 |
MicroRNA-221 enhances the proliferation of laryngeal cancer cells by down-regulating Apaf-1 expression. |
Sun et al., 2015 |
| Alcoholic liver disease |
hsa-miR-21 |
Hepatic stellate cells |
Up |
FAS |
Downregulation of miR-21 increased the expression of FASL in alcoholic liver injury. |
Francis et al., 2014 |