Disease Name:

Breast Cancer

microRNA Score: 0.2672

Gene Score: 0.189

Pathway Score: 0.5082

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-373 MCF-7, MDA-MB-231, MDA-MB-435 Up TXNIP HIF1-alpha-TWIST signaling pathway MicroRNA-373 promotes the epithelial-to-mesenchymal transition and metastasis through the HIF1-alpha-TWIST signaling axis in breast cancer.
 Chen et al., 2015
hsa-miR-19a MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway Upregulation of hsa-miR-19a is associated with reduced expression of BRCA2 in breast cancer.
Mogilyansky et al., 2016
hsa-miR-19b MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway MicroRNA-19b directly inhibits the expression of BRCA2 in breast cancer.
 Mogilyansky et al., 2016
hsa-miR-223 MCF-7, MDA-MB-231, MDA-MB-435, SK-BR-3 Down HAX1 Mitochondria/ROS pathway MicroRNA-223 enhances the sensitivity of triple-negative breast cancer to TRAIL-induced apoptosis by down-regulating the expression of HAX-1.
 Sun et al., 2016
hsa-miR-421 Breast Down MTA1 miR-421/MTA1 pathway MicroRNA-421 inhibits breast cancer metastasis by down-regulating the expression of MTA1.
Pan et al., 2016
hsa-miR-34a Breast Down WNT 1 Wnt signaling pathway MicroRNA-34a inhibits the proliferation and progression of breast cancer through modulating the Wnt signaling pathway.
 Si et al., 2016
hsa-miR-29a Breast Up PTEN PI3K-Akt signaling pathway MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting PTEN in breast cancer cells.
 Shen et al., 2016
hsa-miR-29a Breast Up GSK 3 BETA PI3K-Akt signaling pathway MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting GSK3-beta in breast cancer cells.
 Shen et al., 2016
hsa-miR-10b Breast Up NF1 ROCK pathway MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting NF1.
 Knirsh et al., 2016
hsa-miR-10b Breast Up HOXD10 ROCK pathway MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting HOXD10.
 Knirsh et al., 2016
hsa-miR-493 Breast FUT4 miR-493-5p/FUT4 pathway MicroRNA-493 plays an important role in invasiveness and tumorigenicity of breast cancer cells via inhibiting FUT4 expression.
 Zhao et al., 2016
hsa-miR-320a Breast Down MTDH miR-320a/MTDH pathway MicroRNA-320a inhibits breast cancer metastasis by directly targeting MTDH.
 Yu et al., 2016
hsa-miR-124 Breast Down AKT Estrogen signaling pathway Upregulation of miR-124 inhibits tumor growth and angiogenesis in breast cancer by inhibiting AKT2 expression.
 Jiang et al., 2016
hsa-miR-489 Breast Down SPIN1 PI3K-Akt signaling pathway MicroRNA-489 reverses the chemoresistance of breast cancer through the PI3K-PI3K-Akt signaling pathway by inhibiting SPIN1 expression.
 Chen et al., 2016
hsa-miR-10b MCF-7,MDA-MB-231, SK-BR-3 Up PTEN PI3K-Akt signaling pathway MicroRNA-10b regulates the self-renewal of the breast cancer stem cell phenotype through PI3K-Akt signaling pathway by targeting PTEN.
 Bahena-Ocampo et al., 2016
hsa-miR-206 MCF-7,MDA-MB-231, ZR-75-1 TBX3 miR-206/Tbx3 signaling pathway MicroRNA-206 functions as a tumor suppressor and directly inhibits Tbx3 expression in breast cancer.
 Amir et al., 2016
hsa-miR-101 Breast Down EYA1 Notch signaling pathway MicroRNA-101 suppresses cell proliferation and promote apoptosis in breast cancer by down-regulating EYA1 via the Notch signaling pathway.
 Guan et al., 2016
hsa-miR-3646 Breast Up GSK 3 BETA Beta-catenin pathway MicroRNA-3646 promotes docetaxel resistance of breast cancer cells via inhibiting expression of GSK-3-beta and activating GSK-3-beta/beta-catenin signaling pathway.
 Zhang et al., 2016
hsa-miR-1229 Breast Up GSK 3 BETA Wnt signaling pathway MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway.
 Tan et al., 2016
hsa-miR-214 Breast Up PTEN PI3K-Akt signaling pathway MicroRNA-214 functions as oncogene in breast cancer by inhibiting the PI3K-Akt signaling pathway.
 Wang et al., 2016
hsa-miR-548j Breast TENSIN1 CDC42 pathway MicroRNA-548j acts as a metastasis-promoting miRNA to promote breast cancer cell invasion and metastasis by inhibiting Tensin1 expression.
 Zhan et al., 2016
hsa-miR-135b Breast LATS2 Hippo signaling pathway MicroRNA-135b directly targets large tumor suppressor kinase 2, a important component of the Hippo pathway.
 Hua et al., 2016
hsa-miR-498 MCF-7, MDA-MB-231, SK-BR-3 Up BRCA1 BRCA1 pathway Upregulation of miR-498 regulates the pathogenesis of sporadic triple negative breast cancer through BRCA1 downregulation.
 Matamala et al., 2016
hsa-miR-489 MCF-7 Down HER2 MAPK signaling pathway A double-negative feedback loop of miR-489 and the HER2-SHP2-MAPK signaling axis promotes breast cancer cell proliferation and tumor progression.
 Patel et al., 2016
hsa-miR-362 Breast Up CYLD NF-Kappa B signaling pathway MicroRNA-362 regulates breast cancer cell proliferation, migration and invasion through NF-Kappa B signaling pathway.
 Ni et al., 2016
hsa-miR-147 Breast Down mTOR pathway MicroRNA-147 inhibits the proliferation, invasion and migration of breast cancer cells through targeting the Akt/mTOR signaling pathway.
 Zhang et al., 2016
hsa-miR-302 Breast Down MEKK1 ERK pathway MicroRNA-302 sensitizes breast cancer cells to adriamycin through targeting P-glycoprotein by inhibiting MEKK1 of ERK pathway.
 Zhao et al., 2016
hsa-miR-21 MCF-7 PTEN PI3K-Akt signaling pathway MiR-21 regulates autophagy and apoptosis by suppression phosphatase and tensin homolog (PTEN) through targeting PI3K-Akt signaling pathway.
 Yu et al., 2016
hsa-miR-340 MCF-7, MDA-MB-231 Down ROCK1 Wnt signaling pathway MicroRNA-340 suppresses the migration, invasion, and metastasis of breast cancer cells by inhibiting Wnt pathway.
 Mohammadi-Yeganeh et al., 2016
hsa-miR-378 MCF-7, MDA-MB-231 RUNX1 PPAR signaling pathway Ectopic expression of microRNA-378 down-regulates Runx1 and inhibits migration and invasion in breast cancer.
 Browne et al., 2016
hsa-miR-148a MCF-7, MDA-MB-231 Down WNT1 Wnt signaling pathway MicroRNA-148a inhibits the migration and invasion of breast cancer cells by down-regulating WNT-1 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
hsa-miR-155 MCF-7, SK-BR-3 Up SOCS6 Jak-STAT signaling pathway MicroRNA-155 promotes TAM resistance in breast cancer by regulating SOCS6-STAT3 signaling pathway.
 Shen et al., 2015
hsa-miR-34a MCF-7, MDA-MB-231, MDA-MB-453 Down TPD52 TPD52 pathway MicroRNA-34a suppresses breast cancer progression and metastasis via inhibiting TPD52.
 Li et al., 2016
hsa-miR-27a MCF-7, MDA-MB-231, MCF-10A Up BAK BAK-SMAC/DIABLO-XIAP pathway Knockdown of miR-27a enhances the sensitivity of breast cancer cells to cisplatin treatment through BAK-SMAC/DIABLO-XIAP pathway.
 Zhou et al., 2016
hsa-miR-204 Breast Down SAM68 Wnt signaling pathway MicroRNA-204 suppresses the self-renewal of breast cancer cells by inhibiting Sam68 through regulating the Wnt signaling pathway.
Wang et al., 2015
hsa-miR-320a Breast Down RAB11A PI3K-Akt signaling pathway MicroRNA-320a functions as a tumor suppressor in breast cancer by targeting Rab11a through activation of the Akt signaling pathway.
 Wang et al., 2015
hsa-miR-181b Breast Up BIM miR-181b/Bim pathway MicroRNA-181b induces chemoresistance by regulating the expression of Bim in breast cancer.
 Zheng et al., 2016
hsa-miR-100 Breast Down FZD8 Wnt signaling pathway MicroRNA-100 inhibits the migration and invasion of breast cancer cells by down-regulating FZD-8 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
hsa-miR-7 MDA-MB-231 RAF 1 Raf signaling pathway Decreased expression of miR-7 by lapatinib is associated with the activation of Raf-1 signaling pathway in triple-negative breast cancer.
 Hsiao et al., 2015
hsa-miR-22 MCF-7, MDA-MB-231, MCF-10A Up TIP60 EMT pathway Blocking endogenous miR-22 enhances TIP60 levels, which in turn suppresses the migration and invasion capacity of metastatic breast cancer.
 Pandey et al., 2015
hsa-miR-1 MCF-7, MDA-MB-231, SK-BR-3 Down FRIZZLED 7 Wnt signaling pathway MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the Frizzled 7 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
hsa-miR-1 MCF-7, MDA-MB-231, SK-BR-3 Down TNKS2 Wnt signaling pathway MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the TNKS2 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
hsa-miR-200b Breast Down NF KAPPA B NF-Kappa B signaling pathway MicroRNA-200b inhibits breast cancer cell growth and migration, and NF-Kappa B activation in breast cancer.
 Wu et al., 2016
hsa-miR-199a Breast Down PAK4 ERK pathway MicroRNA-199a inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
hsa-miR-199b Breast Down PAK4 ERK pathway MicroRNA-199b inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
hsa-miR-506 Breast Down IQGAP1 ERK pathway MicroRNA-506 functions as a tumor suppressor by directly inhibiting IQGAP1 expression in breast cancer cells.
 Sun et al., 2015
hsa-miR-497 HUVEC VEGFR2 PI3K-Akt signaling pathway MicroRNA-497 suppresses tumor angiogenesis and growth through down-regulating VEGFR2 expression in breast cancer.
 Tu et al., 2015
hsa-miR-204 Breast Down JAK2 Jak-STAT signaling pathway MicroRNA-204 suppresses JAK2 expression, which further inhibits the activation of STAT3, BCl-2 and survivin in breast cancer.
 Wang et al., 2015
hsa-miR-451a MCF-7 Down MIF MIF signaling pathway Upregulation of miR-451a suppresses MIF expression and inhibits cell proliferation, colony formation, and invasion of breast cancer cells.
 Liu et al., 2015
hsa-miR-146a MCF-7 CXCR4 NF-Kappa B signaling pathway Down-regulation of microRNA-146a is associated with increased expression of CXCR4, TRAF6 and EGFR which further activates NF-Kappa B signaling pathway and enhances the proliferation, migration, invasion and anti-apoptotic activity.
 Zheng et al., 2015
hsa-miR-200a MDA-MB-231 EPHA2 Cadherin signaling pathway MicroRNA-200a suppresses migration of triple-negative breast cancer cells via direct inhibition of the EPHA2 oncogene.
 Tsouko et al., 2015
hsa-miR-200b MCF-7, MDA-MB-231, MDA-MB-157 RhoGDI pathway MicroRNA-200b inhibits the RhoGDI pathway, which leads to non-canonical suppression of epithelial-to-mesenchymal transition in triple-negative breast cancer.
 Rhodes et al., 2015
hsa-miR-200b MCF-7, MDA-MB-231, MDA-MB-157 RhoGDI pathway MicroRNA-200b inhibits the RhoGDI pathway, which leads to non-canonical suppression of epithelial-to-mesenchymal transition in triple-negative breast cancer.
 Rhodes et al., 2015
hsa-miR-144 MCF-7,SK-BR-3 RUNX1 Runx1 signaling Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.
 Vivacqua et al., 2015
hsa-miR-125a MCF-7, MCF-10A, MCF-12A, MDA-MB-231 Up LIFR Hippo signaling pathway MicroRNA-125a influences breast cancer stem cells by regulating Hippo signaling through targeting LIFR.
 Nandy et al., 2015
hsa-miR-9 MDA-MB-231 Up NOTCH1 Notch signaling pathway MicroRNA-9 elicits a suppressor-like activity in metastatic breast cancer cells by targeting Notch1.
 Mohammadi-Yeganeh et al., 2015
hsa-miR-494 MCF-7, MDA-MB-231 Down CXCR4 Wnt signaling pathway MicroRNA-494 inhibits the progression of breast cancer via the Wnt signaling pathway through targeting CXCR4.
 Song et al., 2015
hsa-miR-125b MCF-7 Down MCL1 Mitochondria-caspase-3 pathway Combined effect of miR-125b and doxorubicin causes the loss of mitochondrial membrane potential and mitochondria outer membrane permeability.
 Xie et al., 2015
hsa-miR-34a MCF-7 Down NOTCH1 Notch signaling pathway MicroRNA-34a suppresses breast cancer stemness and enhances the chemosensitivity to paclitaxel by targeting the Notch1 pathway.
 Kang et al., 2015
hsa-miR-21 4T1 Up PTEN PI3K-Akt signaling pathway MicroRNA-21 functions as a fine tuner in the regulation of PI3K-Akt signaling pathway in the expansion of CCR6(+) Tregs in tumor sites.
 Hu et al., 2015
hsa-miR-30c-2 MCF-7, MDA-MB-231, MCF-10A TRADD NF-Kappa B signaling pathway MicroRNA-30c-2 down-regulates NF-Kappa B signaling and cell cycle progression in breast cancer through inhibition of TRADD expression.
 Shukla et al., 2015
hsa-miR-542 MCF-7, SK-BR-3 PI3K-Akt signaling pathway Decreased expression of miRNA-542 is associated with trastuzumab resistance in breast cancer through regulating the PI3K-Akt signaling pathway.
 Ma et al., 2015
hsa-miR-26b MCF-7 Down REL A NF-Kappa B signaling pathway MicroRNA-26b plays an important role in wound healing and tumor-induced endothelial cell tube formation by down-regulating NF-Kappa B expression.
 Anbalagan et al., 2014
hsa-miR-562 MCF-7 Down NF KAPPA B NF-Kappa B signaling pathway MicroRNA-562 regulates wound healing and tumor-induced endothelial cell tube formation by inhibiting NF-Kappa B expression.
 Anbalagan et al., 2014
hsa-miR-335 MCF-7 Down MET c-MET signaling pathway MicroRNA-335 inhibits breast cancer cell migration by down-regulating the HGF/c-Met pathway.
 Gao et al., 2015
hsa-miR-142 MCF-7, MDA-MB-231 Up APC Wnt signaling pathway MicroRNA-142 regulates human breast cancer stem cell properties through activation of the Wnt signaling pathway.
 Isobe et al., 2014
hsa-miR-155 MCF-7 Up MAPK signaling pathway Upregulation of microRNA-155 enhances tumorigenesis through modulating mitogen activated protein kinase signaling pathway.
 Martin et al., 2014
hsa-miR-99a MCF-7, MDA-MB-231 Down MTOR mTOR pathway MicroRNA-99a inhibits the breast cancer malignant cancer stem cell phenotype by suppressing the mTOR signaling pathway.
 Yang et al., 2014
hsa-miR-378a HeLa Up AURORA B MAPK signaling pathway Overexpression of hsa-miR-378a activates MAPK signaling pathway and is associated with downregulation of Aurora B kinase. Excess miR-378a level is associated with the most aggressive, poorly differentiated forms of breast cancer.
 Winsel et al., 2014


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024