| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
|---|---|---|---|---|---|---|
| Acute lymphoblastic leukemia | hsa-miR-9 | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK6 | CDK6 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the CDK6-RB1 oncogenic pathway in acute lymphoblastic leukemia. | Rodriguez-Otero et al., 2011 |
| Acute lymphoblastic leukemia | hsa-miR-124a | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK6 | Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells. | Agirre et al., 2009 |
| Gastric cancer | hsa-miR-20a | BGC-823, HGC-27 | Up | FBXO31 | FBXO31 promotes G1 phase cell cycle arrest and causes the growth inhibitory role of gastric cancer. The upregulation of miR-20a is associated with suppression of FBXO31 in gastric cancer tissues. | Zhang et al., 2014 |
| Gastric cancer | hsa-miR-17 | BGC-823, HGC-27 | Up | FBXO31 | MicroRNA-17 down-regulates the expression of FBXO31. FBXO31 causes G1 phase cell cycle arrest and induces the growth inhibitory role of gastric cancer. | Zhang et al., 2014 |
| Hepatocellular carcinoma | hsa-miR-212 | Stomach | Down | RBP2 | Upregulation of hsa-miR-212 down-regulates the expression of RBP2 and suppresses cell proliferation in hepatocellular carcinoma. | Liang et al., 2013 |
| Cervical cancer | hsa-miR-195 | HeLa, SiHa | Down | CYCLIN D1 | MiR-195 suppresses human cervical cancer cells proliferation by directly inhibiting cyclin D1 expression. | Li et al., 2016 |
| Nasopharyngeal carcinoma | hsa-miR-539 | Nasopharynx | Down | CDK4 | MicroRNA-539 promotes the progression of nasopharyngeal carcinoma by down-regulating CDK4 expression. | Lv et al., 2015 |