Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
---|---|---|---|---|---|---|
Acute lymphoblastic leukemia | hsa-miR-9 | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK pathway | CDK6 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the CDK6-RB1 oncogenic pathway in acute lymphoblastic leukemia. | Rodriguez-Otero et al., 2011 |
Acute lymphoblastic leukemia | hsa-miR-124a | TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat | Down | CDK pathway | Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells. | Agirre et al., 2009 |