Targeted Gene Name:

CDK6

microRNA Score: 0.0086

Pathway Score: 0.0164

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Pathway More Details References
Acute lymphoblastic leukemia hsa-miR-9 TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat Down CDK pathway CDK6 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the CDK6-RB1 oncogenic pathway in acute lymphoblastic leukemia.
Rodriguez-Otero et al., 2011
Acute lymphoblastic leukemia hsa-miR-124a TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat Down CDK pathway Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells.
Agirre et al., 2009