| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Breast cancer | hsa-miR-146a | MCF-7 | NF-Kappa B signaling pathway | Down-regulation of microRNA-146a is associated with increased expression of CXCR4, TRAF6 and EGFR which further activates NF-Kappa B signaling pathway and enhances the proliferation, migration, invasion and anti-apoptotic activity. | Zheng et al., 2015 | |
| Breast cancer | hsa-miR-494 | MCF-7, MDA-MB-231 | Down | Wnt signaling pathway | MicroRNA-494 inhibits the progression of breast cancer via the Wnt signaling pathway through targeting CXCR4. | Song et al., 2015 |
| Prostate cancer | hsa-miR-494 | LNCaP, DU145, PC-3 | Down | miR-494-3p/CXCR4 pathway | MicroRNA-494 inhibits the proliferation, invasion and migration of prostate cancer cells through suppressing CXCR4 expression. | Shen et al., 2014 |
| Nasopharyngeal carcinoma | hsa-miR-9 | NP69 | Down | p38 MAPK signaling pathway | MicroRNA-9 acts as a tumor-suppressive microRNA by down-regulating CXCR4 expression in nasopharyngeal carcinoma. | Lu et al., 2014 |
| Oral squamous cell carcinoma | hsa-miR-9 | SCC-9, Tca8113 | Down | Wnt signaling pathway | MicroRNA-9 suppresses oral squamous cell carcinoma cell proliferation by down-regulating CXCR4 expression through the Wnt signaling pathway. | Yu et al., 2014 |