mirWay : Search Results

Disease Name:

Cervical Cancer

microRNA Score: 0.1034

Gene Score: 0.0732

Pathway Score: 0.1967

Micro RNA	Tissue/ Cell line	MicroRNA regulation	Targeted Member	Pathway	More Details	References
hsa-miR-744	HeLa, C-4-1, Ca Ski, SiHa	Up	BCL 2	Apoptosis pathway	MicroRNA-744 suppresses the expression of Bcl-2, which leads to the inactivation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorating cervical cancer growth and progression.	Chen et al., 2016
hsa-miR-429	C-33 A, HeLa	Down	IKK BETA	NF-Kappa B signaling pathway	MicroRNA-429 acts as a tumor suppressor in cervical carcinogenesisis through regulating the NF-Kappa B signaling pathway by down-regulating IKK-beta expression.	Fan et al., 2016
hsa-miR-21	HeLa, SiHa	Up		PI3K-Akt signaling pathway	MicroRNA-21 confers reduced autophagy in cervical cancer cells through the PI3K-Akt signaling pathway.	Song et al., 2016
hsa-miR-181a	End1/E6E7	Up		PI3K-Akt signaling pathway	MicroRNA-181a functions as an oncogene in cervical cancer. Reduced expression of miR-181a is associated with enhanced expression of PTEN and decreased phosphorylation of Akt and FOXO1.	Xu et al., 2016
hsa-miR-376c	HaCaT	Down	BMI1	BMI1 pathway	Over-expression of miR-376c inhibits cell proliferation, blocks G1/S checkpoint of cell cycle and represses cell invasion by targeting BMI1.	Deng et al., 2016
hsa-miR-195	HaCaT	Down	SMAD3	miR-195/Smad3 pathway	MicroRNA-195 inhibits migration and invasion of cervical cancer by targeting Smad3 expression.	Zhou et al., 2016
hsa-miR-130a	HeLa, Ca Ski		PTEN	NF-Kappa B signaling pathway	Overexpression of microRNA-130a regulates cervical cancer cell growth by inhibiting phosphatase and tensin homolog expression.	Feng et al., 2016
hsa-miR-125a	HeLa, Ca Ski	Down	ABL2	miR-125a-5p/ABL2 pathway	MicroRNA-125a regulates proliferation and migration of human cervical carcinoma by down-regulating ABL2 expression.	Qin et al., 2016
hsa-miR-195	HeLa, SiHa	Down	CYCLIN D1	CDK pathway	MiR-195 suppresses human cervical cancer cells proliferation by directly inhibiting cyclin D1 expression.	Li et al., 2016
hsa-miR-221	HeLa, SiHa	Up	PTEN	PI3K-Akt signaling pathway	MicroRNA-221 decreases the sensitivity of cervical cancer cells to gefitinib via the PI3K-Akt signaling pathway.	Du et al., 2016
hsa-miR-634		Down	MTOR	mTOR pathway	MicroRNA-634 promotes apoptosis and reduces cell proliferation in cervical cancer cells by inhibiting mTOR signaling pathway.	Cong et al., 2016
hsa-miR-491	HeLa, SiHa, MS751	Down	HTERT	PI3K-Akt signaling pathway	MicroRNA-491 inhibits cervical cancer cell growth through PI3K-Akt signaling pathway by down-regulating human telomerase reverse transcriptase (hTERT) expression.	Zhou et al., 2016
hsa-miR-21	HeLa, Ca Ski	Up	PTEN	PTEN pathway	MicroRNA-21 induces proliferation, migration and invasion in cervical cancer cells through targeting the PTEN expression.	Xu et al., 2015
hsa-miR-494	HeLa, Ca Ski, SiHa	Up	PTEN	PI3K-Akt signaling pathway	MicroRNA-494 enhances proliferation of cervical cancer through targeting PTEN expression.	Yang et al., 2015
hsa-miR-107	HeLa, SiHa	Down	MCL1	ATR/Chk1 pathway	MicroRNA-107 inhibits cervical cancer invasion through activating ATR/Chk1 pathway.	Zhou et al., 2014
hsa-miR-124	C-33 A, HeLa		AMOTL	Vasculogenic mimicry pathway	MicroRNA-124 inhibits vasculogenic mimicry, migration and invasion in cervical cancer by down-regulating the expression of AmotL1.	Wan et al., 2014
hsa-miR-31	HaCaT	Up	ARID1A	ARID1A pathway	MicroRNA-31 acts as an oncomir in cervical cancer through down-regulating ARID1A expression.	Wang et al., 2014
hsa-miR-99a	HeLa	Down	MTOR	mTOR pathway	Increased expression of miR-99a suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.	Wang et al., 2014
hsa-miR-99b	HeLa	Down	MTOR	mTOR pathway	Increased expression of miR-99b suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.	Wang et al., 2014
hsa-miR-135a	HeLa, Ca Ski, SiHa	Up	SIAH1	Beta-catenin pathway	MicroRNA-135a promotes cervical cancer cell transformation via regulating miR-135a/SIAH1/beta-catenin signaling pathway.	Leung et al., 2014
hsa-miR-451	HeLa, HUVEC, RKO	Down	IL6R	IL6R pathway	MicroRNA-451 function as a tumor suppressor by down-regulating the IL6R pathway.	Liu et al., 2014
hsa-miR-196a	HeLa, Ca Ski, SiHa	Up	FOXO1	PI3K-Akt signaling pathway	MicroRNA-196a enhances cervical cancer proliferation through targeting FOXO1, the key effector of the PI3K/Akt signaling pathway.	Hou et al., 2014
hsa-miR-196a	HeLa, Ca Ski, SiHa	Up	P27KIP1	PI3K-Akt signaling pathway	MicroRNA-196a enhances cervical cancer proliferation through targeting p27Kip1, the key effector of the PI3K/Akt signaling pathway.	Hou et al., 2014
hsa-miR-34a	HeLa, Ca Ski, SiHa	Down	NOTCH1	Notch signaling pathway	MicroRNA-34a suppresses invasiveness in cervical cancer through targeting the Notch pathway.	Pang et al., 2010