Disease Name:

Diffuse Large B-Cell Lymphoma

microRNA Score: 0.0388

Gene Score: 0.0274

Pathway Score: 0.0738

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up FOXO1 FoxO signaling pathway miR-21 plays an important oncogenic role by down regulating the expression of FOXO1 and modulating the FOXO1 pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PTEN PI3K-Akt signaling pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the PI3K-Akt signaling pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PTEN mTOR pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the mTOR pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
hsa-miR-124 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B PI3K-Akt signaling pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the PI3K-Akt signaling pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
hsa-miR-124 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B mTOR pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the mTOR pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
hsa-miR-124 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B MCL1 pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the MCL1 pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
hsa-miR-155 Ly1, Ly3, Ly10, Ly18, Ly19 Up SMAD5 TGF-beta signaling pathway Overexpression of hsa-miR-155 downregulates the expression of SMAD5, establishing a link between this miRNA, the TGF-beta signaling pathway, and lymphomagenesis.
 Rai et al., 2010
hsa-miR-21 CRL2631 Up PTEN PI3K-Akt signaling pathway hsa-miR-21 regulates the PI3K-Akt signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen.
 Bai et al., 2013
hsa-miR-155 CRL2631 Up PIK3R1 PI3K-Akt signaling pathway Overexpression of miR-155 activates PI3K-Akt signaling pathway through regulating PIK3R1 in in diffuse large B-cell lymphoma.
 Huang et al., 2012


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024