Pathway Name:

ERK pathway

microRNA Score: 0.0862

Gene Score: 0.061

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
B-cell non-Hodgkin lymphoma hsa-miR-28 Germinal Center B cells Down BAG1 hsa-miR-28 targets BCL2-associated athanogene (BAG1) involved in proliferation and apoptosis. BAG1 is an activator of the ERK pathway.
 Schneider et al., 2014
Hodgkin lymphoma hsa-miR-96 KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 hsa-miR-96 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Hodgkin lymphoma hsa-miR-182 KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 hsa-miR-182 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Hodgkin lymphoma hsa-miR-183 KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 hsa-miR-183 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Alzheimer's disease hsa-miR-34a SH-SY5Y Down MicroRNA-34a and its regulator TAp73 play an important role in tight regulation of the neuronal cell cycle via their ability to reduce cyclin D1. This balance is significantly altered when neurons encounter insults like A-beta-42, which aberrantly activates MEK-ERK signaling.
 Modi et al., 2015
Hepatitis C virus infection hsa-miR-27a Monocyte Up SPROUTY2 MicroRNA-27a regulates ERK phosphorylation by suppressing the expression of ERK inhibitor sprouty2 in monocytes.
 Saha et al., 2015
Hepatocellular carcinoma hsa-miR-133a Hepatocyte Down ERK MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth.
 Zhang et al., 2015
Non-small cell lung cancer hsa-miR-194 Lung Down HNUDC Over-expression of miR-194 suppresses the expression of Mpl/ERK pathway proteins, and inhibits the mitosis and proliferation of non-small cell lung cancer cells.
 Zhou et al., 2016
Small cell lung cancer hsa-miR-134 H69 Up WWOX MicroRNA-134 regulates cell proliferation and inhibits apoptosis through the activation of ERK1/2 pathway.
 Chen et al., 2015
Non-small cell lung cancer hsa-miR-3127 Lung Down ABL1 MicroRNA-3127 expression levels are associated with dasatinib sensitivity in non-small cell lung cancer through the c-Abl/Ras/ERK pathway.
Sun et al., 2014
Lung cancer hsa-miR-203 A-549, H1975, HCC827 SRC MicroRNA-203 inhibits the proliferation and migration and enhances the apoptosis of lung cancer cells by down-regulating the expression of SRC.
 Wang et al., 2014
Breast cancer hsa-miR-302 Breast Down MEKK1 MicroRNA-302 sensitizes breast cancer cells to adriamycin through targeting P-glycoprotein by inhibiting MEKK1 of ERK pathway.
 Zhao et al., 2016
Breast cancer hsa-miR-199a Breast Down PAK4 MicroRNA-199a inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Breast cancer hsa-miR-199b Breast Down PAK4 MicroRNA-199b inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Breast cancer hsa-miR-506 Breast Down IQGAP1 MicroRNA-506 functions as a tumor suppressor by directly inhibiting IQGAP1 expression in breast cancer cells.
 Sun et al., 2015
Hepatocellular carcinoma hsa-miR-133a Hepatocyte Down IGF 1R hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-9 Hepatocyte TAZ Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through ERK pathway.
 Higashi et al., 2015
Ovarian cancer hsa-miR-7 Ovary Down EGFR MicroRNA-7 suppresses tumor metastasis via ERK1/2 pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.
 Zhou et al., 2014
Follicular thyroid carcinoma hsa-miR-17 Thyroid gland PTK6 MicroRNA-17 suppresses the S1P-induced cell migration in follicular thyroid carcinoma through the ERK pathway.
 Zhao et al., 2015
Myocarditis hsa-miR-126 HeLa Up SPRED1 MicroRNA-126 activates ERK pathway through targeting SPRED1 and enhances CVB3 replication.
 Ye et al., 2013


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024