| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hodgkin lymphoma | hsa-miR-96 | KM-H2, L-428, L-1236, SUP-HD1 | Up | ERK pathway | hsa-miR-96 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| Hodgkin lymphoma | hsa-miR-182 | KM-H2, L-428, L-1236, SUP-HD1 | Up | ERK pathway | hsa-miR-182 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| Hodgkin lymphoma | hsa-miR-183 | KM-H2, L-428, L-1236, SUP-HD1 | Up | ERK pathway | hsa-miR-183 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| Diffuse Large B-cell lymphoma | hsa-miR-21 | OCI-Ly1, OCI-Ly18, SU-DHL-7 | Up | FoxO signaling pathway | miR-21 plays an important oncogenic role by down regulating the expression of FOXO1 and modulating the FOXO1 pathway in Diffuse Large B-cell lymphoma. | Go et al., 2015 |
| Anaplastic large cell lymphoma | hsa-miR-135b | Karpas-299, SU-DHL-1, SUP-M2 | Up | Jak-STAT signaling pathway | hsa-miR-135b downregulates FOXO1 in anaplastic large cell lymphoma pathogenesis. miR-135b acts as a downstream mediator of Jak-STAT signaling pathway. | Matsuyama et al., 2011 |
| Cervical cancer | hsa-miR-196a | HeLa, Ca Ski, SiHa | Up | PI3K-Akt signaling pathway | MicroRNA-196a enhances cervical cancer proliferation through targeting FOXO1, the key effector of the PI3K/Akt signaling pathway. | Hou et al., 2014 |
| Laryngeal squamous cell carcinoma | hsa-miR-132 | HEp-2, AMC-HN-8 | Up | PI3K-Akt signaling pathway | MicroRNA-132 functions as an oncogene in laryngeal squamous cell carcinoma by regulating the PI3K-Akt signaling pathway. | Lian et al., 2016 |
| Papillary thyroid carcinoma | hsa-miR-96 | TPC-1, K1 | Up | PI3K-Akt signaling pathway | MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway. | Song et al., 2015 |