Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
---|---|---|---|---|---|---|
Parkinson's disease | hsa-miR-7 | SH-SY5Y | Up | REL A | MicroRNA-7 increases Glut3 expression, promotes glycolysis, and subsequently inhibits MPP(+)-induced cell death by targeting RelA. | Chaudhuri et al., 2015 |
Hepatocellular carcinoma | hsa-miR-34a | Hep-G2, Huh-7 | Down | LDHA | In hepatocellular cancer cells, upregulation of miR-34a suppresses the expression of lactate dehydrogenase A (LDHA), which is a key enzyme in the glycolysis signaling pathway. | Li et al., 2016 |
Hepatocellular carcinoma | hsa-miR-122 | PLC/PRF/5 | - | PDK4 | miR-122 inhibits hepatocellular cancer stem cells phenotypes by regulating glycolysis via down-reguating PDK4. | Song et al., 2015 |
Ovarian cancer | hsa-miR-203 | IOSE-80, IOSE-144, OVCA429, OVCA433 | Up | PDHB | MicroRNA-203 functions as an ocogene in ovarian cancer by inducing glycolysis. | Xiaohong et al., 2016 |