hsa-miR-199a |
Huh-7.5.1 |
Up |
|
PI3K-Akt signaling pathway |
MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway. |
Wang et al., 2015 |
hsa-miR-199a |
Huh-7.5.1 |
Up |
|
RAS signaling pathway |
MicroRNA-199a promotes HCV replication by regulating Ras/ERK pathway. |
Wang et al., 2015 |
hsa-miR-199a |
Huh-7.5.1 |
Up |
|
Wnt signaling pathway |
MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway. |
Wang et al., 2015 |
hsa-miR-185 |
Hep-G2 |
|
SREBP2 |
SREBP pathway |
Upregulation of microRNA-185 suppresses the expression of SREBP2 by HCV core protein. |
Li et al., 2015 |
hsa-miR-146a |
Peripheral blood monocyte |
Up |
|
Toll-like receptor signaling pathway |
MicroRNA-146a expression is abnormally enhanced in peripheral blood monocytes of HCV-infected patients. The Toll-like receptor signaling pathway takes part in the upregulation of miR-146a in monocytes stimulated with HCV core protein. |
Zhang et al., 2015 |
hsa-miR-122 |
Hep-G2 |
|
HCBP6 |
SREBP pathway |
Over-expression of microRNA-122 suppresses the expression of HCBP6 (hepatitis C virus core-binding protein 6) which modulates TG (Triglyceride) Homeostasis in Hepatocytes through the SREBP pathway. |
Gao et al., 2015 |
hsa-miR-27a |
Monocyte |
Up |
SPROUTY2 |
ERK pathway |
MicroRNA-27a regulates ERK phosphorylation by suppressing the expression of ERK inhibitor sprouty2 in monocytes. |
Saha et al., 2015 |
hsa-miR-373 |
Hepatocyte |
Up |
JAK1 |
IFN signaling pathway |
Upregulation of microRNA-373 impairs IFN signaling by down-regulating JAK1 molecules. |
Mukherjee et al., 2015 |
hsa-miR-373 |
Hepatocyte |
Up |
IRF9 |
IFN signaling pathway |
Upregulation of microRNA-373 impairs IFN signaling by down-regulating IRF9 molecules. |
Mukherjee et al., 2015 |
hsa-miR-221 |
Huh-7.5.1 |
Up |
SOCS1 |
Jak-STAT signaling pathway |
MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS1. |
Xu et al., 2014 |
hsa-miR-221 |
Huh-7.5.1 |
Up |
SOCS3 |
Jak-STAT signaling pathway |
MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS3. |
Xu et al., 2014 |
hsa-miR-449a |
Hep-G2 |
Down |
IL 6 |
IL-6-mediated signaling pathway |
MicroRNA-449a regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating IL-6R. |
Sarma et al., 2014 |
hsa-miR-107 |
Hep-G2 |
Down |
JAK1 |
IL-6-mediated signaling pathway |
MicroRNA-107 regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating JAK1. |
Sarma et al., 2014 |
hsa-miR-200c |
Hepatocyte |
Up |
FAP1 |
Src pathway |
Upregulation of miR-200c down-regulates the expression of FAP1, a critical regulator of Src pathway that play an important role in the development of fibrosis and production of fibrogenic growth factors. |
Ramachandran et al., 2014 |
hsa-miR-21 |
HEK293 |
Up |
MYD88 |
IFN signaling pathway |
MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting MyD88. |
Chen et al., 2014 |
hsa-miR-21 |
HEK293 |
Up |
IRAK1 |
IFN signaling pathway |
MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting IRAK1. |
Chen et al., 2014 |
hsa-miR-449a |
Hep-G2 |
Down |
NOTCH1 |
Notch signaling pathway |
MicroRNA-449a plays an important role in regulating the expression of YKL40 through down-regulating NOTCH1 which is the components of the NOTCH signaling pathway. |
Sarma et al., 2012 |
hsa-miR-155 |
Hepatocyte |
Up |
APC |
Wnt signaling pathway |
Over-expression of microRNA-155 promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling pathway. |
Zhang et al., 2012 |
hsa-miR-146a |
Peripheral blood mononuclear cells |
Down |
|
Toll-like receptor signaling pathway |
HCV infection suppresses the induction of miR-146a by modulating Toll-like receptor signaling pathway. |
El-Ekiaby et al., 2012 |
hsa-miR-155 |
Peripheral blood mononuclear cells |
Down |
|
Toll-like receptor signaling pathway |
HCV infection suppresses the induction of miR-155 by modulating Toll-like receptor signaling pathway. |
El-Ekiaby et al., 2012 |
hsa-miR-491 |
Huh-7 |
Down |
AKT |
PI3K-Akt signaling pathway |
MicroRNA-491 represses the phosphoinositol-3 (PI3) kinase/PI3K-Akt signaling pathway. |
Ishida et al., 2011 |
hsa-miR-21 |
Huh-7.5 |
Up |
SMAD7 |
TGF-beta signaling pathway |
MicroRNA-21 down-regulates the expression of SMAD7 and enhances TGF-beta signaling, leads to increase fibrogenesis. |
Marquez et al., 2010 |