Disease Name:

Hepatitis C Virus Infection

microRNA Score: 0.0905

Gene Score: 0.064

Pathway Score: 0.1721

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-199a Huh-7.5.1 Up PI3K-Akt signaling pathway MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway.
Wang et al., 2015
hsa-miR-199a Huh-7.5.1 Up RAS signaling pathway MicroRNA-199a promotes HCV replication by regulating Ras/ERK pathway.
Wang et al., 2015
hsa-miR-199a Huh-7.5.1 Up Wnt signaling pathway MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway.
Wang et al., 2015
hsa-miR-185 Hep-G2 SREBP2 SREBP pathway Upregulation of microRNA-185 suppresses the expression of SREBP2 by HCV core protein.
Li et al., 2015
hsa-miR-146a Peripheral blood monocyte Up Toll-like receptor signaling pathway MicroRNA-146a expression is abnormally enhanced in peripheral blood monocytes of HCV-infected patients. The Toll-like receptor signaling pathway takes part in the upregulation of miR-146a in monocytes stimulated with HCV core protein.
Zhang et al., 2015
hsa-miR-122 Hep-G2 HCBP6 SREBP pathway Over-expression of microRNA-122 suppresses the expression of HCBP6 (hepatitis C virus core-binding protein 6) which modulates TG (Triglyceride) Homeostasis in Hepatocytes through the SREBP pathway.
Gao et al., 2015
hsa-miR-27a Monocyte Up SPROUTY2 ERK pathway MicroRNA-27a regulates ERK phosphorylation by suppressing the expression of ERK inhibitor sprouty2 in monocytes.
Saha et al., 2015
hsa-miR-373 Hepatocyte Up JAK1 IFN signaling pathway Upregulation of microRNA-373 impairs IFN signaling by down-regulating JAK1 molecules.
Mukherjee et al., 2015
hsa-miR-373 Hepatocyte Up IRF9 IFN signaling pathway Upregulation of microRNA-373 impairs IFN signaling by down-regulating IRF9 molecules.
Mukherjee et al., 2015
hsa-miR-221 Huh-7.5.1 Up SOCS1 Jak-STAT signaling pathway MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS1.
Xu et al., 2014
hsa-miR-221 Huh-7.5.1 Up SOCS3 Jak-STAT signaling pathway MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS3.
Xu et al., 2014
hsa-miR-449a Hep-G2 Down IL 6 IL-6-mediated signaling pathway MicroRNA-449a regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating IL-6R.
Sarma et al., 2014
hsa-miR-107 Hep-G2 Down JAK1 IL-6-mediated signaling pathway MicroRNA-107 regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating JAK1.
Sarma et al., 2014
hsa-miR-200c Hepatocyte Up FAP1 Src pathway Upregulation of miR-200c down-regulates the expression of FAP1, a critical regulator of Src pathway that play an important role in the development of fibrosis and production of fibrogenic growth factors.
Ramachandran et al., 2014
hsa-miR-21 HEK293 Up MYD88 IFN signaling pathway MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting MyD88.
Chen et al., 2014
hsa-miR-21 HEK293 Up IRAK1 IFN signaling pathway MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting IRAK1.
Chen et al., 2014
hsa-miR-449a Hep-G2 Down NOTCH1 Notch signaling pathway MicroRNA-449a plays an important role in regulating the expression of YKL40 through down-regulating NOTCH1 which is the components of the NOTCH signaling pathway.
Sarma et al., 2012
hsa-miR-155 Hepatocyte Up APC Wnt signaling pathway Over-expression of microRNA-155 promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling pathway.
Zhang et al., 2012
hsa-miR-146a Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-146a by modulating Toll-like receptor signaling pathway.
El-Ekiaby et al., 2012
hsa-miR-155 Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-155 by modulating Toll-like receptor signaling pathway.
El-Ekiaby et al., 2012
hsa-miR-491 Huh-7 Down AKT PI3K-Akt signaling pathway MicroRNA-491 represses the phosphoinositol-3 (PI3) kinase/PI3K-Akt signaling pathway.
Ishida et al., 2011
hsa-miR-21 Huh-7.5 Up SMAD7 TGF-beta signaling pathway MicroRNA-21 down-regulates the expression of SMAD7 and enhances TGF-beta signaling, leads to increase fibrogenesis.
Marquez et al., 2010