Disease Name:

Hepatocellular Carcinoma

microRNA Score: 0.4741

Gene Score: 0.3354

Pathway Score: 0.9016

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-144 Hep-G2, SK-BR-3 Up RUNX1 Runx1 signaling Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.
 Vivacqua et al., 2015
hsa-miR-655 Hep-G2, Huh-7, MHCC97-H, MHCC97-L Down ADAM10 Beta-catenin pathway MiR-655 acts as a tumor suppressor by directly inhibiting ADAM10 and indirectly regulating beta-catenin pathway in the development of progression of hepatocellular carcinoma.
 Wu et al., 2016
hsa-miR-133a Hepatocyte Down AKT PI3K-Akt signaling pathway Upregulation of miR-133a suppresses the activation of AKT signal pathway, which contributes to inhibition of hepatocellular carcinoma (HCC) cell growth. MicroRNA-133a acts as a tumor suppressor and represses survival of HCC cells by down-regulating IGF-1R.
 Zhang et al., 2015
hsa-miR-133a Hepatocyte Down ERK ERK pathway MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth.
 Zhang et al., 2015
hsa-miR-212 Stomach Down RBP2 CDK pathway Upregulation of hsa-miR-212 down-regulates the expression of RBP2 and suppresses cell proliferation in hepatocellular carcinoma.
 Liang et al., 2013
hsa-miR-21 Hep-G2 Up HBP1 p53 signaling pathway MicroRNA-21 induces hepatocellular carcinoma progression through targeting Hbp1-p53-Srebp1c pathway.
 Wu et al., 2015
hsa-miR-28 Hepatocyte Down IGF1 PI3K-Akt signaling pathway Decreased expression of miR-28 is associated with tumor growth via PI3K-Akt signaling pathway by down-regulating IGF1 in hepatocellular carcinoma.
 Shi et al., 2015
hsa-miR-200b BEL-7402, SMMC-7221 Down RHOA RhoA pathway Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting RhoA.
 Wong et al., 2015
hsa-miR-200b BEL-7402, SMMC-7221 Down ROCK2 RhoA pathway Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting ROCK2.
 Wong et al., 2015
hsa-miR-155 BEL-7402, Hep-G2, SMMC-7721 Up ARID2 PI3K-Akt signaling pathway MicroRNA-155 enhances tumor growth in hepatocellular carcinoma by inhibiting ARID2-mediated Akt phosphorylation pathway.
 Zhang et al., 2016
hsa-miR-186 Hep-G2, SNU-398 YAP1 Hippo signaling pathway MicroRNA-186 suppresses hepatocellular carcinoma tumorigenesis through inhibiting the expression of YAP1.
 Ruan et al., 2016
hsa-miR-370 Hep-G2, SMMC-7721, MHCC97 Down PI3K-Akt signaling pathway MicroRNA-370 suppresses liver cancer cell proliferation by regulating PI3K-Akt signaling pathway.
 Sun et al., 2016
hsa-miR-452 Hep-G2, LM3, HEK293T Up SOX7 Wnt signaling pathway MicroRNA-452 regulates stem-like cells of hepatocellular carcinoma through Wnt signaling pathway by targeting Sox7 expression.
 Zheng et al., 2016
hsa-miR-122 HUVEC TGFBR1 TGF-beta signaling pathway Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1.
 Yin et al., 2016
hsa-miR-34a Hep-G2, Huh-7 Down LDHA Glycolysis pathway In hepatocellular cancer cells, upregulation of miR-34a suppresses the expression of lactate dehydrogenase A (LDHA), which is a key enzyme in the glycolysis signaling pathway.
 Li et al., 2016
hsa-miR-127 SMMC-7721, SNU-449, HEK293T Down BLVRB NF-Kappa B signaling pathway MicroRNA-127 represses NF-Kappa B activity by directly inhibiting biliverdin reductase B (BLVRB) in hepatocellular carcinoma cells.
 Huan et al., 2016
hsa-miR-192 HEK293T, Huh-7 Down SLC39A6 SNAIL pathway MicroRNA-192 inhibits the SNAIL pathway to reduce tumor metastasis in hepatocellular carcinoma cells.
 Lian et al., 2016
hsa-miR-125a Hep-G2, LM3 Down PI3K PI3K-Akt signaling pathway MicroRNA-125a directly targets PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
hsa-miR-125a Hep-G2, LM3 Down AKT PI3K-Akt signaling pathway MicroRNA-125a down-regulates the expression of PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
hsa-miR-125a Hep-G2, LM3 Down MTOR PI3K-Akt signaling pathway Over-expression of microRNA-125a inhibits the expression of mTOR. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
hsa-miR-30a Hep-G2, SMMC-7721, MHCC97 Down MTDH PI3K-Akt signaling pathway MicroRNA-30a acts as a tumor suppressor by directly suppressing metadherin (MTDH) in hepatocellular carcinoma.
 Li et al., 2016
hsa-miR-34a Hep-G2 Up BETA CATENIN Wnt signaling pathway Over-expression of miR-34a inhibits the expression of Wnt signaling pathway by down-regulating beta-catenin.
 Zhu et al., 2015
hsa-miR-122 PLC/PRF/5 - PDK4 Glycolysis pathway miR-122 inhibits hepatocellular cancer stem cells phenotypes by regulating glycolysis via down-reguating PDK4.
 Song et al., 2015
hsa-miR-16 SK-HEP-1 PI3K PI3K-Akt signaling pathway Upregulation of microRNA-16 suppresses PI3K expression and Akt phosphorylation. MicroRNA-16 overexpression inhibits the proliferation, invasion and metastasis of hepatocellular carcinoma cells, and these effects are associated with the PI3K-Akt signaling pathway.
 Wu et al., 2015
hsa-miR-424 Hepatocyte Down AKT3 E2F Signaling pathway Over-expression of miR-424 inhibits hepatocellular carcinoma cell proliferation by targeting AKT3.
 Yang et al., 2015
hsa-miR-424 Hepatocyte Down E2F3 E2F Signaling pathway Over-expression of miR-424 inhibits hepatocellular carcinoma cell proliferation by targeting E2F3.
 Yang et al., 2015
hsa-miR-338 Hepatocyte TAZ Hippo signaling pathway TAZ is involved in the growth of hepatocellular carcinoma cells. Upregulation of miR-338 suppresses the expression of TAZ.
 Liu et al., 2015
hsa-miR-21 Hepatocyte Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-21 reduces PTEN expression and sequential Akt activation. It suppresses autophagy through PI3K-Akt signaling pathway.
 He et al., 2015
hsa-miR-132 Hep-G2, SMMC-7721, Huh-7 Down PIK3R3 mTOR pathway Overexpression hsa-miR-132 inhibits PIK3R3 expression. miR-132 suppresses proliferation, invasion and migration of HCC through inactivating AKT/mTOR pathway
 Liu et al., 2015
hsa-miR-194 Hepatocyte Down TRIM23 NF-Kappa B signaling pathway hsa-miR-23 directly targeted TRIM23. TNF alpha-NF-Kappa B signaling switches off negative regulation by repressing HNF-1 alpha-mediated expression of hsa-miR-194.
 Bao et al., 2015
hsa-miR-9 Hepatocyte Up CDH1 PPAR signaling pathway hsa-miR-9 controls CDH1 expression through directly targeting CDH1 and indirectly through PPARA. hsa-miR -9 is the key regulator of HCC oncogenesis via PPAR signaling pathway.
 Drakaki et al., 2015
hsa-miR-9 Hepatocyte Up PPARA PPAR signaling pathway hsa-miR-9 controls CDH1 expression through directly targeting CDH1 and indirectly through PPARA. hsa-miR -9 is the key regulator of HCC oncogenesis via PPAR signaling pathway.
 Drakaki et al., 2015
hsa-miR-491 Hepatocyte Down GIT 1 NF-Kappa B signaling pathway Overexpression of hsa-miR-491 blocks the activation of GIT-1 mediated ERK which inactivate NF-Kappa B signaling pathway
 Yang et al., 2016
hsa-miR-208 Hep-G2, Hep-3B ARID2 TGF-beta signaling pathway Overexpression of hsa-miR-208 downregulates ARID2 expression.TGF-beta-1 activated miR-208 promotes HCC cell progression by targeting ARID2 via TGF-beta signaling pathway.
Yu et al., 2015
hsa-miR-28 Hepatocyte IGF1 PI3K-Akt signaling pathway hsa-miR-28 directly targets the expression of insulin-like growth factor 1. Downregulation of miR-28 is associated with tumor proliferation and migration through PI3K-Akt signaling pathway by targeting IGF1.
 Shi et al., 2015
hsa-miR-133a Hepatocyte Down IGF 1R PI3K-Akt signaling pathway hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
hsa-miR-133a Hepatocyte Down IGF 1R ERK pathway hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
hsa-miR-205 Hepatocyte Up USP7 p53 signaling pathway Overexpression of hsa-miR-205 represses the expression of USP7. Mir-205 modulates p53 signaling pathway and cell proliferation levels in hepatocellular carcinoma cell.
 Zhu et al., 2015
hsa-miR-9 Hepatocyte TAZ PI3K-Akt signaling pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through PI3K-Akt signaling pathway.
 Higashi et al., 2015
hsa-miR-9 Hepatocyte TAZ ERK pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through ERK pathway.
 Higashi et al., 2015
hsa-miR-9 Hepatocyte TAZ Beta-catenin pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through Beta-catenin pathway.
 Higashi et al., 2015
hsa-miR-26b Hepatocyte Down MCL1 MCL1 pathway hsa-miR-26b directly targets Mcl-1 mRNA which plays an important role in the sensitization effect of miR-26b on TRAIL-induced apoptosis in HCC. miR-26b/Mcl-1 pathway might act as a sensitizer for chemotherapy.
 Jiang et al., 2015
hsa-miR-20a Hepatocyte Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-20a downregulates PTEN expression. Mir-20a promotes HCC cell radioresistance by activating the PTEN/PI3K-Akt signaling pathway.
 Zhang et al., 2015
hsa-miR-26a Hepatocyte M CSF PI3K-Akt signaling pathway hsa-miR-26a downregulates M-CSF expression and inhibits macrophage recruitment via PI3K-Akt signaling pathway.
 Chai et al., 2015
hsa-miR-193b Hepatocyte Down MCL1 Caspase 3 pathway Mcl-1 is the direct target of hsa-miR-193b and overexpression of hsa-miR-193b increased cancer cell sensitivity via caspase dependent apoptosis pathway.
 Yin et al., 2015
hsa-miR-128 Hepatocyte Down PIK3R1 PI3K-Akt signaling pathway Overexpression of hsa-miR-128 suppress HCC cell proliferation by regulating PIK3R1 expression and PI3K-Akt signaling pathway.
 Huang et al., 2015
hsa-miR-429 Hepatocyte PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-429 directly targets PTEN expression. hsa-miR-429 promotes HCC cell migration and invasion through PI3K-Akt signaling pathway.
 Tang et al., 2015
hsa-miR-200b Hepatocyte Down RHOA RhoA pathway RhoA is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway.
 Wong et al., 2015
hsa-miR-200b Hepatocyte Down ROCK2 RhoA pathway ROCK2 is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway.
 Wong et al., 2015
hsa-miR-141 Hepatocyte Up KEAP1 Nrf2 signaling pathway Re-expression of hsa-miR-141 downregulates Keap1 expression, resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation and Nrf2-dependent antioxidant pathway reactivation in hepatocellular carcinoma cell.
 Shi et al., 2015
hsa-miR-3127 Hepatocyte Up PHLPP2 PI3K-Akt signaling pathway PHLPP1 and PHLPP2 are the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
hsa-miR-3127 Hepatocyte Up INPP4A PI3K-Akt signaling pathway INPP4A is the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
hsa-miR-3127 Hepatocyte Up INPP5J PI3K-Akt signaling pathway INPP5J is the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
hsa-miR-432 Hepatocyte Down LRP6 Wnt signaling pathway Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of LRP6 of the Wnt signaling pathway.
 Jiang et al., 2015
hsa-miR-432 Hepatocyte Down TRIM29 Wnt signaling pathway Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of TRIM29 of the Wnt signaling pathway.
 Jiang et al., 2015
hsa-miR-432 Hepatocyte Down PYGO2 Wnt signaling pathway Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of Pygo2 of the Wnt signaling pathway.
 Jiang et al., 2015
hsa-miR-216b Hepatocyte Down IGF2BP2 IGF signaling pathway Overexpression of hsa-miR-216b suppresses HCC cell proliferation and invasion by targeting IGF2BP2 through HBx-miR-216b-IGF2BP2 signaling pathway.
 Liu et al., 2015
hsa-miR-96 Hepatocyte Up IGF 1R IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-182 Hepatocyte Up IGF 1R IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-96 Hepatocyte Up IGFBP 3 IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-182 Hepatocyte Up IGFBP 3 IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-96 Hepatocyte Up IGF-II IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-182 Hepatocyte Up IGF-II IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
hsa-miR-1236 Hepatocyte Down AFP PI3K-Akt signaling pathway Overexpression of hsa-miR-1236 downregulates the expression of AFP, thus suppressing PTEN ubiquitination to up-regulate the expression of PTEN and leading to inhibition of the PI3K-Akt signaling pathway.
 Gao et al., 2015
hsa-miR-153 Hepatocyte Up WWOX Wnt signaling pathway Overexpression of hsa-miR-153 downregulates WWOX, a tumor suppressor and inhibitor of Wnt signaling pathway in hepatocellular carcinoma.
 Hua et al., 2015
hsa-miR-34a Hepatocyte Down FOX M1 Myc pathway hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma.
 Xu et al., 2015
hsa-miR-34a Hepatocyte Down MYC Myc pathway hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma.
 Xu et al., 2015
hsa-miR-32 Hepatocyte Up PTEN PI3K-Akt signaling pathway hsa-miR-32 promotes hepatocellular carcinoma cell proliferation, migration and invasion via PI3K-Akt signaling pathway through targeting PTEN.
 Yan et al., 2015
hsa-miR-93 Hepatocyte Up PTEN PI3K-Akt signaling pathway hsa-miR-93 suppresses the expression of PTEN, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
hsa-miR-93 Hepatocyte Up CDKN1A PI3K-Akt signaling pathway hsa-miR-93 suppresses the expression of CDKN1A, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
hsa-miR-148b Hepatocyte Down WNT1 Wnt signaling pathway hsa-miR-148b suppresses the expression of Wnt-1. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
hsa-miR-148b Hepatocyte Down BETA CATENIN Wnt signaling pathway hsa-miR-148b suppresses the expression of beta-catenin. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
hsa-miR-148b Hepatocyte Down MYC Wnt signaling pathway hsa-miR-148b suppresses the expression of c-Myc. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
hsa-miR-511 Hepatocyte Down PIK3R3 mTOR pathway hsa-miR-511 inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma by directly targeting the AKT/mTOR pathway.
 Cao et al., 2015
hsa-miR-1246 Hepatocyte NFIB p53 signaling pathway p53 controls the expression of hsa-miR-1246 in hepatocellular carcinoma. hsa-miR-1246 directly targets nuclear factor I/B (NFIB). Overexpression of hsa-miR-1246 promotes cell proliferation, colony formation and apoptosis through modulating p53 signaling pathway in hepatocellular carcinoma.
 Zhang et al., 2015
hsa-miR-342 Hepatocyte IKK GAMMA NF-Kappa B signaling pathway hsa-miR-342 play an important role in hepatocellular carcinoma cell proliferation. hsa-miR-342 regulates NF-Kappa B signaling pathway via directly suppressing IKK-gamma.
 Zhou et al., 2015
hsa-miR-342 Hepatocyte TAB2 NF-Kappa B signaling pathway hsa-miR-342 play an important role in hepatocellular carcinoma cell proliferation. hsa-miR-342 regulates NF-Kappa B signaling pathway via directly suppressing TAB2.
 Zhou et al., 2015
hsa-miR-342 Hepatocyte TAB3 NF-Kappa B signaling pathway hsa-miR-342 play an important role in hepatocellular carcinoma cell proliferation. hsa-miR-342 regulates NF-Kappa B signaling pathway via directly suppressing TAB3.
 Zhou et al., 2015
hsa-miR-340 Hepatocyte Down NRF2 Nrf2 signaling pathway hsa-miR-340 is associated with development of cisplatin resistance in hepatocellular carcinoma by suppressing Nrf2-dependent antioxidant pathway.
 Shi et al., 2014
hsa-miR-338 Hepatocyte Down HIF 1 ALPHA HIF signaling pathway hsa-miR-338 suppresses HCC tumor growth and sensitizes hepatocellular carcinoma cells to sorafenib by targeting HIF-1 alpha.
 Xu et al., 2014
hsa-miR-610 Hepatocyte Down LRP6 Wnt signaling pathway Overexpression of hsa-miR-610 suppresses hepatocellular carcinoma cell proliferation and tumorigenicity. hsa-miR-610 directly targets LRP6 , which results in activation of WNT-beta catenin activity.
 Zeng et al., 2014
hsa-miR-610 Hepatocyte Down TBL1X Wnt signaling pathway hsa-miR-610 downregulates TBL1X , which results in activation of WNT-beta catenin activity.Overexpression of hsa-miR-610 suppresses hepatocellular carcinoma cell proliferation and tumorigenicity.
Zeng et al., 2014
hsa-miR-486 Hepatocyte Down PIK3R1 PI3K-Akt signaling pathway hsa-miR-486 inhibits hepatocellular carcinoma cell proliferation by downregulating PIK3R1 expression and suppressing PI3K-Akt signaling pathway activation.
 Huang et al., 2015
hsa-miR-362 Hepatocyte Up CYLD NF-Kappa B signaling pathway hsa-miR-362 acts through CYLD to activate the NF-Kappa B signaling pathway, which promotes hepatocellular carcinoma cell growth and metastasis.
 Ni et al., 2015
hsa-miR-149 Hepatocyte AKT mTOR pathway hsa-miR-149 acts as a tumor suppressive microRNA and play a vital role in suppressing hepatocellular carcinoma tumorigenesis by modulating by AKT/mTOR pathway.
Zhang et al., 2014
hsa-miR-29b LX-1, HSC-T6 Down PIK3R1 PI3K-Akt signaling pathway hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs).
 Wang et al., 2015
hsa-miR-29b LX-1, HSC-T6 Down AKT3 PI3K-Akt signaling pathway hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs).
 Wang et al., 2015
hsa-miR-105 Hepatocyte Down IRS1 PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of IRS1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
hsa-miR-105 Hepatocyte Down AKT PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of AKT1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
hsa-miR-105 Hepatocyte Down PDK1 PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of PDK1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
hsa-miR-10b Hepatocyte Up HOXD10 RhoC pathway hsa-miR-10b acts as tumor metastatic factorin hepatocellular carcinoma cell through the HOXD10/ RhoC/ uPAR/ MMPs pathway.
 Liao et al., 2014
hsa-miR-218 Hepatocyte Down HOXA10 PI3K-Akt signaling pathway Overexpression of miR-218 reduces cancer cell proliferation in hepatocellular carcinoma through PI3K-Akt signaling pathway with possible association of HoxA10.
 Xiao et al., 2014
hsa-miR-449 Hepatocyte SIRT1 SREBP pathway MicroRNA-449 inhibits SIRT1-SREBP signaling via downregulating expression of SIRT1 and re-programs lipogenesis and cholesterogenesis in hepatocellular carcinoma.
 Zhang et al., 2014
hsa-miR-222 Hepatocyte Up PI3K-Akt signaling pathway hsa-miR-222 affects cell proliferation, migration and invasion, and enhance the resistance of hepatocellular carcinoma cells to sorafenib via regulation of the PI3K-Akt signaling pathway.
 Liu et al., 2014
hsa-miR-122 Hepatocyte Up RHOA RhoA pathway Overexpression of hsa-miR-122 downregulates RhoA, suppressing the RhoA pathway, enhancing cell adhesion and cell junction, impairing cytoskeletal events, and decreasing cell motility in hepatocellular carcinoma.
 Wang et al., 2014
hsa-miR-137 Hepatocyte Down AKT mTOR pathway FoxD3-regulated miR-137 suppresses hepatocellular carcinoma cell growth and metastasis through inhibiting AKT2/mTOR pathway via targeting AKT2.
 Liu et al., 2014
hsa-miR-185 Hepatocyte Down DNMT1 PI3K-Akt signaling pathway hsa-miR-185 acts as a tumor suppressor microRNA that prevents hepatocellular carcinoma cell growth by downregulating DNMT1, leading to PTEN induction and Akt inhibition.
 Qadir et al., 2014
hsa-miR-26b Hepatocyte Down USP9X TGF-beta signaling pathway Overexpression of miR-26b downregulates the expression of USP9X, which in turn affects epithelial-mesenchymal transition of hepatocellular carcinoma cells through TGF-beta signaling pathway.
 Shen et al., 2014
hsa-miR-148a Hepatocyte SMAD2 TGF-beta signaling pathway Overexpression of miR-148a inhibits the expression of SMAD2 and cancer stem cell-like properties in hepatocellular carcinoma cells throughTGF-beta signaling pathway.
 Jiang et al., 2014
hsa-miR-612 Hepatocyte AKT Wnt signaling pathway hsa-miR-612 negatively regulates cancer stem cells of hepatocellular carcinoma through Wnt signaling pathway.
 Tang et al., 2014
hsa-miR-625 Hepatocyte Down IGF2BP1 PTEN pathway MicroRNA-625 acts as an antimetastatic miRNA and regulates HCC progression by modulating the IGF2BP1/PTEN pathway.
 Zhou et al., 2015
hsa-miR-363 Hepatocyte Down S1PR1 S1PR1 pathway MicroRNA-363 suppresses hepatocellular carcinoma cell proliferation by downregulating S1PR1 via miR-363/S1PR1 pathway.
 Zhou et al., 2014
hsa-miR-26b Hepatocyte TAK1 NF-Kappa B signaling pathway Overexpression of miR-26b inhibits NF-kappa B signaling pathway and thereby sensitized hepatocellular carcinoma cells to the doxorubicin-induced apoptosis by downregulating the expression of TAK1.
 Zhou et al., 2014
hsa-miR-26b Hepatocyte TAB3 NF-Kappa B signaling pathway Overexpression of miR-26b inhibits NF-kappa B signaling pathway and thereby sensitized hepatocellular carcinoma cells to the doxorubicin-induced apoptosis by downregulating the expression of TAB3.
 Zhou et al., 2014
hsa-miR-134 Hepatocyte Down ITGB1 ITGB1 pathway MicroRNA-134 significantly suppresses hepatocellular carcinoma cell invasion and metastasis by targeting integrin beta-1. miR-134 also suppresses the phosphorylation of focal adhesion kinase and the activation of RhoA downstream of the ITGB1 pathway, thereby inhibiting stress fiber formation and cell adhesion in hepatocellular carcinoma cells.
 Zha et al., 2014
hsa-miR-26a Hepatocyte Down HGF c-MET signaling pathway hsa-miR-26a inhibits tumor angiogenesis in hepatocellular carcinoma via HGF-cMet signaling pathway.
 Yang et al., 2014
hsa-miR-26a Hepatocyte PIK3C2 ALPHA PI3K-Akt signaling pathway MicroRNA-26a regulates angiogenesis of hepatocellular carcinoma through the PIK3C2-alpha/Akt/HIF-1-alpha/VEGFA pathway.
 Chai et al., 2014
hsa-miR-139 Hepatocyte Down TCF 4 Wnt signaling pathway Overexpression of miR-139 expression suppressess hepatocellular carcinoma cell proliferation and invasion via Wnt signaling pathway.
 Gu et al., 2014
hsa-miR-21 Hepatocyte Up MAP2K3 MAPK signaling pathway Overexpression of miR-21 post-transcriptionally inhibits MAP2K3 signaling in hepatocellular carcinoma cell development.
 Xu et al., 2013
hsa-miR-302b Hepatocyte Down EGFR EGFR signaling pathway MicroRNA-302b targets EGFR, and the cell cycle progression is arrested at the G0/G1-phase. At the same time, the expression of AKT2 is down-regulated, and CCND1 and CDK2 are reduced by miR-302b. Thus, overexpression of miR-302b inhibits the growth of hepatoma cells may due to targeting the EGFR/AKT2/CCND1 pathway.
 Wang et al., 2014


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024