Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
---|---|---|---|---|---|---|
Gastric cancer | hsa-miR-9 | Gastric cancer tissue | Down | CUL4A | Upregulation of miR-9 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion. | Deng et al., 2016 |
Gastric cancer | hsa-miR-137 | Gastric cancer tissue | Down | CUL4A | Upregulation of miR-137 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion. | Deng et al., 2016 |
Breast cancer | hsa-miR-135b | Breast | LATS2 | MicroRNA-135b directly targets large tumor suppressor kinase 2, a important component of the Hippo pathway. | Hua et al., 2016 | |
Breast cancer | hsa-miR-125a | MCF-7, MCF-10A, MCF-12A, MDA-MB-231 | Up | LIFR | MicroRNA-125a influences breast cancer stem cells by regulating Hippo signaling through targeting LIFR. | Nandy et al., 2015 |
Hepatocellular carcinoma | hsa-miR-186 | Hep-G2, SNU-398 | YAP1 | MicroRNA-186 suppresses hepatocellular carcinoma tumorigenesis through inhibiting the expression of YAP1. | Ruan et al., 2016 | |
Hepatocellular carcinoma | hsa-miR-338 | Hepatocyte | TAZ | TAZ is involved in the growth of hepatocellular carcinoma cells. Upregulation of miR-338 suppresses the expression of TAZ. | Liu et al., 2015 | |
Ovarian cancer | hsa-miR-129 | A2780, SK-OV-3, OVCAR, Caov-3 | YAP | MicroRNA-129 suppresses ovarian cancer cell proliferation, survival and tumorigenicity by down-regulating YAP expression. | Tan et al., 2015 | |
Pancreatic carcinoma | hsa-miR-181c | PANC-1, BxPC-3 | Up | Over-expression of miR-181c inactivates the Hippo signaling pathway in pancreatic carcinoma. | Chen et al., 2015 |