Pathway Name:

Hippo signaling pathway

microRNA Score: 0.0345

Gene Score: 0.0244

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Gastric cancer hsa-miR-9 Gastric cancer tissue Down CUL4A Upregulation of miR-9 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion.
Deng et al., 2016
Gastric cancer hsa-miR-137 Gastric cancer tissue Down CUL4A Upregulation of miR-137 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion.
Deng et al., 2016
Breast cancer hsa-miR-135b Breast LATS2 MicroRNA-135b directly targets large tumor suppressor kinase 2, a important component of the Hippo pathway.
Hua et al., 2016
Breast cancer hsa-miR-125a MCF-7, MCF-10A, MCF-12A, MDA-MB-231 Up LIFR MicroRNA-125a influences breast cancer stem cells by regulating Hippo signaling through targeting LIFR.
Nandy et al., 2015
Hepatocellular carcinoma hsa-miR-186 Hep-G2, SNU-398 YAP1 MicroRNA-186 suppresses hepatocellular carcinoma tumorigenesis through inhibiting the expression of YAP1.
Ruan et al., 2016
Hepatocellular carcinoma hsa-miR-338 Hepatocyte TAZ TAZ is involved in the growth of hepatocellular carcinoma cells. Upregulation of miR-338 suppresses the expression of TAZ.
Liu et al., 2015
Ovarian cancer hsa-miR-129 A2780, SK-OV-3, OVCAR, Caov-3 YAP MicroRNA-129 suppresses ovarian cancer cell proliferation, survival and tumorigenicity by down-regulating YAP expression.
Tan et al., 2015
Pancreatic carcinoma hsa-miR-181c PANC-1, BxPC-3 Up Over-expression of miR-181c inactivates the Hippo signaling pathway in pancreatic carcinoma.
Chen et al., 2015