| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-28 | Germinal Center B cells | Down | BAG1 | ERK pathway | hsa-miR-28 targets BCL2-associated athanogene (BAG1) involved in proliferation and apoptosis. BAG1 is an activator of the ERK pathway. | Schneider et al., 2014 |
| hsa-miR-96 | KM-H2, L-428, L-1236, SUP-HD1 | Up | FOXO1 | ERK pathway | hsa-miR-96 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| hsa-miR-182 | KM-H2, L-428, L-1236, SUP-HD1 | Up | FOXO1 | ERK pathway | hsa-miR-182 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| hsa-miR-183 | KM-H2, L-428, L-1236, SUP-HD1 | Up | FOXO1 | ERK pathway | hsa-miR-183 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma. | Xie et al., 2012 |
| hsa-miR-17 | Hodgkin Reed Sternberg cells | Up | CDKN1A | p53 signaling pathway | Overexpression of hsa-miR-17 is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma. | Gibcus et al., 2011 |
| hsa-miR-106b | Hodgkin Reed Sternberg cells | Up | CDKN1A | p53 signaling pathway | Overexpression of hsa-miR-106b is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma. | Gibcus et al., 2011 |
| hsa-miR-181a | SU-DHL-4, SU-DHL-10 | Up | BIM | Apoptosis pathway | Ectopic suppression of miR-181a inhibits cell adhesion dependent Bim down-regulation, resulting in cell apoptosis. hsa-miR-181a plays a significant role in the regulation of lymphoma survival and cell adhesion regulated drug resistance. | Lwin et al., 2010 |