Targeted Gene Name:

IRS1

microRNA Score: 0.0259

Pathway Score: 0.0492

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Pathway More Details References
Gastric cancer hsa-miR-1225 MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 Down Beta-catenin pathway MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway.
Zheng et al., 2016
Gastric cancer hsa-miR-1271 Stomach Down IRS1 signaling pathway Upregulation of miR-1271 suppresses the levels of IRS1, inhibits proliferation of cells, and sensitized cells to DDP-induced apoptosis.
Yang et al., 2014
Hepatocellular carcinoma hsa-miR-105 Hepatocyte Down PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of IRS1 of PI3K-Akt signaling pathway.
Shen et al., 2014
Prostate cancer hsa-miR-200c DU145, PC-3 Down IRS1 signaling pathway MicroRNA-200c inhibits prostate cancer cell growth by suppressing IRS1 expression.
Su et al., 2015
Laryngeal squamous cell carcinoma hsa-miR-144 HEp-2 Down PI3K-Akt signaling pathway MicroRNA-144 acts as a tumor suppressor in laryngeal squamous cell carcinoma by down-regulating IRS1 expression.
Wu et al., 2016
Osteosarcoma hsa-miR-494 U2OS, MG-63, SaOS-2 Down PI3K-Akt signaling pathway MicroRNA-494 acts as a tumor suppressor in osteosarcoma by down-regulating IRS1 expression.
Zhi et al., 2016