Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
---|---|---|---|---|---|---|
Gastric cancer | hsa-miR-1225 | MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 | Down | Beta-catenin pathway | MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway. | Zheng et al., 2016 |
Gastric cancer | hsa-miR-1271 | Stomach | Down | IRS1 signaling pathway | Upregulation of miR-1271 suppresses the levels of IRS1, inhibits proliferation of cells, and sensitized cells to DDP-induced apoptosis. | Yang et al., 2014 |
Hepatocellular carcinoma | hsa-miR-105 | Hepatocyte | Down | PI3K-Akt signaling pathway | Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of IRS1 of PI3K-Akt signaling pathway. | Shen et al., 2014 |
Prostate cancer | hsa-miR-200c | DU145, PC-3 | Down | IRS1 signaling pathway | MicroRNA-200c inhibits prostate cancer cell growth by suppressing IRS1 expression. | Su et al., 2015 |
Laryngeal squamous cell carcinoma | hsa-miR-144 | HEp-2 | Down | PI3K-Akt signaling pathway | MicroRNA-144 acts as a tumor suppressor in laryngeal squamous cell carcinoma by down-regulating IRS1 expression. | Wu et al., 2016 |
Osteosarcoma | hsa-miR-494 | U2OS, MG-63, SaOS-2 | Down | PI3K-Akt signaling pathway | MicroRNA-494 acts as a tumor suppressor in osteosarcoma by down-regulating IRS1 expression. | Zhi et al., 2016 |