| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | hsa-miR-432 | Hepatocyte | Down | Wnt signaling pathway | Overexpression of hsa-miR-432 suppresses HCC cell proliferation by downregulating the expression of LRP6 of the Wnt signaling pathway. | Jiang et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-610 | Hepatocyte | Down | Wnt signaling pathway | Overexpression of hsa-miR-610 suppresses hepatocellular carcinoma cell proliferation and tumorigenicity. hsa-miR-610 directly targets LRP6 , which results in activation of WNT-beta catenin activity. | Zeng et al., 2014 |
| Papillary thyroid carcinoma | hsa-miR-126 | TPC-1, K1 | Down | Wnt signaling pathway | MicroRNA-126 acts as a tumor-suppressive microRNA by down-regulating LRP6 expression through Wnt signaling pathway. | Wen et al., 2015 |
| Myocarditis | hsa-miR-126 | HeLa | Up | Wnt signaling pathway | hsa-miR-126 expression promotes GSK-3-beta activity and induces degradation of beta-catenin through inhibiting LRP6, the targets in the Wnt signaling pathway. | Ye et al., 2013 |