| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | hsa-miR-224 | Gastric cancer tissue | Up | mTOR pathway | MicroRNA-224 down-regulates the expression of mTOR, leads to the activation of cell proliferation in gastric cancer. | Zhang et al., 2016 |
| Gastric cancer | hsa-miR-101-2 | MKN28, MKN45, AGS | Down | PI3K-Akt signaling pathway | MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of mTOR in gastric cancer. | Riquelme et al., 2016 |
| Gastric cancer | hsa-miR-199a | Stomach | Down | mTOR pathway | Overexpression of miRNA-199a inhibits cancer cell proliferation through targeting the mTOR signaling pathway. | Peng et al., 2014 |
| Chondrosarcoma | hsa-miR-100 | CHON-001 | Down | mTOR pathway | MicroRNA-100 functions as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance through down-regulating the expression of mTOR. | Zhu et al., 2014 |
| Hepatocellular carcinoma | hsa-miR-125a | Hep-G2, LM3 | Down | PI3K-Akt signaling pathway | Over-expression of microRNA-125a inhibits the expression of mTOR. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway. | Tang et al., 2015 |
| Breast cancer | hsa-miR-99a | MCF-7, MDA-MB-231 | Down | mTOR pathway | MicroRNA-99a inhibits the breast cancer malignant cancer stem cell phenotype by suppressing the mTOR signaling pathway. | Yang et al., 2014 |
| Cervical cancer | hsa-miR-634 | Down | mTOR pathway | MicroRNA-634 promotes apoptosis and reduces cell proliferation in cervical cancer cells by inhibiting mTOR signaling pathway. | Cong et al., 2016 | |
| Cervical cancer | hsa-miR-99a | HeLa | Down | mTOR pathway | Increased expression of miR-99a suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway. | Wang et al., 2014 |
| Cervical cancer | hsa-miR-99b | HeLa | Down | mTOR pathway | Increased expression of miR-99b suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway. | Wang et al., 2014 |
| Anaplastic thyroid carcinoma | hsa-miR-99a | SW1736, ARO, FRO | Down | mTOR pathway | MicroRNA-99a acts as a tumor suppressor and plays an important role in suppressing the tumorigenesis via targeting the mTOR/p- 4E-BP1/p-S6K1 pathway in anaplastic thyroid carcinoma. | Huang et al., 2015 |