| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| B-cell lymphoma | hsa-miR-124 | Down | NF-Kappa B signaling pathway | Ectopic expression of p53 increases the miR-124 levels and suppresses MYC. Disruption of NF-Kappa B signaling pathway may be associated with abnormal coexpression of MYC and poor prognosis in B-cell lymphoma. | Jeong et al., 2015 | |
| T-cell acute lymphoblastic leukemia | hsa-miR-451 | T-ALL cell lines | Down | Notch signaling pathway | hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia. | Li et al., 2011 |
| Hepatocellular carcinoma | hsa-miR-34a | Hepatocyte | Down | Myc pathway | hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma. | Xu et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-148b | Hepatocyte | Down | Wnt signaling pathway | hsa-miR-148b suppresses the expression of c-Myc. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway. | Zhang et al., 2015 |