| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-34a | L-02 | Up | SIRT1 | Lipid metabolism pathway | Overexpression of miR-34a suppresses the expression of SIRT1. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease. | Ding et al., 2015 |
| hsa-miR-34a | L-02 | Up | PPARA | Lipid metabolism pathway | Overexpression of miR-34a suppresses the expression of PPAR-alpha. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease. | Ding et al., 2015 |
| hsa-miR-21 | Hep-G2 | Up | HBP1 | p53 signaling pathway | MicroRNA-21 induces hepatic lipid accumulation through targeting Hbp1-p53-Srebp1c pathway. | Wu et al., 2015 |
| hsa-miR-34a | Hepatocyte | Up | HNF4 ALPHA | Lipid metabolism pathway | MicroRNA-34a suppresses very low-density lipoprotein secretion and induces liver steatosis and hypolipidemia through the miR-34a-HNF4-alpha pathway. | Xu et al., 2015 |
| hsa-miR-451 | Hep-G2 | Down | CAB39 | PI3K-Akt signaling pathway | Decreased expression of microRNA-451 is associated with suppression fatty acid-induced proinflammatory cytokine production via the AMPK/PI3K-Akt signaling pathway. | Hur et al., 2015 |
| hsa-miR-199a | Hep-G2 | Up | CAV1 | PPAR signaling pathway | Overexpression of miR199a in hepatocytes is associated with impaired FA beta-oxidation in mitochondria and aberrant lipid deposits through the PPAR signaling pathway. | Li et al., 2014 |
| hsa-miR-21 | Hep-G2 | Up | HBP1 | p53 signaling pathway | Downregulation of hsa-miR-21 increases expression of HBP1 and p53 and decreased lipogenesis. miR-21 stimulates hepatic lipid accumulation and cancer development through modulation of Hbp1-p53-Srebp1c pathway. | Wu et al., 2015 |