Pathway Name:

Notch signaling pathway

microRNA Score: 0.0647

Gene Score: 0.0457

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Cutaneous T-cell lymphoma hsa-miR-200c HuT 78, MyLa Down JAGGED1 Overexpression of miR-200c suppresses the expression of Jagged1, associated with reduction of Notch1 levels in cutaneous T-cell lymphomas.
 Gallardo et al., 2015
T-cell acute lymphoblastic leukemia hsa-miR-150 MOLT-3, Jurkat, CCRF-HSB-2 Up NOTCH3 Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia.
 Ghisi et al., 2011
T-cell acute lymphoblastic leukemia hsa-miR-451 T-ALL cell lines Down MYC hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia.
 Li et al., 2011
Hepatitis C virus infection hsa-miR-449a Hep-G2 Down NOTCH1 MicroRNA-449a plays an important role in regulating the expression of YKL40 through down-regulating NOTCH1 which is the components of the NOTCH signaling pathway.
 Sarma et al., 2012
Gastric cancer hsa-miR-151 SC-M1, AGS, NUGC-3, SNU-16, AZ-521, KATO III Up P53 Notch1/miR-151-5p axis regulates the progression of gastric cancer cells through targeting p53.
 Hsu et al., 2016
Gastric signet ring cell carcinoma hsa-miR-935 GES-1, AGS, MKN28, MKN45, KATO III, SGC-7901 Down NOTCH1 MicroRNA-935 suppresses gastric carcinoma cell proliferation, migration and invasion by directly inhibiting the expression of Notch1.
 Yan et al., 2016
Gastric cancer hsa-miR-23b AGS, NUGC-3, SNU-16, SC-M1, AZ-521 Down N2IC miR-23b inhibits tumor progression and pluripotency gene expression in gastric cancer cells through suppressing Notch2 receptor.
 Huang et al., 2015
Gastric cancer hsa-miR-100 MGC-803, HGC-27, GES-1 Up HS3ST2 Antagonism of miR-100 enhances the expression level of HS3ST2, results in the activation of the Notch-apoptosis pathway in tumor cells.
 Yang et al., 2015
Osteosarcoma hsa-miR-26a Zos Down JAGGED1 Upregulation of miR-26a inhibits the expression of Jagged1, one of the Notch ligand. MicroRNA-26a functions as tumor suppressor via suppression of Jagged1/Notch signaling.
 Lu et al., 2016
Breast cancer hsa-miR-101 Breast Down EYA1 MicroRNA-101 suppresses cell proliferation and promote apoptosis in breast cancer by down-regulating EYA1 via the Notch signaling pathway.
 Guan et al., 2016
Triple negative breast cancer hsa-miR-9 MDA-MB-231 Up NOTCH1 MicroRNA-9 elicits a suppressor-like activity in metastatic breast cancer cells by targeting Notch1.
 Mohammadi-Yeganeh et al., 2015
Breast cancer hsa-miR-34a MCF-7 Down NOTCH1 MicroRNA-34a suppresses breast cancer stemness and enhances the chemosensitivity to paclitaxel by targeting the Notch1 pathway.
 Kang et al., 2015
Cervical cancer hsa-miR-34a HeLa, Ca Ski, SiHa Down NOTCH1 MicroRNA-34a suppresses invasiveness in cervical cancer through targeting the Notch pathway.
 Pang et al., 2010
Choriocarcinoma hsa-miR-34a BeWo, JAR Down NOTCH1 MicroRNA-34a suppresses invasiveness in choriocarcinoma through targeting the Notch pathway.
 Pang et al., 2010
Osteosarcoma hsa-miR-26a Bone Down JAGGED1 MicroRNA-26a suppresses stem cell-like phenotype and tumor growth of osteosarcoma by down-regulating Jagged1 expression.
 Lu et al., 2016


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024