| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | More Details | References |
|---|---|---|---|---|---|---|
| Parkinson's disease | hsa-miR-7 | SH-SY5Y | Up | KEAP1 | MicroRNA-7 is upregulated in the brain, suppresses the expression of Keap1 in human neuroblastoma cells. Subsequently, this event activates Nrf2 pathway. | Kabaria et al., 2015 |
| Parkinson's disease | hsa-miR-153 | SH-SY5Y | Up | NRF2 | MicroRNA-153 directly targets Nrf2-antioxidant network which results an aberrant cellular survival events. | Narasimhan et al., 2014 |
| Hepatocellular carcinoma | hsa-miR-141 | Hepatocyte | Up | KEAP1 | Re-expression of hsa-miR-141 downregulates Keap1 expression, resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation and Nrf2-dependent antioxidant pathway reactivation in hepatocellular carcinoma cell. | Shi et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-340 | Hepatocyte | Down | NRF2 | hsa-miR-340 is associated with development of cisplatin resistance in hepatocellular carcinoma by suppressing Nrf2-dependent antioxidant pathway. | Shi et al., 2014 |