| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-26a | Zos | Down | JAGGED1 | Notch signaling pathway | Upregulation of miR-26a inhibits the expression of Jagged1, one of the Notch ligand. MicroRNA-26a functions as tumor suppressor via suppression of Jagged1/Notch signaling. | Lu et al., 2016 |
| hsa-miR-489 | Bone | Down | PAX3 | c-MET signaling pathway | MicroRNA-489 suppresses osteosarcoma metastasis by inhibiting PAX3 expression. | Liu et al., 2016 |
| hsa-miR-494 | U2OS, MG-63, SaOS-2 | Down | IRS1 | PI3K-Akt signaling pathway | MicroRNA-494 acts as a tumor suppressor in osteosarcoma by down-regulating IRS1 expression. | Zhi et al., 2016 |
| hsa-miR-506 | hFOB 1.19 | Down | AEG 1 | Wnt signaling pathway | MicroRNA-506 acts as a tumor suppressor by down-regulating AEG-1 expression in osteosarcoma through the regulation of the Wnt signaling pathway. | Yao et al., 2016 |
| hsa-miR-26a | Bone | Down | JAGGED1 | Notch signaling pathway | MicroRNA-26a suppresses stem cell-like phenotype and tumor growth of osteosarcoma by down-regulating Jagged1 expression. | Lu et al., 2016 |
| hsa-miR-20b | MG-63, U2OS | Down | HIF 1 ALPHA | VEGF signaling pathway | MicroRNA-20b inhibits cell invasion and proliferation by down-regulating the expression of HIF-1-alpha. | Liu et al., 2016 |
| hsa-miR-26a | MG-63, U2OS | Up | GSK 3 BETA | Wnt signaling pathway | MicroRNA-26a plays an important role in the proliferation of human osteosarcoma cells through regulating Wnt signaling pathway. | Qu et al., 2016 |
| hsa-miR-21 | MG-63 | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-21 plays an active role in osteosarcoma through PI3K-Akt signaling pathway by inhibiting PTEN expression. | Lv et al., 2016 |