mirWay : Search Results

Disease Name:

Ovarian Cancer

microRNA Score: 0.0948

Gene Score: 0.0671

Pathway Score: 0.1803

Micro RNA	Tissue/ Cell line	MicroRNA regulation	Targeted Member	Pathway	More Details	References
hsa-miR-150	SK-OV-3, SNU-119			PI3K-Akt signaling pathway	Decreased expression of miRNA-150 enhances pertuzumab resistance in ovarian cancer cells through AKT activation.	Wuerkenbieke et al., 2015
hsa-miR-106b	OVCAR-3	Down	RHOC	RhoC pathway	MicroRNA-106b suppresses tumorigenesis and progression of epithelial ovarian cancer by down-regulating the expression of RhoC.	Chen et al., 2015
hsa-miR-17	Ovary		LKB1	p53 signaling pathway	hsa-miR-17 regulates proliferation and invasion of ovarian tumor cells via targeting LKB1-p53-p21/WAF1 pathway.	Liu et al., 2015
hsa-miR-224	HO-8910, HO8910PM	Up	KLLN	KLLN-cyclin A pathway	Overexpression of microRNA-224 induces proliferation of ovarian cancer cells by down-regulating KLLN expression.	Hu et al., 2016
hsa-miR-203	IOSE-80, IOSE-144, OVCA429, OVCA433	Up	PDHB	Glycolysis pathway	MicroRNA-203 functions as an ocogene in ovarian cancer by inducing glycolysis.	Xiaohong et al., 2016
hsa-miR-23a	OVCA3, SK-OV-3	Up	ST7	MAPK signaling pathway	MicroRNA-23a suppresses proliferation, migration and invasion of epithelial ovarian cancer cells by down-regulating ST7 expression.	Yang et al., 2016
hsa-miR-133b	SK-OV-3, OVCAR3, HO-8910	Up	EGFR	PI3K-Akt signaling pathway	Upregulation of miR-133b suppresses proliferation and invasion of ovarian cancer cells through inhibition PI3K-Akt signaling pathways by down-regulating EGFR expression.	Liu et al., 2015
hsa-miR-634	A2780	Down	ERK2	RAS signaling pathway	MicroRNA-634 regains drug sensitivity in resistant ovarian cancer cells by down-regulating the RAS signaling pathway.	Jaarsveld et al., 2015
hsa-miR-1207	A2780, SK-OV-3, COV362	Up	SFRP1	Wnt signaling pathway	MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting SFRP1 by activating the Wnt signaling pathway in ovarian cancer.	Wu et al., 2015
hsa-miR-1207	A2780, SK-OV-3, COV362	Up	AXIN2	Wnt signaling pathway	MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting AXIN2 by activating the Wnt signaling pathway in ovarian cancer.	Wu et al., 2015
hsa-miR-1207	A2780, SK-OV-3, COV362	Up	ICAT	Wnt signaling pathway	MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting ICAT by activating the Wnt signaling pathway in ovarian cancer.	Wu et al., 2015
hsa-miR-140	A2780, SK-OV-3, OVCAR	Down	PDGFRA	miR-140-5p-PDGFRA pathway	Upregulation of miR-140 significantly suppresses ovarian cancer cell proliferation and promotes apoptosis by targeting PDGFRA.	Lan et al., 2015
hsa-miR-661	A2780, SK-OV-3, OVCAR	Up	INPP5J	PI3K-Akt signaling pathway	MicroRNA-661 functions as tumor promoter in ovarian cancer cells by down-regulates INPP5J expession.	Zhu et al., 2015
hsa-miR-150	SK-OV-3, SNU-119	Down		PI3K-Akt signaling pathway	Decreased expression of miRNA-150 regulates the pertuzumab resistance in ovarian cancer through PI3K-Akt signaling pathway.	Wuerkenbieke et al., 2015
hsa-miR-939	A2780, SK-OV-3, Caov-3	Up	APC2	Wnt signaling pathway	MicroRNA-939 acts as a potential tumor promoter by regulating the Wnt signaling pathway through inhibition of APC2 expression.	Ying et al., 2015
hsa-miR-129	A2780, SK-OV-3, OVCAR, Caov-3		YAP	Hippo signaling pathway	MicroRNA-129 suppresses ovarian cancer cell proliferation, survival and tumorigenicity by down-regulating YAP expression.	Tan et al., 2015
hsa-miR-197	Ovary	Up	NLK	Wnt signaling pathway	MicroRNA-197 promotes Taxol resistance in human ovarian cancer cells by down-regulating NLK expression.	Zou et al., 2015
hsa-miR-302b	SK-OV-3, OVCAR3	Down	RUNX1	Jak-STAT signaling pathway	MicroRNA-302b acts as a tumor suppressor in epithelial ovarian cancer by down-regulating RUNX1 expression and regulating the Jak-STAT signaling pathway.	Ge et al., 2014
hsa-miR-7	Ovary	Down	EGFR	PI3K-Akt signaling pathway	MicroRNA-7 suppresses tumor metastasis via PI3K-Akt signaling pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.	Zhou et al., 2014
hsa-miR-7	Ovary	Down	EGFR	ERK pathway	MicroRNA-7 suppresses tumor metastasis via ERK1/2 pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.	Zhou et al., 2014
hsa-miR-98	Ovary		EZH2	E2F Signaling pathway	MicroRNA-98 suppresses cell proliferation in human ovarian cancer stem cells through regulating the Rb/E2F pathway.	Liu et al., 2014
hsa-miR-9	SK-OV-3, OVCAR3, Caov-3	Down	TLN1	PI3K-Akt signaling pathway	MicroRNA-9 acts as a tumor suppressor in ovarian serous carcinoma by down-regulating TLN1 expression.	Tang et al., 2014
hsa-miR-141	A2780		KEAP1	NF-Kappa B signaling pathway	MicroRNA-141 down-regulates KEAP1 expression, and decreased expression of KEAP1 promotes cisplatin resistance in ovarian cancer.	Jaarsveld et al., 2013