| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Mantle cell lymphoma | hsa-miR-17-92 cluster | Z-138, Granta-519, JeKo-1 | Up | PI3K-Akt signaling pathway | Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PHLPP2 and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma. | Rao et al., 2012 |
| Hepatocellular carcinoma | hsa-miR-3127 | Hepatocyte | Up | PI3K-Akt signaling pathway | PHLPP1 and PHLPP2 are the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway. | Jiang et al., 2015 |