Pathway Name:

PI3K-Akt signaling pathway

microRNA Score: 0.6207

Gene Score: 0.439

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
T-cell lymphoblastic lymphoma hsa-miR-374b Jurkat, SUP-T1 Down AKT hsa-miR-374b inhibits proliferation and promotes apoptosis by downregulating the expression of AKT1 in T-cell lymphoblastic lymphoma.
 Qian et al., 2015
T-cell lymphoblastic lymphoma hsa-miR-374b Jurkat, SUP-T1 Down WNT16 hsa-miR-374b inhibits proliferation and promotes apoptosis by downregulating the expression of Wnt16 in T-cell lymphoblastic lymphoma.
 Qian et al., 2015
Diffuse Large B-cell lymphoma hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PTEN miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the PI3K-Akt signaling pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Nasal natural killer cell lymphoma hsa-miR-494 YT, NK-92 Up PTEN hsa-miR-494 suppresses the expression of PTEN with secondary induction of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma.
 Chen et al., 2015
Nasal natural killer cell lymphoma hsa-miR-142 YT, NK-92 Up RICTOR hsa-miR-142 suppresses the expression of RICTOR with secondary inhibition of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma.
 Chen et al., 2015
Diffuse Large B-cell lymphoma hsa-miR-124 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the PI3K-Akt signaling pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
Sezary syndrome hsa-miR-106b HuT 78, H9, HH Up PTEN Overexpression of hsa-miR-106b downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Sezary syndrome hsa-miR-21 HuT 78, H9, HH Up PTEN Overexpression of hsa-miR-21 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Sezary syndrome hsa-miR-486 HuT 78, H9, HH Up PTEN Overexpression of hsa-miR-486 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Diffuse Large B-cell lymphoma hsa-miR-21 CRL2631 Up PTEN hsa-miR-21 regulates the PI3K-Akt signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen.
 Bai et al., 2013
Diffuse Large B-cell lymphoma hsa-miR-155 CRL2631 Up PIK3R1 Overexpression of miR-155 activates PI3K-Akt signaling pathway through regulating PIK3R1 in in diffuse large B-cell lymphoma.
 Huang et al., 2012
Cutaneous T-cell lymphoma hsa-miR-122 MyLa, Se-Ax Up Overexpression of hsa-miR-122 decreases the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53.
 Manfe et al., 2012
Mantle cell lymphoma hsa-miR-17-92 cluster Z-138, Granta-519, JeKo-1 Up PHLPP2 Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PHLPP2 and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Mantle cell lymphoma hsa-miR-17-92 cluster Z-138, Granta-519, JeKo-1 Up PTEN Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PTEN and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Mantle cell lymphoma hsa-miR-17-92 cluster Z-138, Granta-519, JeKo-1 Up BIM Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting BIM and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Malignant lymphoma hsa-miR-150 Lymphoma cell lines Down DKC1 miR-150 directly targets DKC1, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
Malignant lymphoma hsa-miR-150 Lymphoma cell lines Down AKT miR-150 directly targets AKT2, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
T-cell leukemia hsa-miR-181a T-leukemia cell line Up miR-181a involves in acquired chemoresistance in T-cell leukemia. miR181a acts as a biomarker of T-cell leukemia via modulation of PI3K-Akt signaling pathway.
Yan et al., 2015
T-cell lymphoma hsa-miR-181a T-lymphoma cell line Up miR-181a involves in acquired chemoresistance in T-cell lymphoma. miR181a acts as a biomarker of T-cell lymphoma via modulation of PI3K-Akt signaling pathway.
Yan et al., 2015
Chronic lymphocytic leukemia hsa-miR-22 Peripheral blood Up PTEN Up-regulation of microRNA-22 is associated with suppression of phosphatase and tensin homolog (PTEN) and phosphoinositide 3-kinase (PI3K)/PI3K-Akt signaling pathway activation in chronic lymphocytic leukemia.
 Palacios et al., 2015
Acute myeloid leukemia hsa-miR-126 Peripheral blood, bone marrow Up miR-126 targets the PI3K-Akt signaling pathway, preserving acute myeloid leukemia stem cells quiescence and promoting chemotherapy resistance.
 Lechman et al., 2016
Alzheimer's disease hsa-miR-146a SH-SY5Y Up LRP2 Upregulation of miRNA-146a significantly suppresses Lrp2 ( Low-density lipoprotein receptor-related protein-2) expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby enhancing cell apoptosis.
 Zhang et al., 2016
Alzheimer's disease hsa-miR-132 Cerebral cortex Down PTEN MicroRNA-132 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Alzheimer's disease hsa-miR-212 Cerebral cortex Down PTEN MicroRNA-212 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Multiple myeloma hsa-miR-451 Multiple myeloma cell lines Up TSC1 MicroRNA-451 down-regulates TSC1 to mediate PI3K/Akt/mTOR signaling, which plays an important role in myeloma stem cell biology.
 Du et al., 2015
Hepatitis C virus infection hsa-miR-199a Huh-7.5.1 Up MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway.
 Wang et al., 2015
Hepatitis C virus infection hsa-miR-491 Huh-7 Down AKT MicroRNA-491 represses the phosphoinositol-3 (PI3) kinase/PI3K-Akt signaling pathway.
 Ishida et al., 2011
Gastric cancer hsa-miR-21 Gastric cancer tissue Up PTEN MicroRNA-21 enhances the phosphorylation of Akt through dropping PTEN which promotes the epithelial-mesenchymal transition in gastric cancer induced by TGF-beta 1.
 Liet al., 2016
Gastric cancer hsa-miR-31 SGC-7901 Down ITGA5 Over-expression of miR-31 suppresses the expression of ITGA5 and inhibits tumor cell invasion and metastasis by indirectly regulating PI3K-Akt signaling pathway in human gastric cancer cells.
 Zhang et al., 2016
Gastric cancer hsa-miR-29b - Up AKT The miR-29b controls cisplatin resistance of gastric cancer cell by suppressing PI3K-Akt signaling pathway.
 Chen et al., 2015
Gastric cancer hsa-miR-101-2 MKN28, MKN45, AGS Down MTOR MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of mTOR in gastric cancer.
 Riquelme et al., 2016
Gastric cancer hsa-miR-125b-2 MKN28, MKN45, AGS Down PIK3CB MicroRNA-125b-2 act as potential tumor suppressors by down-regulating the expression of PIK3CB in gastric cancer.
 Riquelme et al., 2016
Gastric cancer hsa-miR-451a MKN28, MKN45, AGS Down TSC1 MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of TSC1 in gastric cancer.
 Riquelme et al., 2016
Gastric cancer hsa-miR-203 SGC-7901, MGC-803, HGC-27, BGC-823 Down PIK3CA MicroRNA-203 suppresses cell proliferation and invasion in gastric cancer cells through directly inhibiting the PIK3CA expression.
 Liang et al., 2015
Hepatocellular carcinoma hsa-miR-133a Hepatocyte Down AKT Upregulation of miR-133a suppresses the activation of AKT signal pathway, which contributes to inhibition of hepatocellular carcinoma (HCC) cell growth. MicroRNA-133a acts as a tumor suppressor and represses survival of HCC cells by down-regulating IGF-1R.
 Zhang et al., 2015
Gastric cancer hsa-miR-338 Stomach Down ZEB2 MicroRNA-338 suppresses the epithelial mesenchymal transition progression in gastric cancer cells by inhibiting ZEB2 and MACC1/Met/Akt signaling pathway.
 Huang et al., 2015
Gastric cancer hsa-miR-144 Stomach Down MicroRNA-144 inhibits gastric cancer progression by directly suppressing MET expression, which represses activation of the PI3K-Akt signaling pathway.
 Liu et al., 2015
Gastric cancer hsa-miR-19a Stomach Up Upregulation of miR-19a induces the epithelial-mesenchymal transition through activating the PI3K-Akt signaling pathway.
 Lu et al., 2015
Gastric cancer hsa-miR-19a SGC-7901, NUGC-3 Up Upregulation of miR-19a increases the epithelial-mesenchymal transition via activating PI3K-Akt signaling pathway.
 Lu et al., 2014
Gastric cancer hsa-miR-137 MGC-803, HGC-27, MKN-45,SGC-7901 Down COX 2 MicroRNA-137 acts as a tumor suppressor through suppressing Cyclooxygenase-2 (Cox-2), which inhibits the activation of PI3K-Akt signaling pathway.
 Cheng et al., 2014
Gastric cancer hsa-miR-34a Stomach Down PDGFR MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating PDGFR via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway.
 Peng et al., 2014
Gastric cancer hsa-miR-34a Stomach Down MET MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating the expression of MET via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway.
 Peng et al., 2014
Gastric cancer hsa-miR-106a SGC-7901 Up PTEN MicroRNA-106a regulates cisplatin resistance in gastric cancer cells by targeting PI3K-Akt signaling pathway.
 Fang et al., 2013
Gastric cancer hsa-miR-34a SGC-7901 Down Upregulation of miR-34a promotes sensitivity of gastric cancer cells against cisplatin-based chemotherapies through PI3K-Akt signaling pathway.
 Cao et al., 2014
Gastric cancer hsa-miR-21 SGC-7901 Up PTEN hsa-miR-21 promotes cell survival and cisplatin resistance in gastric cancer through inhibiting phosphatase and tension homolog deleted on chromosome 10 (PTEN) expression level and activation of PI3K-Akt signaling pathway.
 Yang et al., 2013
Gastric cancer hsa-miR-10b MKN-45,GES-1 Up HOXD10 MicroRNA-10b promotes the phosphorylation of RhoC and AKT through down-regulating HOXD10, thus enhancing cell invasion in gastric tumors.
 Liu et al., 2012
Gastric cancer hsa-miR-335 Stomach Down SP1 MicroRNA-335 acts as a metastasis suppressor through down-regulating SP1 directly and indirectly via the Bcl-w-induced phosphoinositide 3-kinase-Akt-Sp1 pathway in gastric cancer.
 Xu et al., 2012
Non-alcoholic fatty liver disease hsa-miR-451 Hep-G2 Down CAB39 Decreased expression of microRNA-451 is associated with suppression fatty acid-induced proinflammatory cytokine production via the AMPK/PI3K-Akt signaling pathway.
 Hur et al., 2015
Non-small cell lung cancer hsa-miR-107 Lung Down BDNF MicroRNA-107 inhibits non-small cell lung cancer metastasis by down-regulating brain-derived neurotrophic factor and indirectly regulating PI3K-Akt signaling pathway.
 Xia et al., 2016
Non-small cell lung cancer hsa-miR-126 A-549 Down PIK3R2 Over-expression of miR-126 decreases the expression of the target gene PIK3R2 and regulates the PI3K-Akt signaling pathway, inhibiting the proliferation, migration, and invasion of non-small-cell lung cancer.
 Song et al., 2016
Chondrosarcoma hsa-miR-200b JJ012 Down VEGF A CCL5 enhances VEGF-dependent angiogenesis by suppressing miR-200b via PI3K-Akt signaling pathway in human chondrosarcoma cells.
 Liu et al., 2014
Lung cancer hsa-miR-128 A-549, SPC-A1, NCI-H460, NCI-H1299 PFKL Upregulation of miR-128 down-regulates phosphofructokinase liver type (PFKL) through a feedback loop that involves suppression of the AKT signaling pathway.
 Yang et al., 2016
Lung cancer hsa-miR-206 A-549 Down MET Upregulation of miR-206 decreases cisplatin resistance and epithelial-mesenchymal transition through inactivation of MET/PI3K-Akt signaling pathway.
 Chen et al., 2016
Non-small cell lung cancer hsa-miR-223 HCC827 Up Decreased expression of miR-223 is associated with resistance of non-small cell lung cancer cells to erlotinib through the activation of the IGF1R/phosphatidylinositol 3-kinase (PI3K)/PI3K-Akt signaling pathway.
 Han et al., 2016
Non-small cell lung cancer hsa-miR-452 Lung Down BMI 1 MicroRNA-452 inhibits non-small cell lung cancer cell epithelial-mesenchymal transition (EMT) through inactivating PI3K-Akt signaling pathway.
 Zhang et al., 2016
Metastatic lung cancer hsa-miR-708 Lung Down P21 Upregulation of the miRNA-708 inhibits cell survival and metastasis through its direct target p21, and suppresses the PI3K-Akt signaling pathway and stem cell-like characteristics of lung cancer cells.
 Wu et al., 2016
Non-small cell lung cancer hsa-miR-122 Lung Down MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor.
 Qin et al., 2015
Non-small cell lung cancer hsa-miR-26a Lung HMGA2 Down-regulation of miR-26a plays an important role in the mechanism of cisplatin resistance in human non-small cell lung cancer via HMGA2-mediated E2F1-PI3K-Akt signaling pathway.
 Yang et al., 2016
Non-small cell lung cancer hsa-miR-10a Lung Up PTEN Upregulation of miR-10a enhances non-small cell lung cancer cell proliferation, migration and invasion through targeting PTEN.
 Yu et al., 2015
Lung cancer hsa-miR-31 A-549 Up MET MicroRNA-31 suppresses the growth of lung adenocarcinoma cancer stem-like cells through inhibition of the MET-PI3K-Akt signaling pathway.
 Hou et al., 2016
Hepatocellular carcinoma hsa-miR-28 Hepatocyte Down IGF1 Decreased expression of miR-28 is associated with tumor growth via PI3K-Akt signaling pathway by down-regulating IGF1 in hepatocellular carcinoma.
 Shi et al., 2015
Non-small cell lung cancer hsa-miR-494 HUVEC PTEN MicroRNA-494 regulates angiogenesis by down-regulating PTEN and activates PI3K-Akt signaling pathway.
 Mao et al., 2015
Non-small cell lung cancer hsa-miR-30a Lung Down IGF1R MicroRNA-30a inhibits non-small cell lung cancer cells progression via PI3K-Akt signaling pathway by down-regulating the expression of IGF1R.
 Wen et al., 2015
Lung cancer hsa-miR-21 A-549 Up Inhibition of miR-21 reverses lung cancer cell multi drug resistance through inhibition of the Akt signaling pathway.
 Dong et al., 2015
Breast cancer hsa-miR-29a Breast Up PTEN MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting PTEN in breast cancer cells.
 Shen et al., 2016
Breast cancer hsa-miR-29a Breast Up GSK 3 BETA MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting GSK3-beta in breast cancer cells.
 Shen et al., 2016
Breast cancer hsa-miR-489 Breast Down SPIN1 MicroRNA-489 reverses the chemoresistance of breast cancer through the PI3K-PI3K-Akt signaling pathway by inhibiting SPIN1 expression.
 Chen et al., 2016
Breast cancer hsa-miR-10b MCF-7,MDA-MB-231, SK-BR-3 Up PTEN MicroRNA-10b regulates the self-renewal of the breast cancer stem cell phenotype through PI3K-Akt signaling pathway by targeting PTEN.
 Bahena-Ocampo et al., 2016
Hepatocellular carcinoma hsa-miR-155 BEL-7402, Hep-G2, SMMC-7721 Up ARID2 MicroRNA-155 enhances tumor growth in hepatocellular carcinoma by inhibiting ARID2-mediated Akt phosphorylation pathway.
 Zhang et al., 2016
Breast cancer hsa-miR-214 Breast Up PTEN MicroRNA-214 functions as oncogene in breast cancer by inhibiting the PI3K-Akt signaling pathway.
 Wang et al., 2016
Breast cancer hsa-miR-21 MCF-7 PTEN MiR-21 regulates autophagy and apoptosis by suppression phosphatase and tensin homolog (PTEN) through targeting PI3K-Akt signaling pathway.
 Yu et al., 2016
Breast cancer hsa-miR-320a Breast Down RAB11A MicroRNA-320a functions as a tumor suppressor in breast cancer by targeting Rab11a through activation of the Akt signaling pathway.
 Wang et al., 2015
Breast cancer hsa-miR-497 HUVEC VEGFR2 MicroRNA-497 suppresses tumor angiogenesis and growth through down-regulating VEGFR2 expression in breast cancer.
 Tu et al., 2015
Ovarian cancer hsa-miR-150 SK-OV-3, SNU-119 Decreased expression of miRNA-150 enhances pertuzumab resistance in ovarian cancer cells through AKT activation.
 Wuerkenbieke et al., 2015
Breast cancer hsa-miR-21 4T1 Up PTEN MicroRNA-21 functions as a fine tuner in the regulation of PI3K-Akt signaling pathway in the expansion of CCR6(+) Tregs in tumor sites.
 Hu et al., 2015
Breast cancer hsa-miR-542 MCF-7, SK-BR-3 Decreased expression of miRNA-542 is associated with trastuzumab resistance in breast cancer through regulating the PI3K-Akt signaling pathway.
 Ma et al., 2015
Hepatocellular carcinoma hsa-miR-370 Hep-G2, SMMC-7721, MHCC97 Down MicroRNA-370 suppresses liver cancer cell proliferation by regulating PI3K-Akt signaling pathway.
 Sun et al., 2016
Hepatocellular carcinoma hsa-miR-125a Hep-G2, LM3 Down PI3K MicroRNA-125a directly targets PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma hsa-miR-125a Hep-G2, LM3 Down AKT MicroRNA-125a down-regulates the expression of PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma hsa-miR-125a Hep-G2, LM3 Down MTOR Over-expression of microRNA-125a inhibits the expression of mTOR. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma hsa-miR-30a Hep-G2, SMMC-7721, MHCC97 Down MTDH MicroRNA-30a acts as a tumor suppressor by directly suppressing metadherin (MTDH) in hepatocellular carcinoma.
 Li et al., 2016
Hepatocellular carcinoma hsa-miR-16 SK-HEP-1 PI3K Upregulation of microRNA-16 suppresses PI3K expression and Akt phosphorylation. MicroRNA-16 overexpression inhibits the proliferation, invasion and metastasis of hepatocellular carcinoma cells, and these effects are associated with the PI3K-Akt signaling pathway.
 Wu et al., 2015
Hepatocellular carcinoma hsa-miR-21 Hepatocyte Up PTEN Overexpression of hsa-miR-21 reduces PTEN expression and sequential Akt activation. It suppresses autophagy through PI3K-Akt signaling pathway.
 He et al., 2015
Hepatocellular carcinoma hsa-miR-28 Hepatocyte IGF1 hsa-miR-28 directly targets the expression of insulin-like growth factor 1. Downregulation of miR-28 is associated with tumor proliferation and migration through PI3K-Akt signaling pathway by targeting IGF1.
 Shi et al., 2015
Hepatocellular carcinoma hsa-miR-133a Hepatocyte Down IGF 1R hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-9 Hepatocyte TAZ Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through PI3K-Akt signaling pathway.
 Higashi et al., 2015
Hepatocellular carcinoma hsa-miR-20a Hepatocyte Up PTEN Overexpression of hsa-miR-20a downregulates PTEN expression. Mir-20a promotes HCC cell radioresistance by activating the PTEN/PI3K-Akt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-26a Hepatocyte M CSF hsa-miR-26a downregulates M-CSF expression and inhibits macrophage recruitment via PI3K-Akt signaling pathway.
 Chai et al., 2015
Hepatocellular carcinoma hsa-miR-128 Hepatocyte Down PIK3R1 Overexpression of hsa-miR-128 suppress HCC cell proliferation by regulating PIK3R1 expression and PI3K-Akt signaling pathway.
 Huang et al., 2015
Hepatocellular carcinoma hsa-miR-429 Hepatocyte PTEN Overexpression of hsa-miR-429 directly targets PTEN expression. hsa-miR-429 promotes HCC cell migration and invasion through PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma hsa-miR-3127 Hepatocyte Up PHLPP2 PHLPP1 and PHLPP2 are the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-3127 Hepatocyte Up INPP4A INPP4A is the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-3127 Hepatocyte Up INPP5J INPP5J is the direct target of hsa-miR-3127. hsa-miR-3127 inhibits HCC cell proliferation and tumor growth by suppressing the PI3K-Akt signaling pathway.
Jiang et al., 2015
Hepatocellular carcinoma hsa-miR-1236 Hepatocyte Down AFP Overexpression of hsa-miR-1236 downregulates the expression of AFP, thus suppressing PTEN ubiquitination to up-regulate the expression of PTEN and leading to inhibition of the PI3K-Akt signaling pathway.
 Gao et al., 2015
Hepatocellular carcinoma hsa-miR-32 Hepatocyte Up PTEN hsa-miR-32 promotes hepatocellular carcinoma cell proliferation, migration and invasion via PI3K-Akt signaling pathway through targeting PTEN.
 Yan et al., 2015
Hepatocellular carcinoma hsa-miR-93 Hepatocyte Up PTEN hsa-miR-93 suppresses the expression of PTEN, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
Hepatocellular carcinoma hsa-miR-93 Hepatocyte Up CDKN1A hsa-miR-93 suppresses the expression of CDKN1A, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
Hepatocellular carcinoma hsa-miR-486 Hepatocyte Down PIK3R1 hsa-miR-486 inhibits hepatocellular carcinoma cell proliferation by downregulating PIK3R1 expression and suppressing PI3K-Akt signaling pathway activation.
 Huang et al., 2015
Hepatocellular carcinoma hsa-miR-29b LX-1, HSC-T6 Down PIK3R1 hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs).
 Wang et al., 2015
Hepatocellular carcinoma hsa-miR-29b LX-1, HSC-T6 Down AKT3 hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs).
 Wang et al., 2015
Hepatocellular carcinoma hsa-miR-105 Hepatocyte Down IRS1 Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of IRS1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma hsa-miR-105 Hepatocyte Down AKT Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of AKT1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma hsa-miR-105 Hepatocyte Down PDK1 Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of PDK1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma hsa-miR-218 Hepatocyte Down HOXA10 Overexpression of miR-218 reduces cancer cell proliferation in hepatocellular carcinoma through PI3K-Akt signaling pathway with possible association of HoxA10.
 Xiao et al., 2014
Hepatocellular carcinoma hsa-miR-222 Hepatocyte Up hsa-miR-222 affects cell proliferation, migration and invasion, and enhance the resistance of hepatocellular carcinoma cells to sorafenib via regulation of the PI3K-Akt signaling pathway.
 Liu et al., 2014
Hepatocellular carcinoma hsa-miR-185 Hepatocyte Down DNMT1 hsa-miR-185 acts as a tumor suppressor microRNA that prevents hepatocellular carcinoma cell growth by downregulating DNMT1, leading to PTEN induction and Akt inhibition.
 Qadir et al., 2014
Hepatocellular carcinoma hsa-miR-26a Hepatocyte PIK3C2 ALPHA MicroRNA-26a regulates angiogenesis of hepatocellular carcinoma through the PIK3C2-alpha/Akt/HIF-1-alpha/VEGFA pathway.
 Chai et al., 2014
Cervical cancer hsa-miR-21 HeLa, SiHa Up MicroRNA-21 confers reduced autophagy in cervical cancer cells through the PI3K-Akt signaling pathway.
 Song et al., 2016
Cervical cancer hsa-miR-181a End1/E6E7 Up MicroRNA-181a functions as an oncogene in cervical cancer. Reduced expression of miR-181a is associated with enhanced expression of PTEN and decreased phosphorylation of Akt and FOXO1.
 Xu et al., 2016
Cervical cancer hsa-miR-221 HeLa, SiHa Up PTEN MicroRNA-221 decreases the sensitivity of cervical cancer cells to gefitinib via the PI3K-Akt signaling pathway.
 Du et al., 2016
Cervical cancer hsa-miR-491 HeLa, SiHa, MS751 Down HTERT MicroRNA-491 inhibits cervical cancer cell growth through PI3K-Akt signaling pathway by down-regulating human telomerase reverse transcriptase (hTERT) expression.
 Zhou et al., 2016
Cervical cancer hsa-miR-494 HeLa, Ca Ski, SiHa Up PTEN MicroRNA-494 enhances proliferation of cervical cancer through targeting PTEN expression.
 Yang et al., 2015
Cervical cancer hsa-miR-196a HeLa, Ca Ski, SiHa Up FOXO1 MicroRNA-196a enhances cervical cancer proliferation through targeting FOXO1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Cervical cancer hsa-miR-196a HeLa, Ca Ski, SiHa Up P27KIP1 MicroRNA-196a enhances cervical cancer proliferation through targeting p27Kip1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Prostate cancer hsa-miR-4638 Prostate Down KIDINS220 MicroRNA-4638 suppresses castration resistance of prostate cancer via targeting Kidins220 and PI3K-Akt signaling pathway.
 Wang et al., 2016
Prostate cancer hsa-miR-7 PC-3 Down KLF4 MicroRNA-7 suppresses the stemness of prostate cancer stem-like cells and tumorigenesis through inhibiting KLF4/PI3K/Akt/p21 pathway.
 Chang et al., 2015
Prostate cancer hsa-miR-124 DU145, PC-3, 22Rv1 Down TALIN 1 MicroRNA-124 inhibits cellular adhesion and motility by targeting talin1 via the focal adhesion kinase/PI3K-Akt signaling pathway.
 Zhang et al., 2015
Prostate cancer hsa-miR-302a DU145, PC-3, 22Rv1 Down AKT MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway in prostate cancer.
 Zhang et al., 2015
Prostate cancer hsa-miR-302a DU145, PC-3, 22Rv1 Down AKT MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway.
 Zhang et al., 2015
Prostate cancer hsa-miR-188 DU145, PC-3, 22Rv1 Down LAPTM4B Overexpression of miR-188 suppresses the PI3K-Akt signaling pathway through the inhibition of LAPTM4B.
 Zhang et al., 2015
Ovarian cancer hsa-miR-133b SK-OV-3, OVCAR3, HO-8910 Up EGFR Upregulation of miR-133b suppresses proliferation and invasion of ovarian cancer cells through inhibition PI3K-Akt signaling pathways by down-regulating EGFR expression.
 Liu et al., 2015
Ovarian cancer hsa-miR-661 A2780, SK-OV-3, OVCAR Up INPP5J MicroRNA-661 functions as tumor promoter in ovarian cancer cells by down-regulates INPP5J expession.
 Zhu et al., 2015
Ovarian cancer hsa-miR-150 SK-OV-3, SNU-119 Down Decreased expression of miRNA-150 regulates the pertuzumab resistance in ovarian cancer through PI3K-Akt signaling pathway.
 Wuerkenbieke et al., 2015
Ovarian cancer hsa-miR-7 Ovary Down EGFR MicroRNA-7 suppresses tumor metastasis via PI3K-Akt signaling pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.
 Zhou et al., 2014
Ovarian cancer hsa-miR-9 SK-OV-3, OVCAR3, Caov-3 Down TLN1 MicroRNA-9 acts as a tumor suppressor in ovarian serous carcinoma by down-regulating TLN1 expression.
 Tang et al., 2014
Bladder cancer hsa-miR-126 BLS-1 Up PIK3R2 Upregulation of miR-126 inhibits proliferation, migration, and invasion and enhances apoptosis by down-regulating PIK3R2 expression through regulating PI3K-Akt signaling pathway in bladder cancer.
 Xiao et al., 2016
Bladder cancer hsa-miR-433 UM-UC-3, T24, 5637 Down MET MicroRNA-433 suppresses the epithelial-mesenchymal transition in bladder cancer by targeting c-Met through controlling PI3K-Akt signaling pathway.
 Xu et al., 2016
Bladder cancer hsa-miR-433 UM-UC-3, T24, 5637 Down CREB1 MicroRNA-433 suppresses the epithelial-mesenchymal transition in bladder cancer by targeting CREB1 through controlling PI3K-Akt signaling pathway.
 Xu et al., 2016
Bladder cancer hsa-miR-29c T24 Down MicroRNA-29c suppresses proliferation in human bladder cancer cell proliferation through PI3K-PI3K-Akt signaling pathway.
 Fan et al., 2014
Nasopharyngeal carcinoma hsa-miR-92a CNE-1, CNE-2 Up PTEN MicroRNA-92a induces metastasis of nasopharyngeal carcinoma by down-regulating the PI3K-Akt signaling pathway.
 Zhang et al., 2016
Nasopharyngeal carcinoma hsa-miR-141 HNE-1 Up PTEN MicroRNA-141 promotes cell proliferation and tumor formation in nasopharyngeal carcinoma through targeting PI3K-Akt signaling pathway.
 Liu et al., 2016
Nasopharyngeal carcinoma hsa-miR-93 CNE-1, CNE-2 Down TGFBR2 MicroRNA-93 enhances uncontrolled growth, invasion, metastasis of nasopharyngeal carcinoma through activating PI3K-Akt signaling pathway by inhibiting TGF-beta-R2 expression.
 Lyu et al., 2014
Laryngeal squamous cell carcinoma hsa-miR-132 HEp-2, AMC-HN-8 Up FOXO1 MicroRNA-132 functions as an oncogene in laryngeal squamous cell carcinoma by regulating the PI3K-Akt signaling pathway.
 Lian et al., 2016
Laryngeal squamous cell carcinoma hsa-miR-144 HEp-2 Down IRS1 MicroRNA-144 acts as a tumor suppressor in laryngeal squamous cell carcinoma by down-regulating IRS1 expression.
 Wu et al., 2016
Laryngeal squamous cell carcinoma hsa-miR-365a HEp-2 Up MicroRNA-365a functions as an oncomiR and enhances growth and metastasis in laryngeal squamous cell carcinoma through the PI3K-Akt signaling pathway.
 Geng et al., 2016
Laryngeal squamous cell carcinoma hsa-miR-340 HEp-2 Down EZH2 MicroRNA-340 suppresses laryngeal squamous cell carcinoma progression by down-regulating EZH2 expression through PI3K-Akt signaling pathway.
 Yu et al., 2016
Oral squamous cell carcinoma hsa-miR-194 SCC-9, SCC-25, Down AGK MicroRNA-194 acts as a potential tumor suppressor by targeting the PI3K-Akt signaling pathway.
 Chi et al., 2015
Papillary thyroid carcinoma hsa-miR-96 TPC-1, K1 Up FOXO1 MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway.
 Song et al., 2015
Papillary thyroid carcinoma hsa-miR-34a TPC-1 Up GAS1 MicroRNA-34a enhances proliferation and inhibits apoptosis in papillary thyroid carcinoma by targeting GAS1 through PI3K-Akt signaling pathway.
 Ma et al., 2013
Osteosarcoma hsa-miR-494 U2OS, MG-63, SaOS-2 Down IRS1 MicroRNA-494 acts as a tumor suppressor in osteosarcoma by down-regulating IRS1 expression.
 Zhi et al., 2016
Osteosarcoma hsa-miR-21 MG-63 Up PTEN MicroRNA-21 plays an active role in osteosarcoma through PI3K-Akt signaling pathway by inhibiting PTEN expression.
 Lv et al., 2016
Asthma hsa-miR-21 Airway smooth muscle Up PTEN MicroRNA-21 enhanced proliferation and migration of human airway smooth muscle (HASM) cell in asthma through activation of phosphoinositide 3 kinase pathway.
 Liu et al., 2015
Asthma hsa-miR-138 Airway smooth muscle PDK1 hsa-miR-138 controls ASMC proliferation through directly suppressing the PI3K-Akt signaling pathway.
 Liu et al., 2015
Asthma hsa-miR-10a Airway smooth muscle Up PIK3CA MicroRNA-10a regulates human airway smooth muscle cell proliferation through targeting PI3K-Akt signaling pathway.
 Hu et al., 2014


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024