Targeted Gene Name:

PTEN

microRNA Score: 0.181

Pathway Score: 0.3443

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Pathway More Details References
Diffuse Large B-cell lymphoma hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PI3K-Akt signaling pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the PI3K-Akt signaling pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Diffuse Large B-cell lymphoma hsa-miR-21 OCI-Ly1, OCI-Ly18, SU-DHL-7 Up mTOR pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the mTOR pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Nasal natural killer cell lymphoma hsa-miR-494 YT, NK-92 Up PI3K-Akt signaling pathway hsa-miR-494 suppresses the expression of PTEN with secondary induction of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma.
 Chen et al., 2015
Sezary syndrome hsa-miR-106b HuT 78, H9, HH Up PI3K-Akt signaling pathway Overexpression of hsa-miR-106b downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Sezary syndrome hsa-miR-21 HuT 78, H9, HH Up PI3K-Akt signaling pathway Overexpression of hsa-miR-21 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Sezary syndrome hsa-miR-486 HuT 78, H9, HH Up PI3K-Akt signaling pathway Overexpression of hsa-miR-486 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Diffuse Large B-cell lymphoma hsa-miR-21 CRL2631 Up PI3K-Akt signaling pathway hsa-miR-21 regulates the PI3K-Akt signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen.
 Bai et al., 2013
Mantle cell lymphoma hsa-miR-17-92 cluster Z-138, Granta-519, JeKo-1 Up PI3K-Akt signaling pathway Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PTEN and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Chronic lymphocytic leukemia hsa-miR-22 Peripheral blood Up PI3K-Akt signaling pathway Up-regulation of microRNA-22 is associated with suppression of phosphatase and tensin homolog (PTEN) and phosphoinositide 3-kinase (PI3K)/PI3K-Akt signaling pathway activation in chronic lymphocytic leukemia.
 Palacios et al., 2015
Alzheimer's disease hsa-miR-132 Cerebral cortex Down PI3K-Akt signaling pathway MicroRNA-132 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Alzheimer's disease hsa-miR-212 Cerebral cortex Down PI3K-Akt signaling pathway MicroRNA-212 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Gastric cancer hsa-miR-21 Gastric cancer tissue Up PI3K-Akt signaling pathway MicroRNA-21 enhances the phosphorylation of Akt through dropping PTEN which promotes the epithelial-mesenchymal transition in gastric cancer induced by TGF-beta 1.
 Liet al., 2016
Gastric cancer hsa-miR-370 Gastric cancer tissue Up PTEN pathway MicroRNA-370 down-regulates PTEN, leads to activation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorates gastric cancer growth and progression.
 Zeng et al., 2016
Gastric cancer hsa-miR-106a SGC-7901 Up PI3K-Akt signaling pathway MicroRNA-106a regulates cisplatin resistance in gastric cancer cells by targeting PI3K-Akt signaling pathway.
 Fang et al., 2013
Gastric cancer hsa-miR-21 SGC-7901 Up PI3K-Akt signaling pathway hsa-miR-21 promotes cell survival and cisplatin resistance in gastric cancer through inhibiting phosphatase and tension homolog deleted on chromosome 10 (PTEN) expression level and activation of PI3K-Akt signaling pathway.
 Yang et al., 2013
Laryngeal squamous cell carcinoma hsa-miR-744 Lung Up mTOR pathway Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating AKT/mTOR signaling pathway.
 Li et al., 2016
Non-small cell lung cancer hsa-miR-10a Lung Up PI3K-Akt signaling pathway Upregulation of miR-10a enhances non-small cell lung cancer cell proliferation, migration and invasion through targeting PTEN.
 Yu et al., 2015
Non-small cell lung cancer hsa-miR-494 HUVEC PI3K-Akt signaling pathway MicroRNA-494 regulates angiogenesis by down-regulating PTEN and activates PI3K-Akt signaling pathway.
 Mao et al., 2015
Non-small cell lung cancer hsa-miR-21 Lung Up NF-Kappa B signaling pathway Suppression of NF-Kappa B signaling pathway enhances cisplatin sensitivity in non-small cell lung cancer.
 Yang et al., 2015
Breast cancer hsa-miR-29a Breast Up PI3K-Akt signaling pathway MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting PTEN in breast cancer cells.
 Shen et al., 2016
Breast cancer hsa-miR-10b MCF-7,MDA-MB-231, SK-BR-3 Up PI3K-Akt signaling pathway MicroRNA-10b regulates the self-renewal of the breast cancer stem cell phenotype through PI3K-Akt signaling pathway by targeting PTEN.
 Bahena-Ocampo et al., 2016
Breast cancer hsa-miR-214 Breast Up PI3K-Akt signaling pathway MicroRNA-214 functions as oncogene in breast cancer by inhibiting the PI3K-Akt signaling pathway.
 Wang et al., 2016
Breast cancer hsa-miR-21 MCF-7 PI3K-Akt signaling pathway MiR-21 regulates autophagy and apoptosis by suppression phosphatase and tensin homolog (PTEN) through targeting PI3K-Akt signaling pathway.
 Yu et al., 2016
Breast cancer hsa-miR-21 4T1 Up PI3K-Akt signaling pathway MicroRNA-21 functions as a fine tuner in the regulation of PI3K-Akt signaling pathway in the expansion of CCR6(+) Tregs in tumor sites.
 Hu et al., 2015
Hepatocellular carcinoma hsa-miR-21 Hepatocyte Up PI3K-Akt signaling pathway Overexpression of hsa-miR-21 reduces PTEN expression and sequential Akt activation. It suppresses autophagy through PI3K-Akt signaling pathway.
 He et al., 2015
Glioblastoma hsa-miR-1908 SW1783, SW1088, SNB-19 Up PTEN pathway Overexpression of hsa-miR-1908 inhibits the expression of PTEN. miR-1908 acts as oncogene through repressing PTEN pathway.
 Xia et al., 2015
Hepatocellular carcinoma hsa-miR-20a Hepatocyte Up PI3K-Akt signaling pathway Overexpression of hsa-miR-20a downregulates PTEN expression. Mir-20a promotes HCC cell radioresistance by activating the PTEN/PI3K-Akt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma hsa-miR-429 Hepatocyte PI3K-Akt signaling pathway Overexpression of hsa-miR-429 directly targets PTEN expression. hsa-miR-429 promotes HCC cell migration and invasion through PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma hsa-miR-32 Hepatocyte Up PI3K-Akt signaling pathway hsa-miR-32 promotes hepatocellular carcinoma cell proliferation, migration and invasion via PI3K-Akt signaling pathway through targeting PTEN.
 Yan et al., 2015
Hepatocellular carcinoma hsa-miR-93 Hepatocyte Up PI3K-Akt signaling pathway hsa-miR-93 suppresses the expression of PTEN, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
Cervical cancer hsa-miR-130a HeLa, Ca Ski NF-Kappa B signaling pathway Overexpression of microRNA-130a regulates cervical cancer cell growth by inhibiting phosphatase and tensin homolog expression.
 Feng et al., 2016
Cervical cancer hsa-miR-221 HeLa, SiHa Up PI3K-Akt signaling pathway MicroRNA-221 decreases the sensitivity of cervical cancer cells to gefitinib via the PI3K-Akt signaling pathway.
 Du et al., 2016
Cervical cancer hsa-miR-21 HeLa, Ca Ski Up PTEN pathway MicroRNA-21 induces proliferation, migration and invasion in cervical cancer cells through targeting the PTEN expression.
 Xu et al., 2015
Cervical cancer hsa-miR-494 HeLa, Ca Ski, SiHa Up PI3K-Akt signaling pathway MicroRNA-494 enhances proliferation of cervical cancer through targeting PTEN expression.
 Yang et al., 2015
Prostate cancer hsa-miR-4534 DU145 Up PTEN pathway MicroRNA-4534 functions as an oncogenic microRNA and regulates PTEN pathway in prostate cancer.
 Nip et al., 2016
Nasopharyngeal carcinoma hsa-miR-92a CNE-1, CNE-2 Up PI3K-Akt signaling pathway MicroRNA-92a induces metastasis of nasopharyngeal carcinoma by down-regulating the PI3K-Akt signaling pathway.
 Zhang et al., 2016
Nasopharyngeal carcinoma hsa-miR-141 HNE-1 Up PI3K-Akt signaling pathway MicroRNA-141 promotes cell proliferation and tumor formation in nasopharyngeal carcinoma through targeting PI3K-Akt signaling pathway.
 Liu et al., 2016
Osteosarcoma hsa-miR-21 MG-63 Up PI3K-Akt signaling pathway MicroRNA-21 plays an active role in osteosarcoma through PI3K-Akt signaling pathway by inhibiting PTEN expression.
 Lv et al., 2016
Asthma hsa-miR-21 Airway smooth muscle Up PI3K-Akt signaling pathway MicroRNA-21 enhanced proliferation and migration of human airway smooth muscle (HASM) cell in asthma through activation of phosphoinositide 3 kinase pathway.
 Liu et al., 2015
Atherosclerosis hsa-miR-221 HUVEC PTEN pathway MiR-221 from human aortic smooth muscle cell-derived exosomes inhibits autophagy in HUVECs by modulating PTEN signaling pathway.
 Li et al., 2016
Atherosclerosis hsa-miR-222 HUVEC PTEN pathway MiR-221 from human aortic smooth muscle cell-derived exosomes inhibits autophagy in HUVECs by modulating PTEN signaling pathway.
 Li et al.,2016
Psoriasis hsa-miR-155 HaCat Up PTEN pathway Decreased expression of miR-155 significantly inhibits proliferation, migration, invasion and promotes apoptosis through PTEN singaling pathway in psoriasis cells.
 Xu et al., 2017


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024