| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-940 | SW1990 | Up | GSK 3 BETA | Wnt signaling pathway | Over-expression of miR-940 significantly represses GSK3-beta expression and enhances pancreatic carcinoma proliferation and invasion. | Yang et al., 2016 |
| hsa-miR-940 | SW1990 | Up | SFRP1 | Wnt signaling pathway | Over-expression of miR-940 significantly represses sFRP1 expression and enhances pancreatic carcinoma proliferation and invasion. | Yang et al., 2016 |
| hsa-miR-506 | PANC-1, BxPC-3, CFPAC-1 | Down | SPHK1 | NF-Kappa B signaling pathway | MicroRNA-506 acts as a tumor suppressor microRNA through NF-Kappa B signaling pathway. | Li et al., 2016 |
| hsa-miR-181c | PANC-1, BxPC-3 | Up | Hippo signaling pathway | Over-expression of miR-181c inactivates the Hippo signaling pathway in pancreatic carcinoma. | Chen et al., 2015 | |
| hsa-miR-744 | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | SFRP1 | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting secreted frizzled-related protein 1 (SFRP1), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
| hsa-miR-744 | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | GSK 3 BETA | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
| hsa-miR-744 | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | TLE3 | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting transducin-like enhancer of split 3 (TLE3), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
| hsa-miR-216a | PANC-1 | Down | JAK2 | Jak-STAT signaling pathway | MicroRNA-216a acts as a tumor suppressor in pancreatic cancer cells by inhibiting the Jak-STAT signaling pathway. | Hou et al., 2015 |
| hsa-miR-1181 | PANC-1, BxPC-3, CFPAC-1, Capan-1, Capan-2 | Down | STAT3 | Jak-STAT signaling pathway | MicroRNA-1181 downregulates STAT3 expression, resulting in inhibition of the Jak-STAT signaling pathway in pancreatic cancer. | Jiang et al., 2015 |