mirWay : Search Results

Disease Name:

Prostate Cancer

microRNA Score: 0.1164

Gene Score: 0.0823

Pathway Score: 0.2213

Micro RNA	Tissue/ Cell line	MicroRNA regulation	Targeted Member	Pathway	More Details	References
hsa-miR-144	Hep-G2, SK-BR-3	Up	RUNX1	Runx1 signaling	Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.	Vivacqua et al., 2015
hsa-miR-1297	DU145, PC-3, 22Rv1, LNCap	Down	AEG 1	Wnt signaling pathway	MicroRNA-1297 suppresses proliferation and invasion in prostate cancer by inhibiting AEG-1 expression.	Liang et al., 2016
hsa-miR-1207	LNCaP	Down	FNDC1	miRNA-1207-3p/FNDC1/FN1/AR regulatory pathway	Over-expression of microRNA-1207 suppresses proliferation, migration, and promotes apoptosis through inhibiting FNDC1 expression.	Das et al., 2016
hsa-miR-4534	DU145	Up	PTEN	PTEN pathway	MicroRNA-4534 functions as an oncogenic microRNA and regulates PTEN pathway in prostate cancer.	Nip et al., 2016
hsa-miR-135a-1	PC-3, DU145	Down	EGFR	EGFR signaling pathway	Hsa-miR-135a-1 suppresses cell growth and migration of prostate cancer by down-regulating EGFR expression.	Xu et al., 2016
hsa-miR-4638	Prostate	Down	KIDINS220	PI3K-Akt signaling pathway	MicroRNA-4638 suppresses castration resistance of prostate cancer via targeting Kidins220 and PI3K-Akt signaling pathway.	Wang et al., 2016
hsa-miR-30c	DU145	Down	BCL9	Wnt signaling pathway	MicroRNA-30c regulates prostate cancer progression by targeting BCL9, the key activator of the Wnt pathway.	Ling et al., 2016
hsa-miR-26b	LNCaP, DU145, PC-3	Down	ULK2	Autophagy pathway	MicroRNA-26b suppresses autophagy in prostate cancer cells by down-regulating ULK2 expression.	Clotaire et al., 2016
hsa-miR-205	LNCaP, DU145	Down	TP53INP1	Autophagy pathway	MicroRNA-205 inhibits autophagy and increases radiosensitivity of prostate cancer cells by down-regulating TP53INP1 expression.	Wang et al., 2016
hsa-miR-340	DU145, BPH-1, PC-3	Down	MDM2	p53 signaling pathway	MicroRNA-340 acts as a tumor suppressor via the p53 signaling pathway by inhibiting MDM2 expression in prostate cancer.	Huang et al., 2016
hsa-miR-617	LNCaP, DU145, PC-3	Down	FRIZZLED 7	Wnt signaling pathway	MicroRNA-613 suppresses proliferation and invasion in prostate cancer cell through down-regulating Frizzled7 expression.	Ren et al., 2016
hsa-miR-34a	LNCaP, DU145, PC-3	Down	ATG4B	mTOR pathway	MicroRNA-34a increases chemosensitivity in prostate cancer by inhibiting ATG4B-induced autophagy via AMPK/mTOR pathway.	Liao et al., 2016
hsa-miR-146a	Prostate	Down	ROCK1	ROCK pathway	MicroRNA-146a plays an important role in the process of androgen-independent prostate cancer cells apoptosis through regulation of ROCK pathway.	Xu et al., 2015
hsa-miR-497	PC-3	Down	IKK BETA	NF-Kappa B signaling pathway	MicroRNA-497 acts as a tumor suppressor in prostate cacer by targeting IKK-beta through NF-Kappa B signaling pathway.	Kong et al., 2015
hsa-miR-7	PC-3	Down	KLF4	PI3K-Akt signaling pathway	MicroRNA-7 suppresses the stemness of prostate cancer stem-like cells and tumorigenesis through inhibiting KLF4/PI3K/Akt/p21 pathway.	Chang et al., 2015
hsa-miR-130a	PC-3	Down	SLAIN1	Apoptosis pathway	Ectopic expression of microRNA-130a activates apoptotic signaling pathway in taxane-resistant prostate cancer cells via activation of caspase-8.	Fujita et al., 2015
hsa-miR-124	DU145, PC-3, 22Rv1	Down	TALIN 1	PI3K-Akt signaling pathway	MicroRNA-124 inhibits cellular adhesion and motility by targeting talin1 via the focal adhesion kinase/PI3K-Akt signaling pathway.	Zhang et al., 2015
hsa-miR-302a	DU145, PC-3, 22Rv1	Down	AKT	PI3K-Akt signaling pathway	MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway in prostate cancer.	Zhang et al., 2015
hsa-miR-302a	DU145, PC-3, 22Rv1	Down	AKT	PI3K-Akt signaling pathway	MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway.	Zhang et al., 2015
hsa-miR-188	DU145, PC-3, 22Rv1	Down	LAPTM4B	PI3K-Akt signaling pathway	Overexpression of miR-188 suppresses the PI3K-Akt signaling pathway through the inhibition of LAPTM4B.	Zhang et al., 2015
hsa-miR-23a	LNCaP, DU145, BPH-1	Down	PAK6	PAK6-LIMK1 signaling pathway	Decreased expression of microRNA-23a inhibits the metastasis by blocking the PAK6-LIMK1 signaling pathway in prostate cancer.	Cai et al., 2015
hsa-miR-200c	DU145, PC-3	Down	IRS1	IRS1 signaling pathway	MicroRNA-200c inhibits prostate cancer cell growth by suppressing IRS1 expression.	Su et al., 2015
hsa-miR-124	DU145, BPH-1		PACE4	PACE4 pathway	MicroRNA-124 shows antiproliferative and antiaggressive effects by inhibiting PACE4 expression in prostate cancer.	Kang et al., 2014
hsa-miR-29a	DU145, PC-3	Down	LAMC1	Laminin signaling pathway	MicroRNA-29a functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway.	Nishikawa et al., 2014
hsa-miR-29b	DU145, PC-3	Down	LAMC1	Laminin signaling pathway	MicroRNA-29b functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway	Nishikawa et al., 2014
hsa-miR-29c	DU145, PC-3	Down	LAMC1	Laminin signaling pathway	MicroRNA-29c functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway	Nishikawa et al., 2014
hsa-miR-494	LNCaP, DU145, PC-3	Down	CXCR4	miR-494-3p/CXCR4 pathway	MicroRNA-494 inhibits the proliferation, invasion and migration of prostate cancer cells through suppressing CXCR4 expression.	Shen et al., 2014