| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Chronic lymphocytic leukemia | hsa-miR-132 | Peripheral blood | Up | p53 signaling pathway | Up-regulation of hsa-miR-132 down-regulates the expression of SIRT1 and induces TP53-dependent apoptosis in chronic lymphocytic leukemia. | Dal et al., 2015 |
| Gastric cancer | hsa-miR-543 | BGC-823, AGS, GES-1 | Up | SIRT1 pathway | MicroRNA-543 induces gastric cancer cell proliferation by down-regulating the expression of SIRT1. | Li et al., 2016 |
| Gastric cancer | hsa-miR-204 | Stomach | Down | SIRT1 pathway | Down-regulation of miR-204 is associated with gastric cancer cell invasion via regulation of the SIRT1-LKB1 pathway. | Zhang et al., 2013 |
| Non-alcoholic fatty liver disease | hsa-miR-34a | L-02 | Up | Lipid metabolism pathway | Overexpression of miR-34a suppresses the expression of SIRT1. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease. | Ding et al., 2015 |
| Hepatocellular carcinoma | hsa-miR-449 | Hepatocyte | SREBP pathway | MicroRNA-449 inhibits SIRT1-SREBP signaling via downregulating expression of SIRT1 and re-programs lipogenesis and cholesterogenesis in hepatocellular carcinoma. | Zhang et al., 2014 | |
| Chronic pancreatitis | hsa-miR-217 | PANC-1, BxPC-3 | Down | SIRT1 pathway | Expression of miR-217 is significantly decreased in chronic pancreatitis cell and its expression is negatively correlated with SIRT1 expression. | Deng et al., 2014 |