Targeted Gene Name:

SMAD4

microRNA Score: 0.056

Pathway Score: 0.1066

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Pathway More Details References
Multiple sclerosis hsa-miR-27b COS-7 Up TGF-beta signaling pathway Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-708 COS-7 Up TGF-beta signaling pathway Upregulation of miR-708 inhibits the expression of SMAD4. MicroRNA-708 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-212 COS-7 Up TGF-beta signaling pathway Over-expression of miR-212 suppresses the expression of SMAD4. MicroRNA-212 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-500a COS-7 Up TGF-beta signaling pathway Upregulation of miR-500a targets SMAD4. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-27b COS-7 Up TGF-beta signaling pathway Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-128 COS-7 Up TGF-beta signaling pathway Over-expression of miR-128 suppresses the expression of SMAD4. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-141 COS-7 Up TGF-beta signaling pathway Upregulation of miR-141 inhibits the expression of SMAD4.MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-628 COS-7 Up TGF-beta signaling pathway Over-expression of miR-628 suppresses the expression of SMAD4. MicroRNA-628 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-103 COS-7 Up TGF-beta signaling pathway Upregulation of miR-103 suppresses the expression of SMAD4. MicroRNA-103 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Gastric cancer hsa-miR-199a SNU-16 Up TGF-beta signaling pathway Upregulation of miR-199a suppresses the ability of TGF-beta to induce gastric cancer cell growth arrest and apoptosis through targeting Smad4.
 Zhang et al., 2012
Non-small cell lung cancer hsa-miR-124 Lung Down TGF-beta signaling pathway The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis.
 Zu et al., 2016
Bladder cancer hsa-miR-182 UM-UC-3, T24 Up Wnt signaling pathway MicroRNA-182 functions as an oncogene by targeting Smad4 through activation of the Wnt signaling pathway in bladder cancer.
 Hirata et al., 2012
Papillary thyroid carcinoma hsa-miR-146b TPC-1, B-CPAP Up TGF-beta signaling pathway MicroRNA-146b regulates migration and invasion in papillary thyroid carcinoma by targeting SMAD4, a key protein in theTGF-beta signaling pathway.
 Lima et al., 2016


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024