Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
---|---|---|---|---|---|---|
Chronic hepatitis C virus infection | hsa-miR-21 | Huh-7.5 | Up | TGF-beta signaling pathway | MicroRNA-21 down-regulates the expression of SMAD7 and enhances TGF-beta signaling, leads to increase fibrogenesis. | Marquez et al., 2010 |
Gastric cancer | hsa-miR-106b | MKN45, KATO III | Up | TGF-beta signaling pathway | Upregulation of miR-106b regulates cancer stem-like cell properties, particularly epithelial-mesenchymal transition characteristics, via the TGF-beta signaling pathway. | Yu et al., 2014 |
Pancreatic ductal adenocarcinoma | hsa-miR-367 | PANC-1, BxPC-3 | TGF-beta signaling pathway | MicroRNA-367 enhances epithelial-to-mesenchymal transition in pancreatic cancer by inhibiting TGF-beta signaling pathway. | Zhu et al., 2015 | |
Atherosclerosis | hsa-miR-21 | Peripheral blood mononuclear cells | Up | TGF-beta signaling pathway | Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis. | Li et al., 2015 |