mirWay : Search Results

Disease Name:

Small Cell Lung Cancer

microRNA Score: 0.0043

Gene Score: 0.003

Pathway Score: 0.0082

Micro RNA	Tissue/ Cell line	MicroRNA regulation	Targeted Member	Pathway	More Details	References
hsa-miR-3666	A-549		SIRT7	Apoptosis pathway	MicroRNA-3666 down-regulates the expression of SIRT7 and suppresses non-small cell lung cancer cell growth by inducing the Apoptosis pathway.	Shi et al., 2016
hsa-miR-146a	Lung	Down	MIF	NF-Kappa B signaling pathway	Overexpression of miR-146a suppresses the expression of MIF and promotes the apoptosis of cancer cells via NF-Kappa B signaling pathway.	Wang et al., 2016
hsa-miR-107	Lung	Down	BDNF	PI3K-Akt signaling pathway	MicroRNA-107 inhibits non-small cell lung cancer metastasis by down-regulating brain-derived neurotrophic factor and indirectly regulating PI3K-Akt signaling pathway.	Xia et al., 2016
hsa-miR-106a	Lung	Up	ULK1	Autophagy pathway	MicroRNA-106a inhibits autophagy and increases sensitivity of lung cancer cells to Src inhibitors through miR-106a-ULK1 signaling pathway.	Rothschild et al., 2016
hsa-miR-126	A-549	Down	PIK3R2	PI3K-Akt signaling pathway	Over-expression of miR-126 decreases the expression of the target gene PIK3R2 and regulates the PI3K-Akt signaling pathway, inhibiting the proliferation, migration, and invasion of non-small-cell lung cancer.	Song et al., 2016
hsa-miR-223	PC-9		IGF 1R	IGF signaling pathway	MicroRNA-223 increases the acquired resistance of non-small cell lung cancer cells to erlotinib through inhibition of the IGF-1R/Akt/S6 signaling pathway.	Zhao et al., 2016
hsa-miR-376c	Lung		LRH 1	Wnt signaling pathway	MicroRNA-376c suppresses non-small cell lung cancer cell growth and invasion by inhibiting the expression of LRH-1.	Jiang et al., 2016
hsa-miR-194	Lung	Down	HNUDC	ERK pathway	Over-expression of miR-194 suppresses the expression of Mpl/ERK pathway proteins, and inhibits the mitosis and proliferation of non-small cell lung cancer cells.	Zhou et al., 2016
hsa-miR-223	HCC827	Up		PI3K-Akt signaling pathway	Decreased expression of miR-223 is associated with resistance of non-small cell lung cancer cells to erlotinib through the activation of the IGF1R/phosphatidylinositol 3-kinase (PI3K)/PI3K-Akt signaling pathway.	Han et al., 2016
hsa-miR-410	Lung		SLC34A2	Wnt signaling pathway	MicroRNA-410 functions as oncogene through inhibiting the expression of SLC34A2 via activating Wnt signaling pathway in non-small cell lung cancer.	Zhang et al., 2016
hsa-miR-26b	Lung	Down	MIEN1	NF-Kappa B signaling pathway	MicroRNA-26b inhibits non-small cell lung cancer metastasis by suppressing MIEN1 through NF-Kappa B signaling pathways.	Li et al., 2016
hsa-miR-124	Lung	Down	SMAD4	TGF-beta signaling pathway	The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis.	Zu et al., 2016
hsa-miR-208a	Lung	Up	P21	mTOR pathway	MicroRNA-208a regulates the proliferation and radiosensitivity of human lung cancer cells by direct inhibition of p21.	Tang et al., 2016
hsa-miR-452	Lung	Down	BMI 1	PI3K-Akt signaling pathway	MicroRNA-452 inhibits non-small cell lung cancer cell epithelial-mesenchymal transition (EMT) through inactivating PI3K-Akt signaling pathway.	Zhang et al., 2016
hsa-miR-122	Lung	Down		PI3K-Akt signaling pathway	MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor.	Qin et al., 2015
hsa-miR-7	Lung		SMARCD1	Apoptosis pathway	MicroRNA-7 suppresses p53-dependent apoptosis-related gene BAX (BCL2-associated X protein) and expression of p21 by interfering with the interaction between SMARCD1 and p53, thereby decreasing caspase3 cleavage and the downstream apoptosis cascades.	Hong et al., 2016
hsa-miR-26a	Lung		HMGA2	PI3K-Akt signaling pathway	Down-regulation of miR-26a plays an important role in the mechanism of cisplatin resistance in human non-small cell lung cancer via HMGA2-mediated E2F1-PI3K-Akt signaling pathway.	Yang et al., 2016
hsa-miR-582	Lung	Up	AXIN2	Wnt signaling pathway	Upregulation of miR-582 down-regulates the expression of AXIN2, the negative regulators of the Wnt signaling pathway.	Fang et al., 2015
hsa-miR-582	Lung	Up	DKK3	Wnt signaling pathway	Overexpressed miR-582 regulates lung cancer stem cell-like traits by activating Wnt-beta-catenin signaling through targeting DKK3.	Fang et al., 2015
hsa-miR-582	Lung	Up	SFRP1	Wnt signaling pathway	Increased expression of miR-582 inhibits the expression of SFRP1, the negative regulators of the Wnt signaling pathway.	Fang et al., 2015
hsa-miR-10a	Lung	Up	PTEN	PI3K-Akt signaling pathway	Upregulation of miR-10a enhances non-small cell lung cancer cell proliferation, migration and invasion through targeting PTEN.	Yu et al., 2015
hsa-miR-452	Lung	Down	BMI 1	BMI1 pathway	Overexpression of MiR-452 suppresses metastasis through targeting BMI1 in non-small cell lung cancer.	He et al., 2015
hsa-miR-224	Lung	Up	CASPASE 3	NF-Kappa B signaling pathway	MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP3.	Cui et al., 2015
hsa-miR-224	Lung	Up	CASPASE 7	NF-Kappa B signaling pathway	MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP7.	Cui et al., 2015
hsa-miR-34c	Lung	Down	PAC1	MAPK signaling pathway	Upregulation of miR-34c inhibits cell proliferation, colony formation, migration and invasion by suppressing PAC1/MAPK signaling pathway.	Zhou et al., 2015
hsa-miR-134	H69	Up	WWOX	ERK pathway	MicroRNA-134 regulates cell proliferation and inhibits apoptosis through the activation of ERK1/2 pathway.	Chen et al., 2015
hsa-miR-494	HUVEC		PTEN	PI3K-Akt signaling pathway	MicroRNA-494 regulates angiogenesis by down-regulating PTEN and activates PI3K-Akt signaling pathway.	Mao et al., 2015
hsa-miR-30a	Lung	Down	IGF1R	PI3K-Akt signaling pathway	MicroRNA-30a inhibits non-small cell lung cancer cells progression via PI3K-Akt signaling pathway by down-regulating the expression of IGF1R.	Wen et al., 2015
hsa-miR-675	Lung	Down	GPR55	GPR55 signaling pathway	MicroRNA-675 acts as a tumor suppressor through the inhibition of GPR55 in non-small cell lung cancer.	He et al., 2015
hsa-miR-21	Lung	Up	PTEN	NF-Kappa B signaling pathway	Suppression of NF-Kappa B signaling pathway enhances cisplatin sensitivity in non-small cell lung cancer.	Yang et al., 2015
hsa-miR-99a	Lung	Down	IGF 1R	IGF signaling pathway	MicroRNA-99a promotes proliferation, colony formation and migration through the IGF-1R pathway in non-small cell lung cancer.	Chen et al., 2015
hsa-miR-15a	A-549		TLR1	NF-Kappa B signaling pathway	MicroRNA-15a increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.	Lan et al., 2015
hsa-miR-16	A-549		TLR1	NF-Kappa B signaling pathway	MicroRNA-16 increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.	Lan et al., 2015
hsa-miR-16	Lung	Down	BCL 2	Caspase 3 pathway	Overexpression of miR-16 enhances paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2.	Chatterjee et al., 2015
hsa-miR-17	Lung	Down	BECLIN 1	Caspase 3 pathway	Upregulation of miR-17 decreases cytoprotective autophagy by down-regulating the expression of Beclin-1.	Chatterjee et al., 2015
hsa-miR-141	Lung	Down	CXCL1	CXCL1-CXCR2 pathway	MicroRNA-141 significantly suppresses tumor growth and metastasis by targeting CXCL1 in non-small cell lung cancer.	Lv et al., 2015
hsa-miR-3127	Lung	Down	ABL1	ERK pathway	MicroRNA-3127 expression levels are associated with dasatinib sensitivity in non-small cell lung cancer through the c-Abl/Ras/ERK pathway.	Sun et al., 2014
hsa-miR-548l	Lung	Down	AKT	AKT1 signaling pathway	miR-548l plays an important role in non-small cell lung cancer invasion and metastasis through AKT1.	Liu et al., 2015
hsa-miR-99a	Lung	Down	AKT	AKT1 signaling pathway	MicroRNA-99a plays an important role in the tumorigenesis and metastasis of non-small cell lung cancer by inhibiting AKT1 signaling pathway.	Yu et al., 2015