Disease Name:

T-Cell Acute Lymphoblastic Leukemia

microRNA Score: 0.0129

Gene Score: 0.0091

Pathway Score: 0.0246

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-19 Jurkat, MOLT-4 Up CYLD NF-Kappa B signaling pathway hsa-miR-19 regulates the expression of CYLD and controls NF-Kappa B expression in downstream signaling pathway in T-cell acute lymphoblastic leukemia.
Ye et al., 2012
hsa-miR-150 MOLT-3, Jurkat, CCRF-HSB-2 Up NOTCH3 Notch signaling pathway Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia.
Ghisi et al., 2011
hsa-miR-451 T-ALL cell lines Down MYC Notch signaling pathway hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia.
Li et al., 2011