Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
hsa-miR-19 | Jurkat, MOLT-4 | Up | CYLD | NF-Kappa B signaling pathway | hsa-miR-19 regulates the expression of CYLD and controls NF-Kappa B expression in downstream signaling pathway in T-cell acute lymphoblastic leukemia. | Ye et al., 2012 |
hsa-miR-150 | MOLT-3, Jurkat, CCRF-HSB-2 | Up | NOTCH3 | Notch signaling pathway | Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia. | Ghisi et al., 2011 |
hsa-miR-451 | T-ALL cell lines | Down | MYC | Notch signaling pathway | hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia. | Li et al., 2011 |