Pathway Name:

TGF-beta signaling pathway

microRNA Score: 0.181

Gene Score: 0.128

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Diffuse Large B-cell lymphoma hsa-miR-155 Ly1, Ly3, Ly10, Ly18, Ly19 Up SMAD5 Overexpression of hsa-miR-155 downregulates the expression of SMAD5, establishing a link between this miRNA, the TGF-beta signaling pathway, and lymphomagenesis.
 Rai et al., 2010
Alzheimer's disease hsa-miR-106b SH-SY5Y Up TGF BETA R2 MicroRNA-106b is involved in the pathogenesis of alzheimer's disease by regulating the expression of TGF-beta type II receptor (T-beta R II), thereby influencing TGF-beta signaling.
 Wang et al., 2010
Multiple sclerosis hsa-miR-27b COS-7 Up TGFBR1 Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-128 COS-7 Up TGFBR1 Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-141 COS-7 Up TGFBR1 Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-500a COS-7 Up TGFBR1 Over-expression of miR-500a downregulates the expression of TGFBR1. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-27b COS-7 Up SMAD4 Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-708 COS-7 Up SMAD4 Upregulation of miR-708 inhibits the expression of SMAD4. MicroRNA-708 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-212 COS-7 Up SMAD4 Over-expression of miR-212 suppresses the expression of SMAD4. MicroRNA-212 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-500a COS-7 Up SMAD4 Upregulation of miR-500a targets SMAD4. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-27b COS-7 Up SMAD4 Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-128 COS-7 Up SMAD4 Over-expression of miR-128 suppresses the expression of SMAD4. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-141 COS-7 Up SMAD4 Upregulation of miR-141 inhibits the expression of SMAD4.MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-628 COS-7 Up SMAD4 Over-expression of miR-628 suppresses the expression of SMAD4. MicroRNA-628 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-103 COS-7 Up SMAD4 Upregulation of miR-103 suppresses the expression of SMAD4. MicroRNA-103 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis hsa-miR-106b Treg cell Up TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-106b modulates theTGF-beta signaling pathway.
 De Santis et al., 2010
Multiple sclerosis hsa-miR-25 Treg cell Up TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-25 modulates theTGF-beta signaling pathway.
 De Santis et al., 2010
Chronic hepatitis C virus infection hsa-miR-21 Huh-7.5 Up SMAD7 MicroRNA-21 down-regulates the expression of SMAD7 and enhances TGF-beta signaling, leads to increase fibrogenesis.
 Marquez et al., 2010
Gastric cancer hsa-miR-181b SGC-7901, AGS, HGC-27, MKN-28, HEK293T Up TIMP3 MicroRNA-181b down-regulates the expression of Timp3 affecting TGF-beta-induced epithelial-to-mesenchymal transition (EMT) in gastric cancer.
 Zhou et al., 2016
Gastric cancer hsa-miR-130 Gastric cancer tissue Up TGFBR2 MicroRNA-130 acts as an oncogene and promotes cell proliferation by directly inhibiting the expression of TGF-beta-R2 in gastric cancer.
 Duan et al., 2016
Gastric cancer hsa-miR-106b MKN45, KATO III Up SMAD7 Upregulation of miR-106b regulates cancer stem-like cell properties, particularly epithelial-mesenchymal transition characteristics, via the TGF-beta signaling pathway.
 Yu et al., 2014
Gastric cancer hsa-miR-199a SNU-16 Up SMAD4 Upregulation of miR-199a suppresses the ability of TGF-beta to induce gastric cancer cell growth arrest and apoptosis through targeting Smad4.
 Zhang et al., 2012
Gastric cancer hsa-miR-106b AGS, SNU-16 Up E2F1 MicroRNA-106b alters the TGF-beta tumor suppressor pathway in gastric cancer.
 Petrocca et al., 2008
Gastric cancer hsa-miR-93 AGS, SNU-16 Up E2F1 MicroRNA-93 alters the TGF-beta tumor suppressor pathway in gastric cancer.
 Petrocca et al., 2008
Epithelial-mesenchymal transition hsa-miR-221 A-549, HBE Down HMGA2 Upregulation of miR?221 down-regulates HMGA2 to suppress BLM?induced pulmonary fibrosis through the TGF?beta1/Smad3 signaling pathway.
 Wang et al., 2016
Pancreatic ductal adenocarcinoma hsa-miR-323 Pancreas Down SMAD2 Down-regulation of miR-323 is associated with TGF-beta-induced aggressive phenotypes through modulation of SMAD2 expression in Pancreatic ductal adenocarcinoma.
 Wang et al., 2016
Pancreatic ductal adenocarcinoma hsa-miR-323 Pancreas Down SMAD3 Down-regulation of miR-323 is associated with TGF-beta-induced aggressive phenotypes through inhibition of SMAD3 expression in Pancreatic ductal adenocarcinoma.
 Wang et al., 2016
Non-small cell lung cancer hsa-miR-124 Lung Down SMAD4 The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis.
 Zu et al., 2016
Colorectal cancer hsa-miR-140 HCT 116 SMAD2 Hsa-miR-140 inhibits colorectal carcinoma progression and metastasis through the down-regulation of Smad2, a key player in theTGF-beta signaling pathway.
 Zhai et al., 2015
Lung cancer hsa-miR-10a A-549 Up MicroRNA-10a is the potential target for improving the effectiveness of lung cancer chemotherapy through the regulation of the TGF-beta/Smad2/STAT3/STAT5 pathway.
 Sun et al., 2015
Hepatocellular carcinoma hsa-miR-122 HUVEC TGFBR1 Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1.
 Yin et al., 2016
Hepatocellular carcinoma hsa-miR-208 Hep-G2, Hep-3B ARID2 Overexpression of hsa-miR-208 downregulates ARID2 expression.TGF-beta-1 activated miR-208 promotes HCC cell progression by targeting ARID2 via TGF-beta signaling pathway.
Yu et al., 2015
Colorectal cancer hsa-miR-140 HCT 116 Down SMAD2 hsa-miR-140 inhibit CRC progression and metastasis by directly targeting Smad2 which is a key element inTGF-beta signaling pathway.
 Zhai et al., 2015
Hepatocellular carcinoma hsa-miR-26b Hepatocyte Down USP9X Overexpression of miR-26b downregulates the expression of USP9X, which in turn affects epithelial-mesenchymal transition of hepatocellular carcinoma cells through TGF-beta signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma hsa-miR-148a Hepatocyte SMAD2 Overexpression of miR-148a inhibits the expression of SMAD2 and cancer stem cell-like properties in hepatocellular carcinoma cells throughTGF-beta signaling pathway.
 Jiang et al., 2014
Oral squamous cell carcinoma hsa-miR-455 OECM-1 Up UBE2B Over-expression of miR-455 increases the proliferation of oral squamous cancer cells by down-regulating UBE2B expression.
 Cheng et al., 2016
Papillary thyroid carcinoma hsa-miR-146b TPC-1, B-CPAP Up SMAD4 MicroRNA-146b regulates migration and invasion in papillary thyroid carcinoma by targeting SMAD4, a key protein in theTGF-beta signaling pathway.
 Lima et al., 2016
Pancreatic ductal adenocarcinoma hsa-miR-367 PANC-1, BxPC-3 SMAD7 MicroRNA-367 enhances epithelial-to-mesenchymal transition in pancreatic cancer by inhibiting TGF-beta signaling pathway.
 Zhu et al., 2015
Asthma hsa-miR-19a Bronchial epithelial cell Up TGFBR2 hsa-miR-19a increased bronchial epithelial cell proliferation in severe asthma through inhibiting TGF-beta receptor 2 mRNA level.
 Haj-salem et al., 2015
Heart failure hsa-miR-15 Left ventricular Up TGFBR1 Overexpression of hsa-miR-15 inhibits TGF-beta signaling pathway through downregulating the expression of TGFBR1.
 Tijsen et al., 2014
Atherosclerosis hsa-miR-21 Peripheral blood mononuclear cells Up TGFBR Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis.
 Li et al., 2015
Atherosclerosis hsa-miR-21 Peripheral blood mononuclear cells Up SMAD7 Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis.
 Li et al., 2015


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024