| Disease | Micro RNA | Tissue/ Cell line | MicroRNA regulation | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Multiple sclerosis | hsa-miR-27b | COS-7 | Up | TGF-beta signaling pathway | Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | hsa-miR-128 | COS-7 | Up | TGF-beta signaling pathway | Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | hsa-miR-141 | COS-7 | Up | TGF-beta signaling pathway | Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | hsa-miR-500a | COS-7 | Up | TGF-beta signaling pathway | Over-expression of miR-500a downregulates the expression of TGFBR1. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Hepatocellular carcinoma | hsa-miR-122 | HUVEC | TGF-beta signaling pathway | Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1. | Yin et al., 2016 | |
| Heart failure | hsa-miR-15 | Left ventricular | Up | TGF-beta signaling pathway | Overexpression of hsa-miR-15 inhibits TGF-beta signaling pathway through downregulating the expression of TGFBR1. | Tijsen et al., 2014 |