Disease Name:

Thyroid Carcinoma

microRNA Score: 0.0043

Gene Score: 0.003

Pathway Score: 0.0082

Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
hsa-miR-20b K1, TPC-1 Down SOS1 MAPK signaling pathway MicroRNA-20b regulates papillary thyroid carcinoma initiation, progression, and metastasis through targeting son of sevenless homolog 1 (SOS1).
Hong et al., 2016
hsa-miR-20b K1, TPC-1 Down ERK2 MAPK signaling pathway MicroRNA-20b suppresses the activity of the MAPK signaling pathway by targeting extracellular signal-regulated kinase 2 (ERK2). MiR-20b plays an important role in initiation, progression, and metastasis of papillary thyroid carcinoma.
Hong et al., 2016
hsa-miR-449 TPC-1, K1, IHH-4, CGTH-W-3 Down RET Beta-catenin pathway Up regulation of miR-449 suppresses the growth of papillary thyroid carcinoma by targeting the beta-catenin pathway.
Li et al., 2016
hsa-miR-1280 Thyroid gland Down ER ALPHA Estrogen signaling pathway MicroRNA-1280 functions as a tumor suppressor by down-regulating ER-alpha expression.
Meng et al., 2016
hsa-miR-146b TPC-1, B-CPAP Up SMAD4 TGF-beta signaling pathway MicroRNA-146b regulates migration and invasion in papillary thyroid carcinoma by targeting SMAD4, a key protein in theTGF-beta signaling pathway.
Lima et al., 2016
hsa-miR-96 TPC-1, K1 Up FOXO1 PI3K-Akt signaling pathway MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway.
Song et al., 2015
hsa-miR-126 TPC-1, K1 Down LRP6 Wnt signaling pathway MicroRNA-126 acts as a tumor-suppressive microRNA by down-regulating LRP6 expression through Wnt signaling pathway.
Wen et al., 2015
hsa-miR-99a SW1736, ARO, FRO Down MTOR mTOR pathway MicroRNA-99a acts as a tumor suppressor and plays an important role in suppressing the tumorigenesis via targeting the mTOR/p- 4E-BP1/p-S6K1 pathway in anaplastic thyroid carcinoma.
Huang et al., 2015
hsa-miR-34a TPC-1 Up GAS1 PI3K-Akt signaling pathway MicroRNA-34a enhances proliferation and inhibits apoptosis in papillary thyroid carcinoma by targeting GAS1 through PI3K-Akt signaling pathway.
Ma et al., 2013
hsa-miR-129 MZ-CRC-1, TT Down RET RET pathway MicroRNA-129 regulates the growth, apoptosis and migration of medullary thyroid carcinoma cells through down-regulating RET expression.
Duan et al., 2014
hsa-miR-21 Thyroid gland Up PDCD4 PDCD4 pathway MicroRNA-21 regulates the expression of PDCD4 in medullary thyroid carcinoma.
Pennelli et al., 2015
hsa-miR-17 Thyroid gland PTK6 ERK pathway MicroRNA-17 suppresses the S1P-induced cell migration in follicular thyroid carcinoma through the ERK pathway.
Zhao et al., 2015