microRNA Name:

hsa-miR-1

Gene Score: 0.0091

Pathway Score: 0.0246

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Hodgkin lymphoma KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 ERK pathway hsa-miR-182 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Hodgkin lymphoma KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 ERK pathway hsa-miR-183 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Hepatocellular carcinoma Hep-G2, SK-BR-3 Up RUNX1 Runx1 signaling Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.
 Vivacqua et al., 2015
Prostate cancer Hep-G2, SK-BR-3 Up RUNX1 Runx1 signaling Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.
 Vivacqua et al., 2015
Hodgkin lymphoma Hodgkin Reed Sternberg cells Up CDKN1A p53 signaling pathway Overexpression of hsa-miR-17 is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma.
 Gibcus et al., 2011
Hodgkin lymphoma Hodgkin Reed Sternberg cells Up CDKN1A p53 signaling pathway Overexpression of hsa-miR-106b is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma.
 Gibcus et al., 2011
Non-Hodgkin lymphoma SU-DHL-4, SU-DHL-10 Up BIM Apoptosis pathway Ectopic suppression of miR-181a inhibits cell adhesion dependent Bim down-regulation, resulting in cell apoptosis. hsa-miR-181a plays a significant role in the regulation of lymphoma survival and cell adhesion regulated drug resistance.
 Lwin et al., 2010
B-cell lymphoma Down MYC NF-Kappa B signaling pathway Ectopic expression of p53 increases the miR-124 levels and suppresses MYC. Disruption of NF-Kappa B signaling pathway may be associated with abnormal coexpression of MYC and poor prognosis in B-cell lymphoma.
 Jeong et al., 2015
B-cell lymphoma Down BCL2 NF-Kappa B signaling pathway Ectopic expression of p53 increases the miR-124 levels and suppresses BCL2. Disruption of NF-Kappa B signaling pathway may be associated with abnormal coexpression of BCL2 and poor prognosis in B-cell lymphoma.
 Jeong et al., 2015
Nasal natural killer cell lymphoma YT, NK-92 Up RICTOR PI3K-Akt signaling pathway hsa-miR-142 suppresses the expression of RICTOR with secondary inhibition of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma.
 Chen et al., 2015
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B PI3K-Akt signaling pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the PI3K-Akt signaling pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B mTOR pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the mTOR pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PDE4B MCL1 pathway MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the MCL1 pathway in diffuse large B cell lymphoma.
 Kim et al., 2015
Diffuse Large B-cell lymphoma Ly1, Ly3, Ly10, Ly18, Ly19 Up SMAD5 TGF-beta signaling pathway Overexpression of hsa-miR-155 downregulates the expression of SMAD5, establishing a link between this miRNA, the TGF-beta signaling pathway, and lymphomagenesis.
 Rai et al., 2010
Sezary syndrome HuT 78, H9, HH Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-106b downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Diffuse Large B-cell lymphoma CRL2631 Up PIK3R1 PI3K-Akt signaling pathway Overexpression of miR-155 activates PI3K-Akt signaling pathway through regulating PIK3R1 in in diffuse large B-cell lymphoma.
 Huang et al., 2012
Cutaneous T-cell lymphoma MyLa, Se-Ax Up PI3K-Akt signaling pathway Overexpression of hsa-miR-122 decreases the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53.
 Manfe et al., 2012
Mantle cell lymphoma Z-138, Granta-519, JeKo-1 Up PHLPP2 PI3K-Akt signaling pathway Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PHLPP2 and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Mantle cell lymphoma Z-138, Granta-519, JeKo-1 Up PTEN PI3K-Akt signaling pathway Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PTEN and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Mantle cell lymphoma Z-138, Granta-519, JeKo-1 Up BIM PI3K-Akt signaling pathway Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting BIM and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma.
 Rao et al., 2012
Anaplastic large cell lymphoma Karpas-299, SU-DHL-1, SUP-M2 Up FOXO1 Jak-STAT signaling pathway hsa-miR-135b downregulates FOXO1 in anaplastic large cell lymphoma pathogenesis. miR-135b acts as a downstream mediator of Jak-STAT signaling pathway.
 Matsuyama et al., 2011
Anaplastic large cell lymphoma Karpas-299, SU-DHL-1, SUP-M2 Up GATA3 Jak-STAT signaling pathway hsa-miR-135b downregulates GATA3, rendering the IL-17 producing immunophenotype to anaplastic large cell lymphoma. miR-135b acts as a downstream mediator of Jak-STAT signaling pathway.
 Matsuyama et al., 2011
Anaplastic large cell lymphoma Karpas-299, SU-DHL-1, SUP-M2 Up STAT6 Jak-STAT signaling pathway hsa-miR-135b downregulates STAT6, rendering the IL-17 producing immunophenotype to anaplastic large cell lymphoma. miR-135b acts as a downstream mediator of Jak-STAT signaling pathway.
 Matsuyama et al., 2011
Primary CNS lymphoma Lymph node Up Myc pathway Overexpression of hsa-miR-17 activates Myc pathway in primary CNS lymphomas.
 Fischer et al., 2011
Primary CNS lymphoma Lymph node Down Myc pathway Downregulation of hsa-miR-145 is associated with Myc pathway in primary CNS lymphomas.
 Fischer et al., 2011
Malignant lymphoma Lymphoma cell lines Down DKC1 PI3K-Akt signaling pathway miR-150 directly targets DKC1, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
Malignant lymphoma Lymphoma cell lines Down AKT PI3K-Akt signaling pathway miR-150 directly targets AKT2, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
T-cell leukemia T-leukemia cell line Up PI3K-Akt signaling pathway miR-181a involves in acquired chemoresistance in T-cell leukemia. miR181a acts as a biomarker of T-cell leukemia via modulation of PI3K-Akt signaling pathway.
Yan et al., 2015
T-cell lymphoma T-lymphoma cell line Up PI3K-Akt signaling pathway miR-181a involves in acquired chemoresistance in T-cell lymphoma. miR181a acts as a biomarker of T-cell lymphoma via modulation of PI3K-Akt signaling pathway.
Yan et al., 2015
T-cell leukemia Jurkat cell Up FADD Fas signaling pathway Ectopic expression of miR-128a confers Fas-resistance by directly suppressing Fas-associated protein with death domain (FADD).
 Yamada et al., 2014
T-cell acute lymphoblastic leukemia Jurkat, MOLT-4 Up CYLD NF-Kappa B signaling pathway hsa-miR-19 regulates the expression of CYLD and controls NF-Kappa B expression in downstream signaling pathway in T-cell acute lymphoblastic leukemia.
 Ye et al., 2012
T-cell acute lymphoblastic leukemia MOLT-3, Jurkat, CCRF-HSB-2 Up NOTCH3 Notch signaling pathway Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia.
 Ghisi et al., 2011
Acute lymphoblastic leukemia TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat Down CDK6 CDK pathway Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells.
 Agirre et al., 2009
Chronic lymphocytic leukemia MEC-2, BJAB Up QKI LPS signaling pathway miR-155 down-regulates expression of QKI at the onset of immune response to LPS. Overexpression of QKI increases IL-10 production, as well as the total amount of p38, while markedly impairing p38 phosphorylation.
 Tili et al., 2015
Chronic lymphocytic leukemia Peripheral blood Up SIRT1 p53 signaling pathway Up-regulation of hsa-miR-132 down-regulates the expression of SIRT1 and induces TP53-dependent apoptosis in chronic lymphocytic leukemia.
 Dal et al., 2015
Chronic lymphocytic leukemia Peripheral blood Down MCL1 MCL1 pathway p53 deletion results in a decrease of miR-15a, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia.
 Liu et al., 2014
Chronic lymphocytic leukemia Peripheral blood Down MCL1 MCL1 pathway p53 deletion results in a decrease of miR-16-1, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia.
 Liu et al., 2014
Chronic lymphocytic leukemia Peripheral blood Up Toll-like receptor signaling pathway miR-17-92 family regulates pro-survival and growth-promoting responses of chronic lymphocytic leukemia cells to TLR9 triggering.
 Bomben et al., 2012
B-cell chronic lymphocytic leukemia Peripheral blood Down TP53 p53 signaling pathway Over-expression of hsa-miR-15a suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis.
 Fabbri et al, 2011
B-cell chronic lymphocytic leukemia Peripheral blood Down TP53 p53 signaling pathway Over-expression of hsa-miR-16-1 suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis.
 Fabbri et al, 2011
Chronic lymphocytic leukemia Peripheral blood Down BCL2 Apoptosis pathway miR-15a downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia.
 Cimmino et al., 2005
Chronic lymphocytic leukemia Peripheral blood Down BCL2 Apoptosis pathway miR-16-1 downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia.
 Cimmino et al., 2005
Acute myeloid leukemia KG-1a, MV4-11, HL-60, HEK293T Up KRAS RAS signaling pathway hsa-miR-181a targets RAS signaling pathway through downregulating KRAS and decreases acute myeloid leukemia growth.
 Huang et al., 2016
Acute myeloid leukemia KG-1a, MV4-11, HL-60, HEK293T Up NRAS RAS signaling pathway hsa-miR-181a targets RAS signaling pathway through downregulating NRAS and decreases acute myeloid leukemia growth.
 Huang et al., 2016
Acute myeloid leukemia KG-1a, MV4-11, HL-60, HEK293T Up MAPK1 RAS signaling pathway hsa-miR-181a targets RAS signaling pathway through downregulating MAPK1 and decreases acute myeloid leukemia growth.
 Huang et al., 2016
Acute myeloid leukemia Peripheral blood, bone marrow Up PI3K-Akt signaling pathway miR-126 targets the PI3K-Akt signaling pathway, preserving acute myeloid leukemia stem cells quiescence and promoting chemotherapy resistance.
 Lechman et al., 2016
Alzheimer's disease SH-SY5Y Up LRP2 PI3K-Akt signaling pathway Upregulation of miRNA-146a significantly suppresses Lrp2 ( Low-density lipoprotein receptor-related protein-2) expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby enhancing cell apoptosis.
 Zhang et al., 2016
Alzheimer's disease HEK293 Up RARA GSK3 signaling pathway MicroRNA-138 increases tau phosphorylation by targeting the RARA/GSK-3-beta pathway.
 Wang et al., 2015
Alzheimer's disease Cerebral cortex Down PTEN PI3K-Akt signaling pathway MicroRNA-132 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Alzheimer's disease Cerebral cortex Down FOXO3A FoxO signaling pathway MicroRNA-132 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Alzheimer's disease SH-SY5Y Up TGF BETA R2 TGF-beta signaling pathway MicroRNA-106b is involved in the pathogenesis of alzheimer's disease by regulating the expression of TGF-beta type II receptor (T-beta R II), thereby influencing TGF-beta signaling.
 Wang et al., 2010
Parkinson's disease HEK293 Up NMDAR2 Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating NMDAR2.
 Kong et al., 2015
Parkinson's disease HEK293 Up D2R Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating D2R.
 Kong et al., 2015
Parkinson's disease HEK293 Up GABA B R3 Neuroactive ligand-receptor interaction pathway MicroRNA-137 directly regulates Neuroactive ligand-receptor interaction pathway through downregulating GABA-B-R3.
 Kong et al., 2015
Parkinson's disease HEK293 Up ALPHA SYNUCLEIN mTOR pathway MicroRNA-153 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.
 Fragkouli et al., 2014
Parkinson's disease SH-SY5Y Up NRF2 Nrf2 signaling pathway MicroRNA-153 directly targets Nrf2-antioxidant network which results an aberrant cellular survival events.
 Narasimhan et al., 2014
Multiple sclerosis COS-7 Up TGFBR1 TGF-beta signaling pathway Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis COS-7 Up TGFBR1 TGF-beta signaling pathway Upregulation of miR-141 downregulates the expression of TGFBR1. MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis COS-7 Up SMAD4 TGF-beta signaling pathway Over-expression of miR-128 suppresses the expression of SMAD4. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-141 inhibits the expression of SMAD4.MicroRNA-141 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-103 suppresses the expression of SMAD4. MicroRNA-103 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Multiple sclerosis Treg cell Up TGF-beta signaling pathway TGF-beta is associated with differentiation and maturation of T regulatory cells. MicroRNA-106b modulates theTGF-beta signaling pathway.
 De Santis et al., 2010
Post influenza bacterial pneumonia - Up IL-17 signaling pathway MicroRNA-155 controls host immune response to postviral bacterial pneumonia through IL-23/IL-17 pathway.
 Podsiad et al., 2016
Influenza virus A infection A-549 Up IL 6 RIG-I-dependent signaling pathway Exogenous upregulation of microRNA-136 is associated with RIG-I-dependent signaling pathway.
 Zhao et al., 2015
Hepatitis C virus infection Huh-7.5.1 Up PI3K-Akt signaling pathway MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway.
 Wang et al., 2015
Hepatitis C virus infection Huh-7.5.1 Up RAS signaling pathway MicroRNA-199a promotes HCV replication by regulating Ras/ERK pathway.
 Wang et al., 2015
Hepatitis C virus infection Huh-7.5.1 Up Wnt signaling pathway MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway.
 Wang et al., 2015
Hepatitis C virus infection Hep-G2 SREBP2 SREBP pathway Upregulation of microRNA-185 suppresses the expression of SREBP2 by HCV core protein.
 Li et al., 2015
Hepatitis C virus infection Peripheral blood monocyte Up Toll-like receptor signaling pathway MicroRNA-146a expression is abnormally enhanced in peripheral blood monocytes of HCV-infected patients. The Toll-like receptor signaling pathway takes part in the upregulation of miR-146a in monocytes stimulated with HCV core protein.
 Zhang et al., 2015
Hepatitis C virus infection Hep-G2 HCBP6 SREBP pathway Over-expression of microRNA-122 suppresses the expression of HCBP6 (hepatitis C virus core-binding protein 6) which modulates TG (Triglyceride) Homeostasis in Hepatocytes through the SREBP pathway.
 Gao et al., 2015
Hepatitis C virus infection Hep-G2 Down JAK1 IL-6-mediated signaling pathway MicroRNA-107 regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating JAK1.
 Sarma et al., 2014
Hepatitis C virus infection Hepatocyte Up APC Wnt signaling pathway Over-expression of microRNA-155 promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling pathway.
Zhang et al., 2012
Hepatitis C virus infection Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-146a by modulating Toll-like receptor signaling pathway.
 El-Ekiaby et al., 2012
Hepatitis C virus infection Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-155 by modulating Toll-like receptor signaling pathway.
 El-Ekiaby et al., 2012
Hepatitis C virus RNA abundance Hepatocyte Isoprenoid biosynthesis pathway MicroRNA-122 modulates viral RNA abundance independently of its effect on isoprenoid metabolism.
 Norman et al., 2010
Gastric cancer Gastric cancer tissue Up p53 signaling pathway MicroRNA-100 antagonism suppresses ubiquitin-mediated p53 protein degradation by activating RNF144B, an E3 ubiquitination ligase.
 Yang et al., 2016
Gastric cancer SGC-7901, AGS, HGC-27, MKN-28, HEK293T Up TIMP3 TGF-beta signaling pathway MicroRNA-181b down-regulates the expression of Timp3 affecting TGF-beta-induced epithelial-to-mesenchymal transition (EMT) in gastric cancer.
 Zhou et al., 2016
Gastric cancer HGC-27, HeLa, GES-1, U2OS Up FANCM Fanconi Anemia pathway MicroRNA-146a down-regulates the expression of FANCM, a component in the Fanconi Anemia pathway.
 Sundaravinayagam et al., 2016
Gastric cancer Gastric cancer tissue Up TGFBR2 TGF-beta signaling pathway MicroRNA-130 acts as an oncogene and promotes cell proliferation by directly inhibiting the expression of TGF-beta-R2 in gastric cancer.
 Duan et al., 2016
Gastric cancer SC-M1, AGS, NUGC-3, SNU-16, AZ-521, KATO III Up P53 Notch signaling pathway Notch1/miR-151-5p axis regulates the progression of gastric cancer cells through targeting p53.
 Hsu et al., 2016
Gastric cancer Gastric cancer tissue Up FAS Caspase 3 pathway MicroRNA-106a acts as an oncogene through down-regulating FAS in gastric cancer involving in promotion of cell growth and invasion.
 Zhu et al., 2016
Gastric cancer Gastric cancer tissue Down CUL4A Hippo signaling pathway Upregulation of miR-137 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion.
 Deng et al., 2016
Gastric cancer MKN28, AGS MEF2D Wnt signaling pathway MicroRNA-19 inhibits Wnt signaling pathway through targeting MEF2D in gastric cancer.
 Xu et al., 2016
Gastric cancer MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 Down IRS1 Beta-catenin pathway MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway.
 Zheng et al., 2016
Gastric cancer MGC-803, HGC-27 Down HIF 1 ALPHA Apoptosis pathway MicroRNA-18a induces gastric cancer cell apoptosis through the HIF-1-alpha/mitochondrial apoptosis pathway.
 Wu et al., 2015
Gastric cancer MKN28, MKN45, AGS Down MTOR PI3K-Akt signaling pathway MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of mTOR in gastric cancer.
 Riquelme et al., 2016
Gastric cancer MKN28, MKN45, AGS Down PIK3CB PI3K-Akt signaling pathway MicroRNA-125b-2 act as potential tumor suppressors by down-regulating the expression of PIK3CB in gastric cancer.
 Riquelme et al., 2016
Gastric cancer MGC-803, BGC-823, GES-1 Down TRIM29 Wnt signaling pathway Upregulation of miR-185 suppresses TRIM29 expression and activity of Wnt signaling pathway in gastric cancer.
 Qiu et al., 2015
Gastric cancer Stomach Up IRF2 p53 signaling pathway MicroRNA-18a regulates the expression of P53 by directly targeting IRF2 in gastric cancer.
 Chen et al., 2016
Hepatocellular carcinoma Hepatocyte Down AKT PI3K-Akt signaling pathway Upregulation of miR-133a suppresses the activation of AKT signal pathway, which contributes to inhibition of hepatocellular carcinoma (HCC) cell growth. MicroRNA-133a acts as a tumor suppressor and represses survival of HCC cells by down-regulating IGF-1R.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte Down ERK ERK pathway MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth.
 Zhang et al., 2015
Gastric cancer Stomach Down PI3K-Akt signaling pathway MicroRNA-144 inhibits gastric cancer progression by directly suppressing MET expression, which represses activation of the PI3K-Akt signaling pathway.
 Liu et al., 2015
Gastric cancer Stomach Up PI3K-Akt signaling pathway Upregulation of miR-19a induces the epithelial-mesenchymal transition through activating the PI3K-Akt signaling pathway.
 Lu et al., 2015
Gastric cancer AGS, SGC-7901 Down MET c-MET signaling pathway Upregulation of miR-1 in gastric cancer cells inhibits gastric cancer cell proliferation and migration by targeting MET.
 Han et al., 2015
Gastric cancer MGC-803, HGC-27, GES-1 Up HS3ST2 Notch signaling pathway Antagonism of miR-100 enhances the expression level of HS3ST2, results in the activation of the Notch-apoptosis pathway in tumor cells.
 Yang et al., 2015
Gastric cancer SGC-7901, NUGC-3 Up PI3K-Akt signaling pathway Upregulation of miR-19a increases the epithelial-mesenchymal transition via activating PI3K-Akt signaling pathway.
 Lu et al., 2014
Gastric cancer Stomach Up AP 2 ALPHA BCL-2 pathway MicroRNA-135a enhances BCL-2 through AP-2-alpha and consequently increases cell resistance to apoptosis.
Pan et al., 2014
Gastric cancer AGS, MKN45 Down JAK1 Jak-STAT signaling pathway Upregulation of miR-106b inhibits expression of JAK1. Gastric epithelial cells treated with H. pylori LPS may be susceptible to activation of JAK/STAT3 signal pathway.
 Ye et al., 2015
Gastric cancer AGS, MKN45 Down STAT3 Jak-STAT signaling pathway Over-expression of miR-106b suppresses the expression of STAT3. Gastric epithelial cells treated with H. pylori LPS may be susceptible to activation of JAK/STAT3 signal pathway.
 Ye et al., 2015
Gastric cancer MKN45, KATO III Up SMAD7 TGF-beta signaling pathway Upregulation of miR-106b regulates cancer stem-like cell properties, particularly epithelial-mesenchymal transition characteristics, via the TGF-beta signaling pathway.
 Yu et al., 2014
Gastric cancer Stomach Down CDC42 CDC42 pathway MicroRNA-133 acts as a negative regulator of CDC42 pathway in gastric cancer.
 Cheng et al., 2014
Gastric cancer BGC-823, HGC-27 Up FBXO31 CDK pathway MicroRNA-17 down-regulates the expression of FBXO31. FBXO31 causes G1 phase cell cycle arrest and induces the growth inhibitory role of gastric cancer.
 Zhang et al., 2014
Gastric cancer GC9811, GC9811-P, MKN28, GES-1 Up E CADHERIN Cadherin signaling pathway Suppression of miR-199a impairs the metastatic potential of gastric cancer cells. Upregulation of miR-199a-5p inhibits the expression of E-cadherin.
 Zhao et al., 2014
Gastric cancer MGC-803, HGC-27, MKN-45,SGC-7901 Down COX 2 PI3K-Akt signaling pathway MicroRNA-137 acts as a tumor suppressor through suppressing Cyclooxygenase-2 (Cox-2), which inhibits the activation of PI3K-Akt signaling pathway.
 Cheng et al., 2014
Gastric cancer Stomach Down IGF1R IRS1 signaling pathway MicrRNA-1271 regulates cisplatin resistance in human gastric cancer cells through inhibiting the IGF1R/IRS1 pathway.
 Yang et al., 2014
Gastric cancer Stomach Down IRS1 IRS1 signaling pathway Upregulation of miR-1271 suppresses the levels of IRS1, inhibits proliferation of cells, and sensitized cells to DDP-induced apoptosis.
 Yang et al., 2014
Gastric cancer SGC-7901 Up S6K1 mTOR pathway Overexpression of miR-18a decreases the phosphorylation of S6K1 and inactivates the mTOR pathway.
 Zheng et al., 2013
Gastric cancer SGC-7901 Up 4E BPl mTOR pathway Upregulation of miR-18a decreases the phosphorylation of 4E-BPI and inactivates the mTOR pathway.
 Zheng et al., 2013
Gastric cancer SGC-7901 Up PTEN PI3K-Akt signaling pathway MicroRNA-106a regulates cisplatin resistance in gastric cancer cells by targeting PI3K-Akt signaling pathway.
 Fang et al., 2013
Gastric cancer Stomach Down MTOR mTOR pathway Overexpression of miRNA-199a inhibits cancer cell proliferation through targeting the mTOR signaling pathway.
 Peng et al., 2014
Gastric cancer AGS, MKN-28, MKN-45 Down ZBTB2 p53 signaling pathway MicroRNA-149 acts as a tumor suppressor through down-regulating ZBTB2 in human gastric cancer.
 Wang et al., 2012
Gastric cancer SNU-638 Up COPS8 GPCR pathway Upregulation of miR-146a down-regulates expression of COPS8, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors.
 Crone et al., 2012
Gastric cancer SNU-638 Up CARD10 GPCR pathway Upregulation of miR-146a down-regulates expression of CARD10, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors.
 Crone et al., 2012
Gastric cancer SNU-16 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-199a suppresses the ability of TGF-beta to induce gastric cancer cell growth arrest and apoptosis through targeting Smad4.
 Zhang et al., 2012
Gastric cancer Stomach Up FAS Apoptosis pathway Upregulation of miR-106a functions as an oncogene in gastric carcinogenesis and impair Apoptosis pathway by inhibiting FAS.
 Wang et al., 2013
Gastric cancer MKN-45,GES-1 Up HOXD10 PI3K-Akt signaling pathway MicroRNA-10b promotes the phosphorylation of RhoC and AKT through down-regulating HOXD10, thus enhancing cell invasion in gastric tumors.
 Liu et al., 2012
Gastric cancer Stomach Down ERBB2 ErbB signaling pathway MicroRNA-125a inhibits the proliferation of gastric cancer cells through targeting ERBB2.
 Nishida et al., 2011
Gastric cancer AGS, SNU-16 Up E2F1 TGF-beta signaling pathway MicroRNA-106b alters the TGF-beta tumor suppressor pathway in gastric cancer.
 Petrocca et al., 2008
Non-alcoholic fatty liver disease Hep-G2 Up CAV1 PPAR signaling pathway Overexpression of miR199a in hepatocytes is associated with impaired FA beta-oxidation in mitochondria and aberrant lipid deposits through the PPAR signaling pathway.
 Li et al., 2014
Non-small cell lung cancer Lung Down MIF NF-Kappa B signaling pathway Overexpression of miR-146a suppresses the expression of MIF and promotes the apoptosis of cancer cells via NF-Kappa B signaling pathway.
 Wang et al., 2016
Non-small cell lung cancer Lung Down BDNF PI3K-Akt signaling pathway MicroRNA-107 inhibits non-small cell lung cancer metastasis by down-regulating brain-derived neurotrophic factor and indirectly regulating PI3K-Akt signaling pathway.
 Xia et al., 2016
Non-small cell lung cancer Lung Up ULK1 Autophagy pathway MicroRNA-106a inhibits autophagy and increases sensitivity of lung cancer cells to Src inhibitors through miR-106a-ULK1 signaling pathway.
 Rothschild et al., 2016
Non-small cell lung cancer A-549 Down PIK3R2 PI3K-Akt signaling pathway Over-expression of miR-126 decreases the expression of the target gene PIK3R2 and regulates the PI3K-Akt signaling pathway, inhibiting the proliferation, migration, and invasion of non-small-cell lung cancer.
 Song et al., 2016
Chondrosarcoma CHON-001 Down MTOR mTOR pathway MicroRNA-100 functions as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance through down-regulating the expression of mTOR.
 Zhu et al., 2014
Lung cancer A-549, SPC-A1, NCI-H460, NCI-H1299 PFKL PI3K-Akt signaling pathway Upregulation of miR-128 down-regulates phosphofructokinase liver type (PFKL) through a feedback loop that involves suppression of the AKT signaling pathway.
 Yang et al., 2016
Non-small cell lung cancer Lung Down HNUDC ERK pathway Over-expression of miR-194 suppresses the expression of Mpl/ERK pathway proteins, and inhibits the mitosis and proliferation of non-small cell lung cancer cells.
 Zhou et al., 2016
Non-small cell lung cancer Lung Down SMAD4 TGF-beta signaling pathway The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis.
 Zu et al., 2016
Non-small cell lung cancer Lung Down PI3K-Akt signaling pathway MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor.
 Qin et al., 2015
Lung cancer Lung Down ZEB1 Zeb1 signaling pathway Overexpression of miR-144 inhibits non-small cell lung cancers through down-regulating Zeb1.
 Pan et al., 2015
Non-small cell lung cancer Lung Up PTEN PI3K-Akt signaling pathway Upregulation of miR-10a enhances non-small cell lung cancer cell proliferation, migration and invasion through targeting PTEN.
 Yu et al., 2015
Small cell lung cancer H69 Up WWOX ERK pathway MicroRNA-134 regulates cell proliferation and inhibits apoptosis through the activation of ERK1/2 pathway.
 Chen et al., 2015
Colorectal cancer HCT 116 SMAD2 TGF-beta signaling pathway Hsa-miR-140 inhibits colorectal carcinoma progression and metastasis through the down-regulation of Smad2, a key player in theTGF-beta signaling pathway.
 Zhai et al., 2015
Lung cancer A-549 Up TGF-beta signaling pathway MicroRNA-10a is the potential target for improving the effectiveness of lung cancer chemotherapy through the regulation of the TGF-beta/Smad2/STAT3/STAT5 pathway.
 Sun et al., 2015
Lung cancer A-549 Down Wnt signaling pathway hsa-miR-145 suppresses lung cancer cell metastasis and epithelial mesenchymal transition through inhibiting the Oct4 mediated Wnt signaling pathway.
 Ling et al., 2015
Non-small cell lung cancer A-549 TLR1 NF-Kappa B signaling pathway MicroRNA-15a increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.
 Lan et al., 2015
Non-small cell lung cancer A-549 TLR1 NF-Kappa B signaling pathway MicroRNA-16 increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.
 Lan et al., 2015
Non-small cell lung cancer Lung Down BCL 2 Caspase 3 pathway Overexpression of miR-16 enhances paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2.
 Chatterjee et al., 2015
Non-small cell lung cancer Lung Down BECLIN 1 Caspase 3 pathway Upregulation of miR-17 decreases cytoprotective autophagy by down-regulating the expression of Beclin-1.
 Chatterjee et al., 2015
Non-small cell lung cancer Lung Down CXCL1 CXCL1-CXCR2 pathway MicroRNA-141 significantly suppresses tumor growth and metastasis by targeting CXCL1 in non-small cell lung cancer.
 Lv et al., 2015
Lung cancer HBE Up BASP1 Wnt signaling pathway MicroRNA-191 regulates the epithelial-mesenchymal transition and the cancer stem cell-like properties of transformed cells.
 Xu et al., 2015
Breast cancer MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway Upregulation of hsa-miR-19a is associated with reduced expression of BRCA2 in breast cancer.
Mogilyansky et al., 2016
Breast cancer MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 BRCA2 Homologous recombination DNA repair pathway MicroRNA-19b directly inhibits the expression of BRCA2 in breast cancer.
 Mogilyansky et al., 2016
Breast cancer Breast Up NF1 ROCK pathway MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting NF1.
 Knirsh et al., 2016
Breast cancer Breast Up HOXD10 ROCK pathway MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting HOXD10.
 Knirsh et al., 2016
Breast cancer Breast Down AKT Estrogen signaling pathway Upregulation of miR-124 inhibits tumor growth and angiogenesis in breast cancer by inhibiting AKT2 expression.
 Jiang et al., 2016
Breast cancer MCF-7,MDA-MB-231, SK-BR-3 Up PTEN PI3K-Akt signaling pathway MicroRNA-10b regulates the self-renewal of the breast cancer stem cell phenotype through PI3K-Akt signaling pathway by targeting PTEN.
 Bahena-Ocampo et al., 2016
Breast cancer Breast Down EYA1 Notch signaling pathway MicroRNA-101 suppresses cell proliferation and promote apoptosis in breast cancer by down-regulating EYA1 via the Notch signaling pathway.
 Guan et al., 2016
Hepatocellular carcinoma BEL-7402, Hep-G2, SMMC-7721 Up ARID2 PI3K-Akt signaling pathway MicroRNA-155 enhances tumor growth in hepatocellular carcinoma by inhibiting ARID2-mediated Akt phosphorylation pathway.
 Zhang et al., 2016
Breast cancer Breast Up GSK 3 BETA Wnt signaling pathway MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway.
 Tan et al., 2016
Breast cancer Breast LATS2 Hippo signaling pathway MicroRNA-135b directly targets large tumor suppressor kinase 2, a important component of the Hippo pathway.
 Hua et al., 2016
Breast cancer Breast Down mTOR pathway MicroRNA-147 inhibits the proliferation, invasion and migration of breast cancer cells through targeting the Akt/mTOR signaling pathway.
 Zhang et al., 2016
Breast cancer MCF-7, MDA-MB-231 Down WNT1 Wnt signaling pathway MicroRNA-148a inhibits the migration and invasion of breast cancer cells by down-regulating WNT-1 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
Breast cancer MCF-7, SK-BR-3 Up SOCS6 Jak-STAT signaling pathway MicroRNA-155 promotes TAM resistance in breast cancer by regulating SOCS6-STAT3 signaling pathway.
 Shen et al., 2015
Breast cancer Breast Up BIM miR-181b/Bim pathway MicroRNA-181b induces chemoresistance by regulating the expression of Bim in breast cancer.
 Zheng et al., 2016
Breast cancer Breast Down FZD8 Wnt signaling pathway MicroRNA-100 inhibits the migration and invasion of breast cancer cells by down-regulating FZD-8 and suppressing Wnt signaling pathway.
 Jiang et al., 2016
Breast cancer MCF-7, MDA-MB-231, SK-BR-3 Down FRIZZLED 7 Wnt signaling pathway MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the Frizzled 7 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
Breast cancer MCF-7, MDA-MB-231, SK-BR-3 Down TNKS2 Wnt signaling pathway MicroRNA-1 suppresses breast cancer stem cell stemness, proliferation and migration by down-regulating the TNKS2 to inhibit the Wnt signaling pathway.
 Liu et al., 2015
Breast cancer Breast Down PAK4 ERK pathway MicroRNA-199a inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Breast cancer Breast Down PAK4 ERK pathway MicroRNA-199b inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway.
 Li et al., 2015
Laryngeal squamous cell carcinoma Lung CDK8 Wnt signaling pathway MicroRNA-101 acts as a tumour repressor that directly suppresses CDK8 expression in laryngeal squamous cell carcinoma.
 Li et al., 2015
Breast cancer MCF-7 CXCR4 NF-Kappa B signaling pathway Down-regulation of microRNA-146a is associated with increased expression of CXCR4, TRAF6 and EGFR which further activates NF-Kappa B signaling pathway and enhances the proliferation, migration, invasion and anti-apoptotic activity.
 Zheng et al., 2015
Breast cancer MCF-7,SK-BR-3 RUNX1 Runx1 signaling Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression.
 Vivacqua et al., 2015
Ovarian cancer SK-OV-3, SNU-119 PI3K-Akt signaling pathway Decreased expression of miRNA-150 enhances pertuzumab resistance in ovarian cancer cells through AKT activation.
 Wuerkenbieke et al., 2015
Breast cancer MCF-7, MCF-10A, MCF-12A, MDA-MB-231 Up LIFR Hippo signaling pathway MicroRNA-125a influences breast cancer stem cells by regulating Hippo signaling through targeting LIFR.
 Nandy et al., 2015
Epithelial ovarian cancer OVCAR-3 Down RHOC RhoC pathway MicroRNA-106b suppresses tumorigenesis and progression of epithelial ovarian cancer by down-regulating the expression of RhoC.
 Chen et al., 2015
Breast cancer MCF-7 Down MCL1 Mitochondria-caspase-3 pathway Combined effect of miR-125b and doxorubicin causes the loss of mitochondrial membrane potential and mitochondria outer membrane permeability.
 Xie et al., 2015
Breast cancer MCF-7, MDA-MB-231 Up APC Wnt signaling pathway MicroRNA-142 regulates human breast cancer stem cell properties through activation of the Wnt signaling pathway.
 Isobe et al., 2014
Breast cancer MCF-7 Up MAPK signaling pathway Upregulation of microRNA-155 enhances tumorigenesis through modulating mitogen activated protein kinase signaling pathway.
 Martin et al., 2014
Hepatocellular carcinoma Hep-G2, SNU-398 YAP1 Hippo signaling pathway MicroRNA-186 suppresses hepatocellular carcinoma tumorigenesis through inhibiting the expression of YAP1.
 Ruan et al., 2016
Hepatocellular carcinoma HUVEC TGFBR1 TGF-beta signaling pathway Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1.
 Yin et al., 2016
Hepatocellular carcinoma SMMC-7721, SNU-449, HEK293T Down BLVRB NF-Kappa B signaling pathway MicroRNA-127 represses NF-Kappa B activity by directly inhibiting biliverdin reductase B (BLVRB) in hepatocellular carcinoma cells.
 Huan et al., 2016
Hepatocellular carcinoma HEK293T, Huh-7 Down SLC39A6 SNAIL pathway MicroRNA-192 inhibits the SNAIL pathway to reduce tumor metastasis in hepatocellular carcinoma cells.
 Lian et al., 2016
Hepatocellular carcinoma Hep-G2, LM3 Down PI3K PI3K-Akt signaling pathway MicroRNA-125a directly targets PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma Hep-G2, LM3 Down AKT PI3K-Akt signaling pathway MicroRNA-125a down-regulates the expression of PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma Hep-G2, LM3 Down MTOR PI3K-Akt signaling pathway Over-expression of microRNA-125a inhibits the expression of mTOR. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway.
 Tang et al., 2015
Hepatocellular carcinoma PLC/PRF/5 - PDK4 Glycolysis pathway miR-122 inhibits hepatocellular cancer stem cells phenotypes by regulating glycolysis via down-reguating PDK4.
 Song et al., 2015
Hepatocellular carcinoma SK-HEP-1 PI3K PI3K-Akt signaling pathway Upregulation of microRNA-16 suppresses PI3K expression and Akt phosphorylation. MicroRNA-16 overexpression inhibits the proliferation, invasion and metastasis of hepatocellular carcinoma cells, and these effects are associated with the PI3K-Akt signaling pathway.
 Wu et al., 2015
Esophageal squamous cell carcinoma Eca-109 Up RAGE RAGE pathway Upregulation of miR-185 inhibits migration and invasion and reduces the capacity to develop distal pulmonary metastases via the RAGE pathway.
 Jing et al., 2015
Glioblastoma SW1783, SW1088, SNB-19 Up PTEN PTEN pathway Overexpression of hsa-miR-1908 inhibits the expression of PTEN. miR-1908 acts as oncogene through repressing PTEN pathway.
 Xia et al., 2015
Hepatocellular carcinoma Hep-G2, SMMC-7721, Huh-7 Down PIK3R3 mTOR pathway Overexpression hsa-miR-132 inhibits PIK3R3 expression. miR-132 suppresses proliferation, invasion and migration of HCC through inactivating AKT/mTOR pathway
 Liu et al., 2015
Hepatocellular carcinoma Hepatocyte Down TRIM23 NF-Kappa B signaling pathway hsa-miR-23 directly targeted TRIM23. TNF alpha-NF-Kappa B signaling switches off negative regulation by repressing HNF-1 alpha-mediated expression of hsa-miR-194.
 Bao et al., 2015
Gastric cancer Stomach Up IRF2 p53 signaling pathway Overexpression of hsa-miR-18a downregulates the expression of IRF2. Mir-18a modulates p53 expression by targeting IRF2 and regulates p53 signaling in gastric cancer.
 Chen et al., 2016
Hepatocellular carcinoma Hepatocyte Down IGF 1R PI3K-Akt signaling pathway hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte Down IGF 1R ERK pathway hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte Down MCL1 Caspase 3 pathway Mcl-1 is the direct target of hsa-miR-193b and overexpression of hsa-miR-193b increased cancer cell sensitivity via caspase dependent apoptosis pathway.
 Yin et al., 2015
Colorectal cancer HCT 116 Down SMAD2 TGF-beta signaling pathway hsa-miR-140 inhibit CRC progression and metastasis by directly targeting Smad2 which is a key element inTGF-beta signaling pathway.
 Zhai et al., 2015
Hepatocellular carcinoma Hepatocyte Down PIK3R1 PI3K-Akt signaling pathway Overexpression of hsa-miR-128 suppress HCC cell proliferation by regulating PIK3R1 expression and PI3K-Akt signaling pathway.
 Huang et al., 2015
Hepatocellular carcinoma Hepatocyte Up KEAP1 Nrf2 signaling pathway Re-expression of hsa-miR-141 downregulates Keap1 expression, resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation and Nrf2-dependent antioxidant pathway reactivation in hepatocellular carcinoma cell.
 Shi et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGF 1R IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGFBP 3 IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGF-II IGF signaling pathway Overexpression of hsa-miR-182 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Down AFP PI3K-Akt signaling pathway Overexpression of hsa-miR-1236 downregulates the expression of AFP, thus suppressing PTEN ubiquitination to up-regulate the expression of PTEN and leading to inhibition of the PI3K-Akt signaling pathway.
 Gao et al., 2015
Hepatocellular carcinoma Hepatocyte Up WWOX Wnt signaling pathway Overexpression of hsa-miR-153 downregulates WWOX, a tumor suppressor and inhibitor of Wnt signaling pathway in hepatocellular carcinoma.
 Hua et al., 2015
Hepatocellular carcinoma Hepatocyte Down WNT1 Wnt signaling pathway hsa-miR-148b suppresses the expression of Wnt-1. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte Down BETA CATENIN Wnt signaling pathway hsa-miR-148b suppresses the expression of beta-catenin. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte Down MYC Wnt signaling pathway hsa-miR-148b suppresses the expression of c-Myc. Deregulated expression of hsa-miR-148b is associated with poor prognosis and aggressive phenotype of hepatocellular carcinoma through targeting Wnt signaling pathway.
 Zhang et al., 2015
Hepatocellular carcinoma Hepatocyte NFIB p53 signaling pathway p53 controls the expression of hsa-miR-1246 in hepatocellular carcinoma. hsa-miR-1246 directly targets nuclear factor I/B (NFIB). Overexpression of hsa-miR-1246 promotes cell proliferation, colony formation and apoptosis through modulating p53 signaling pathway in hepatocellular carcinoma.
 Zhang et al., 2015
Ovarian cancer Ovary LKB1 p53 signaling pathway hsa-miR-17 regulates proliferation and invasion of ovarian tumor cells via targeting LKB1-p53-p21/WAF1 pathway.
 Liu et al., 2015
Hepatocellular carcinoma Hepatocyte AKT mTOR pathway hsa-miR-149 acts as a tumor suppressive microRNA and play a vital role in suppressing hepatocellular carcinoma tumorigenesis by modulating by AKT/mTOR pathway.
Zhang et al., 2014
Hepatocellular carcinoma Hepatocyte Down IRS1 PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of IRS1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma Hepatocyte Down AKT PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of AKT1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma Hepatocyte Down PDK1 PI3K-Akt signaling pathway Upregulation of miR-105 reduces hepatocellular carcinoma proliferation by downregulating the expression of PDK1 of PI3K-Akt signaling pathway.
 Shen et al., 2014
Hepatocellular carcinoma Hepatocyte Up HOXD10 RhoC pathway hsa-miR-10b acts as tumor metastatic factorin hepatocellular carcinoma cell through the HOXD10/ RhoC/ uPAR/ MMPs pathway.
 Liao et al., 2014
Hepatocellular carcinoma Hepatocyte Up RHOA RhoA pathway Overexpression of hsa-miR-122 downregulates RhoA, suppressing the RhoA pathway, enhancing cell adhesion and cell junction, impairing cytoskeletal events, and decreasing cell motility in hepatocellular carcinoma.
 Wang et al., 2014
Hepatocellular carcinoma Hepatocyte Down AKT mTOR pathway FoxD3-regulated miR-137 suppresses hepatocellular carcinoma cell growth and metastasis through inhibiting AKT2/mTOR pathway via targeting AKT2.
 Liu et al., 2014
Hepatocellular carcinoma Hepatocyte Down DNMT1 PI3K-Akt signaling pathway hsa-miR-185 acts as a tumor suppressor microRNA that prevents hepatocellular carcinoma cell growth by downregulating DNMT1, leading to PTEN induction and Akt inhibition.
 Qadir et al., 2014
Hepatocellular carcinoma Hepatocyte SMAD2 TGF-beta signaling pathway Overexpression of miR-148a inhibits the expression of SMAD2 and cancer stem cell-like properties in hepatocellular carcinoma cells throughTGF-beta signaling pathway.
 Jiang et al., 2014
Hepatocellular carcinoma Hepatocyte Down ITGB1 ITGB1 pathway MicroRNA-134 significantly suppresses hepatocellular carcinoma cell invasion and metastasis by targeting integrin beta-1. miR-134 also suppresses the phosphorylation of focal adhesion kinase and the activation of RhoA downstream of the ITGB1 pathway, thereby inhibiting stress fiber formation and cell adhesion in hepatocellular carcinoma cells.
 Zha et al., 2014
Hepatocellular carcinoma Hepatocyte Down TCF 4 Wnt signaling pathway Overexpression of miR-139 expression suppressess hepatocellular carcinoma cell proliferation and invasion via Wnt signaling pathway.
 Gu et al., 2014
Cervical cancer End1/E6E7 Up PI3K-Akt signaling pathway MicroRNA-181a functions as an oncogene in cervical cancer. Reduced expression of miR-181a is associated with enhanced expression of PTEN and decreased phosphorylation of Akt and FOXO1.
 Xu et al., 2016
Cervical cancer HaCaT Down SMAD3 miR-195/Smad3 pathway MicroRNA-195 inhibits migration and invasion of cervical cancer by targeting Smad3 expression.
 Zhou et al., 2016
Cervical cancer HeLa, Ca Ski PTEN NF-Kappa B signaling pathway Overexpression of microRNA-130a regulates cervical cancer cell growth by inhibiting phosphatase and tensin homolog expression.
 Feng et al., 2016
Cervical cancer HeLa, Ca Ski Down ABL2 miR-125a-5p/ABL2 pathway MicroRNA-125a regulates proliferation and migration of human cervical carcinoma by down-regulating ABL2 expression.
 Qin et al., 2016
Cervical cancer HeLa, SiHa Down CYCLIN D1 CDK pathway MiR-195 suppresses human cervical cancer cells proliferation by directly inhibiting cyclin D1 expression.
 Li et al., 2016
Cervical cancer HeLa, SiHa Down MCL1 ATR/Chk1 pathway MicroRNA-107 inhibits cervical cancer invasion through activating ATR/Chk1 pathway.
 Zhou et al., 2014
Cervical cancer C-33 A, HeLa AMOTL Vasculogenic mimicry pathway MicroRNA-124 inhibits vasculogenic mimicry, migration and invasion in cervical cancer by down-regulating the expression of AmotL1.
 Wan et al., 2014
Cervical cancer HeLa, Ca Ski, SiHa Up SIAH1 Beta-catenin pathway MicroRNA-135a promotes cervical cancer cell transformation via regulating miR-135a/SIAH1/beta-catenin signaling pathway.
 Leung et al., 2014
Cervical cancer HeLa, Ca Ski, SiHa Up FOXO1 PI3K-Akt signaling pathway MicroRNA-196a enhances cervical cancer proliferation through targeting FOXO1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Cervical cancer HeLa, Ca Ski, SiHa Up P27KIP1 PI3K-Akt signaling pathway MicroRNA-196a enhances cervical cancer proliferation through targeting p27Kip1, the key effector of the PI3K/Akt signaling pathway.
 Hou et al., 2014
Prostate cancer DU145, PC-3, 22Rv1, LNCap Down AEG 1 Wnt signaling pathway MicroRNA-1297 suppresses proliferation and invasion in prostate cancer by inhibiting AEG-1 expression.
 Liang et al., 2016
Prostate cancer LNCaP Down FNDC1 miRNA-1207-3p/FNDC1/FN1/AR regulatory pathway Over-expression of microRNA-1207 suppresses proliferation, migration, and promotes apoptosis through inhibiting FNDC1 expression.
 Das et al., 2016
Prostate cancer PC-3, DU145 Down EGFR EGFR signaling pathway Hsa-miR-135a-1 suppresses cell growth and migration of prostate cancer by down-regulating EGFR expression.
 Xu et al., 2016
Prostate cancer Prostate Down ROCK1 ROCK pathway MicroRNA-146a plays an important role in the process of androgen-independent prostate cancer cells apoptosis through regulation of ROCK pathway.
 Xu et al., 2015
Prostate cancer PC-3 Down SLAIN1 Apoptosis pathway Ectopic expression of microRNA-130a activates apoptotic signaling pathway in taxane-resistant prostate cancer cells via activation of caspase-8.
 Fujita et al., 2015
Prostate cancer DU145, PC-3, 22Rv1 Down TALIN 1 PI3K-Akt signaling pathway MicroRNA-124 inhibits cellular adhesion and motility by targeting talin1 via the focal adhesion kinase/PI3K-Akt signaling pathway.
 Zhang et al., 2015
Prostate cancer DU145, PC-3, 22Rv1 Down LAPTM4B PI3K-Akt signaling pathway Overexpression of miR-188 suppresses the PI3K-Akt signaling pathway through the inhibition of LAPTM4B.
 Zhang et al., 2015
Prostate cancer DU145, BPH-1 PACE4 PACE4 pathway MicroRNA-124 shows antiproliferative and antiaggressive effects by inhibiting PACE4 expression in prostate cancer.
 Kang et al., 2014
Ovarian cancer SK-OV-3, OVCAR3, HO-8910 Up EGFR PI3K-Akt signaling pathway Upregulation of miR-133b suppresses proliferation and invasion of ovarian cancer cells through inhibition PI3K-Akt signaling pathways by down-regulating EGFR expression.
 Liu et al., 2015
Ovarian cancer A2780, SK-OV-3, COV362 Up SFRP1 Wnt signaling pathway MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting SFRP1 by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer A2780, SK-OV-3, COV362 Up AXIN2 Wnt signaling pathway MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting AXIN2 by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer A2780, SK-OV-3, COV362 Up ICAT Wnt signaling pathway MicroRNA-1207 plays an important role in regulating the cancer stem cell-like phenotype through targeting ICAT by activating the Wnt signaling pathway in ovarian cancer.
 Wu et al., 2015
Ovarian cancer A2780, SK-OV-3, OVCAR Down PDGFRA miR-140-5p-PDGFRA pathway Upregulation of miR-140 significantly suppresses ovarian cancer cell proliferation and promotes apoptosis by targeting PDGFRA.
 Lan et al., 2015
Ovarian cancer SK-OV-3, SNU-119 Down PI3K-Akt signaling pathway Decreased expression of miRNA-150 regulates the pertuzumab resistance in ovarian cancer through PI3K-Akt signaling pathway.
 Wuerkenbieke et al., 2015
Ovarian cancer A2780, SK-OV-3, OVCAR, Caov-3 YAP Hippo signaling pathway MicroRNA-129 suppresses ovarian cancer cell proliferation, survival and tumorigenicity by down-regulating YAP expression.
 Tan et al., 2015
Ovarian cancer Ovary Up NLK Wnt signaling pathway MicroRNA-197 promotes Taxol resistance in human ovarian cancer cells by down-regulating NLK expression.
 Zou et al., 2015
Ovarian cancer A2780 KEAP1 NF-Kappa B signaling pathway MicroRNA-141 down-regulates KEAP1 expression, and decreased expression of KEAP1 promotes cisplatin resistance in ovarian cancer.
 Jaarsveld et al., 2013
Bladder cancer BLS-1 Up PIK3R2 PI3K-Akt signaling pathway Upregulation of miR-126 inhibits proliferation, migration, and invasion and enhances apoptosis by down-regulating PIK3R2 expression through regulating PI3K-Akt signaling pathway in bladder cancer.
 Xiao et al., 2016
Bladder cancer UM-UC-3, T24 Up DMTF1 p53 signaling pathway MicroRNA-155 acts as a tumor promoter by inhibiting DMTF1 expression in bladder cancer.
 Peng et al., 2015
Bladder cancer 5637 HOXC9 Oxidative stress pathway MicroRNA-193a enhances the multi-chemoresistance of bladder cancer by down-regulating the HOXC9 expression.
 Lv et al., 2015
Bladder cancer UM-UC-3, T24, 5637 Up LOXL4 Oxidative stress pathway MicroRNA-193a induces the multi-chemoresistance of bladder cancer cells by down-regulating lysyl oxidase-like 4 (LOXL4) expression.
 Deng et al., 2014
Bladder cancer T24 Down COX-2 COX-2 pathway MicroRNA-101 regulates cisplatin resistance in bladder cancer by targeting the COX-2 pathway.
 Bu et al., 2014
Bladder cancer RT-4, T24, DSH1 Down EZH2 Wnt signaling pathway Decreased expression of miR-144 enhances bladder cancer proliferation by down-regulating EZH2 expression through activation of Wnt signaling pathway.
 Guo et al., 2014
Bladder cancer UM-UC-3, T24 Up RECK Wnt signaling pathway MicroRNA-182 functions as an oncogene by targeting RECK through activation of the Wnt signaling pathway in bladder cancer.
 Hirata et al., 2012
Bladder cancer UM-UC-3, T24 Up SMAD4 Wnt signaling pathway MicroRNA-182 functions as an oncogene by targeting Smad4 through activation of the Wnt signaling pathway in bladder cancer.
 Hirata et al., 2012
Nasopharyngeal carcinoma CNE-2, HONE1 Down S1PR1 Jak-STAT signaling pathway MicroRNA-133b inhibits proliferation of nasopharyngeal carcinoma cell by down-regulating S1PR1 expression.
 Cheng et al., 2016
Nasopharyngeal carcinoma HNE-1 Up PTEN PI3K-Akt signaling pathway MicroRNA-141 promotes cell proliferation and tumor formation in nasopharyngeal carcinoma through targeting PI3K-Akt signaling pathway.
 Liu et al., 2016
Nasopharyngeal carcinoma CNE-2 Down STMN1 miR-101/STMN1 pathway MicroRNA-101 regulates cell viability, radioresistance and radiation-induced autophagy by down-regulating stathmin 1 expression in nasopharyngeal carcinoma.
 Sun et al., 2015
Nasopharyngeal carcinoma CNE-2 Down WNT2B Wnt signaling pathway MicroRNA-185 controls the radioresistance of nasopharyngeal carcinoma through targeting WNT2B expression.
 Li et al., 2014
Laryngeal squamous cell carcinoma HEp-2, AMC-HN-8 Up FOXO1 PI3K-Akt signaling pathway MicroRNA-132 functions as an oncogene in laryngeal squamous cell carcinoma by regulating the PI3K-Akt signaling pathway.
 Lian et al., 2016
Laryngeal squamous cell carcinoma HEp-2 Down IRS1 PI3K-Akt signaling pathway MicroRNA-144 acts as a tumor suppressor in laryngeal squamous cell carcinoma by down-regulating IRS1 expression.
 Wu et al., 2016
Laryngeal squamous cell carcinoma HEp-2 Up TIMP2 TIMP-2 pathway MicroRNA-19a functions as an oncogene in the progression of laryngeal squamous cell carcinoma by targeting TIMP-2 expression.
 Wu etal., 2013
Oral squamous cell carcinoma SCC-9, SCC-25, Down AGK PI3K-Akt signaling pathway MicroRNA-194 acts as a potential tumor suppressor by targeting the PI3K-Akt signaling pathway.
 Chi et al., 2015
Thyroid carcinoma Thyroid gland Down ER ALPHA Estrogen signaling pathway MicroRNA-1280 functions as a tumor suppressor by down-regulating ER-alpha expression.
 Meng et al., 2016
Papillary thyroid carcinoma TPC-1, B-CPAP Up SMAD4 TGF-beta signaling pathway MicroRNA-146b regulates migration and invasion in papillary thyroid carcinoma by targeting SMAD4, a key protein in theTGF-beta signaling pathway.
 Lima et al., 2016
Papillary thyroid carcinoma TPC-1, K1 Down LRP6 Wnt signaling pathway MicroRNA-126 acts as a tumor-suppressive microRNA by down-regulating LRP6 expression through Wnt signaling pathway.
 Wen et al., 2015
Medullary thyroid carcinoma MZ-CRC-1, TT Down RET RET pathway MicroRNA-129 regulates the growth, apoptosis and migration of medullary thyroid carcinoma cells through down-regulating RET expression.
 Duan et al., 2014
Follicular thyroid carcinoma Thyroid gland PTK6 ERK pathway MicroRNA-17 suppresses the S1P-induced cell migration in follicular thyroid carcinoma through the ERK pathway.
 Zhao et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3 Up Hippo signaling pathway Over-expression of miR-181c inactivates the Hippo signaling pathway in pancreatic carcinoma.
 Chen et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1, Capan-2 Down STAT3 Jak-STAT signaling pathway MicroRNA-1181 downregulates STAT3 expression, resulting in inhibition of the Jak-STAT signaling pathway in pancreatic cancer.
 Jiang et al., 2015
Pulmonary arterial hypertension Lung Up GSK 3 BETA Wnt signaling pathway Overexpression of miR-199b in hypoxic pulmonary arterial epithelial cells downregulates GSK3B expression.
 Wu et al., 2016
Asthma Airway smooth muscle PDK1 PI3K-Akt signaling pathway hsa-miR-138 controls ASMC proliferation through directly suppressing the PI3K-Akt signaling pathway.
 Liu et al., 2015
Asthma Bronchial epithelial cell Up TGFBR2 TGF-beta signaling pathway hsa-miR-19a increased bronchial epithelial cell proliferation in severe asthma through inhibiting TGF-beta receptor 2 mRNA level.
 Haj-salem et al., 2015
Asthma Airway smooth muscle Up PIK3CA PI3K-Akt signaling pathway MicroRNA-10a regulates human airway smooth muscle cell proliferation through targeting PI3K-Akt signaling pathway.
 Hu et al., 2014
Pulmonary arterial hypertension Right ventricular Down SPRED1 VEGF signaling pathway Decreased expression of miR-126 is associated with increased Sprouty-related EVH1 domain-containing protein 1 (SPRED-1) expression, leading to decreased activation of RAF and MAPK, thus inhibiting the vascular endothelial growth factor pathway.
 Potus et al., 2015
Myocarditis Myocardial Up REL A NF-Kappa B signaling pathway hsa-miR-155 reduces cardiac injury by repressing NF-Kappa B signaling pathway during acute viral myocarditis.
 Bao et al., 2014
Myocarditis Myocardial Up REL A NF-Kappa B signaling pathway hsa-miR-148a reduces cardiac injury by repressing NF-Kappa B signaling pathway during acute viral myocarditis.
 Bao et al., 2014
Heart failure Left ventricular Up TGFBR1 TGF-beta signaling pathway Overexpression of hsa-miR-15 inhibits TGF-beta signaling pathway through downregulating the expression of TGFBR1.
 Tijsen et al., 2014
Myocarditis HeLa Up SPRED1 ERK pathway MicroRNA-126 activates ERK pathway through targeting SPRED1 and enhances CVB3 replication.
 Ye et al., 2013
Myocarditis HeLa Up LRP6 Wnt signaling pathway hsa-miR-126 expression promotes GSK-3-beta activity and induces degradation of beta-catenin through inhibiting LRP6, the targets in the Wnt signaling pathway.
 Ye et al., 2013
Myocarditis HeLa Up WRCH1 Wnt signaling pathway hsa-miR-126 expression promotes GSK-3-beta activity and induces degradation of beta-catenin through inhibiting WRCH1, the targets in the Wnt signaling pathway.
 Ye et al., 2013
Psoriasis HaCat Up PTEN PTEN pathway Decreased expression of miR-155 significantly inhibits proliferation, migration, invasion and promotes apoptosis through PTEN singaling pathway in psoriasis cells.
 Xu et al., 2017
Psoriasis HaCat Up AKT PTEN pathway MicroRNA-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. Expression of apoptosis related factor AKT is dramatically changed.
 Xu et al., 2017
Psoriasis HaCat Up BCL 2 PTEN pathway Hsa-miR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway through targeting BCL 2 in the psoriasis.
 Xu et al., 2017


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024