| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Gastric cancer tissue | Up | p53 signaling pathway | MicroRNA-100 antagonism suppresses ubiquitin-mediated p53 protein degradation by activating RNF144B, an E3 ubiquitination ligase. | Yang et al., 2016 | |
| Gastric cancer | MGC-803, HGC-27, GES-1 | Up | HS3ST2 | Notch signaling pathway | Antagonism of miR-100 enhances the expression level of HS3ST2, results in the activation of the Notch-apoptosis pathway in tumor cells. | Yang et al., 2015 |
| Chondrosarcoma | CHON-001 | Down | MTOR | mTOR pathway | MicroRNA-100 functions as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance through down-regulating the expression of mTOR. | Zhu et al., 2014 |
| Breast cancer | Breast | Down | FZD8 | Wnt signaling pathway | MicroRNA-100 inhibits the migration and invasion of breast cancer cells by down-regulating FZD-8 and suppressing Wnt signaling pathway. | Jiang et al., 2016 |