Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Gastric cancer | MKN28, MKN45, AGS | Down | MTOR | PI3K-Akt signaling pathway | MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of mTOR in gastric cancer. | Riquelme et al., 2016 |
Breast cancer | Breast | Down | EYA1 | Notch signaling pathway | MicroRNA-101 suppresses cell proliferation and promote apoptosis in breast cancer by down-regulating EYA1 via the Notch signaling pathway. | Guan et al., 2016 |
Laryngeal squamous cell carcinoma | Lung | CDK8 | Wnt signaling pathway | MicroRNA-101 acts as a tumour repressor that directly suppresses CDK8 expression in laryngeal squamous cell carcinoma. | Li et al., 2015 | |
Bladder cancer | T24 | Down | COX-2 | COX-2 pathway | MicroRNA-101 regulates cisplatin resistance in bladder cancer by targeting the COX-2 pathway. | Bu et al., 2014 |
Nasopharyngeal carcinoma | CNE-2 | Down | STMN1 | miR-101/STMN1 pathway | MicroRNA-101 regulates cell viability, radioresistance and radiation-induced autophagy by down-regulating stathmin 1 expression in nasopharyngeal carcinoma. | Sun et al., 2015 |