| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | MKN-45,GES-1 | Up | HOXD10 | PI3K-Akt signaling pathway | MicroRNA-10b promotes the phosphorylation of RhoC and AKT through down-regulating HOXD10, thus enhancing cell invasion in gastric tumors. | Liu et al., 2012 |
| Breast cancer | Breast | Up | NF1 | ROCK pathway | MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting NF1. | Knirsh et al., 2016 |
| Breast cancer | Breast | Up | HOXD10 | ROCK pathway | MicroRNA-10b affects cytoskeletal dynamics via the ROCK pathway through targeting HOXD10. | Knirsh et al., 2016 |
| Breast cancer | MCF-7,MDA-MB-231, SK-BR-3 | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-10b regulates the self-renewal of the breast cancer stem cell phenotype through PI3K-Akt signaling pathway by targeting PTEN. | Bahena-Ocampo et al., 2016 |
| Hepatocellular carcinoma | Hepatocyte | Up | HOXD10 | RhoC pathway | hsa-miR-10b acts as tumor metastatic factorin hepatocellular carcinoma cell through the HOXD10/ RhoC/ uPAR/ MMPs pathway. | Liao et al., 2014 |