microRNA Name:

hsa-miR-122

Gene Score: 0.0213

Pathway Score: 0.0574

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Cutaneous T-cell lymphoma MyLa, Se-Ax Up PI3K-Akt signaling pathway Overexpression of hsa-miR-122 decreases the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53.
Manfe et al., 2012
Hepatitis C virus infection Hep-G2 HCBP6 SREBP pathway Over-expression of microRNA-122 suppresses the expression of HCBP6 (hepatitis C virus core-binding protein 6) which modulates TG (Triglyceride) Homeostasis in Hepatocytes through the SREBP pathway.
Gao et al., 2015
Hepatitis C virus RNA abundance Hepatocyte Isoprenoid biosynthesis pathway MicroRNA-122 modulates viral RNA abundance independently of its effect on isoprenoid metabolism.
Norman et al., 2010
Gastric cancer MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 Down IRS1 Beta-catenin pathway MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway.
Zheng et al., 2016
Non-small cell lung cancer Lung Down PI3K-Akt signaling pathway MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor.
Qin et al., 2015
Breast cancer Breast Up GSK 3 BETA Wnt signaling pathway MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway.
Tan et al., 2016
Hepatocellular carcinoma HUVEC TGFBR1 TGF-beta signaling pathway Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1.
Yin et al., 2016
Hepatocellular carcinoma PLC/PRF/5 - PDK4 Glycolysis pathway miR-122 inhibits hepatocellular cancer stem cells phenotypes by regulating glycolysis via down-reguating PDK4.
Song et al., 2015
Hepatocellular carcinoma Hepatocyte Up RHOA RhoA pathway Overexpression of hsa-miR-122 downregulates RhoA, suppressing the RhoA pathway, enhancing cell adhesion and cell junction, impairing cytoskeletal events, and decreasing cell motility in hepatocellular carcinoma.
Wang et al., 2014