Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Cutaneous T-cell lymphoma | MyLa, Se-Ax | Up | PI3K-Akt signaling pathway | Overexpression of hsa-miR-122 decreases the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53. | Manfe et al., 2012 | |
Hepatitis C virus infection | Hep-G2 | HCBP6 | SREBP pathway | Over-expression of microRNA-122 suppresses the expression of HCBP6 (hepatitis C virus core-binding protein 6) which modulates TG (Triglyceride) Homeostasis in Hepatocytes through the SREBP pathway. | Gao et al., 2015 | |
Hepatitis C virus RNA abundance | Hepatocyte | Isoprenoid biosynthesis pathway | MicroRNA-122 modulates viral RNA abundance independently of its effect on isoprenoid metabolism. | Norman et al., 2010 | ||
Gastric cancer | MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 | Down | IRS1 | Beta-catenin pathway | MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway. | Zheng et al., 2016 |
Non-small cell lung cancer | Lung | Down | PI3K-Akt signaling pathway | MicroRNA-122 inhibits the epithelial-mesenchymal transition process by suppressing PI3K/AKT activation through decreasing endogenous expression of insulin-like growth factor 1 receptor. | Qin et al., 2015 | |
Breast cancer | Breast | Up | GSK 3 BETA | Wnt signaling pathway | MicroRNA-1229 plays an important role in proliferation and tumorigenecity in breast cancer through activating Wnt signaling pathway. | Tan et al., 2016 |
Hepatocellular carcinoma | HUVEC | TGFBR1 | TGF-beta signaling pathway | Over-expression of TGF-beta1 is associated with poor survival in human primary liver tumours. hsa-miR-122 directly targets TGF-beta1. | Yin et al., 2016 | |
Hepatocellular carcinoma | PLC/PRF/5 | - | PDK4 | Glycolysis pathway | miR-122 inhibits hepatocellular cancer stem cells phenotypes by regulating glycolysis via down-reguating PDK4. | Song et al., 2015 |
Hepatocellular carcinoma | Hepatocyte | Up | RHOA | RhoA pathway | Overexpression of hsa-miR-122 downregulates RhoA, suppressing the RhoA pathway, enhancing cell adhesion and cell junction, impairing cytoskeletal events, and decreasing cell motility in hepatocellular carcinoma. | Wang et al., 2014 |