| B-cell lymphoma |
|
Down |
MYC |
NF-Kappa B signaling pathway |
Ectopic expression of p53 increases the miR-124 levels and suppresses MYC. Disruption of NF-Kappa B signaling pathway may be associated with abnormal coexpression of MYC and poor prognosis in B-cell lymphoma. |
Jeong et al., 2015 |
| B-cell lymphoma |
|
Down |
BCL2 |
NF-Kappa B signaling pathway |
Ectopic expression of p53 increases the miR-124 levels and suppresses BCL2. Disruption of NF-Kappa B signaling pathway may be associated with abnormal coexpression of BCL2 and poor prognosis in B-cell lymphoma. |
Jeong et al., 2015 |
| Diffuse Large B-cell lymphoma |
OCI-Ly1, OCI-Ly18, SU-DHL-7 |
Up |
PDE4B |
PI3K-Akt signaling pathway |
MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the PI3K-Akt signaling pathway in diffuse large B cell lymphoma. |
Kim et al., 2015 |
| Diffuse Large B-cell lymphoma |
OCI-Ly1, OCI-Ly18, SU-DHL-7 |
Up |
PDE4B |
mTOR pathway |
MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the mTOR pathway in diffuse large B cell lymphoma. |
Kim et al., 2015 |
| Diffuse Large B-cell lymphoma |
OCI-Ly1, OCI-Ly18, SU-DHL-7 |
Up |
PDE4B |
MCL1 pathway |
MicroRNA-124 controls glucocorticoid sensitivity by down regulating phosphodiesterase 4B (PDE4B). This is associated with increased cAMP levels, suppression of the MCL1 pathway in diffuse large B cell lymphoma. |
Kim et al., 2015 |
| Acute lymphoblastic leukemia |
TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat |
Down |
CDK6 |
CDK pathway |
Down-regulation of miR-124a promotes up-regulation of its target, CDK6, and phosphorylation of retinoblastoma (Rb) and contributes to the abnormal proliferation of acute lymphoblastic leukemia cells. |
Agirre et al., 2009 |
| Non-small cell lung cancer |
Lung |
Down |
SMAD4 |
TGF-beta signaling pathway |
The feedback loop between miR-124 and TGF-beta signaling pathway play an important role in non-small cell lung cancer metastasis. |
Zu et al., 2016 |
| Breast cancer |
Breast |
Down |
AKT |
Estrogen signaling pathway |
Upregulation of miR-124 inhibits tumor growth and angiogenesis in breast cancer by inhibiting AKT2 expression. |
Jiang et al., 2016 |
| Hepatocellular carcinoma |
Hepatocyte |
|
NFIB |
p53 signaling pathway |
p53 controls the expression of hsa-miR-1246 in hepatocellular carcinoma. hsa-miR-1246 directly targets nuclear factor I/B (NFIB). Overexpression of hsa-miR-1246 promotes cell proliferation, colony formation and apoptosis through modulating p53 signaling pathway in hepatocellular carcinoma. |
Zhang et al., 2015 |
| Cervical cancer |
C-33 A, HeLa |
|
AMOTL |
Vasculogenic mimicry pathway |
MicroRNA-124 inhibits vasculogenic mimicry, migration and invasion in cervical cancer by down-regulating the expression of AmotL1. |
Wan et al., 2014 |
| Prostate cancer |
DU145, PC-3, 22Rv1 |
Down |
TALIN 1 |
PI3K-Akt signaling pathway |
MicroRNA-124 inhibits cellular adhesion and motility by targeting talin1 via the focal adhesion kinase/PI3K-Akt signaling pathway. |
Zhang et al., 2015 |
| Prostate cancer |
DU145, BPH-1 |
|
PACE4 |
PACE4 pathway |
MicroRNA-124 shows antiproliferative and antiaggressive effects by inhibiting PACE4 expression in prostate cancer. |
Kang et al., 2014 |