| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Stomach | Down | ERBB2 | ErbB signaling pathway | MicroRNA-125a inhibits the proliferation of gastric cancer cells through targeting ERBB2. | Nishida et al., 2011 |
| Breast cancer | MCF-7, MCF-10A, MCF-12A, MDA-MB-231 | Up | LIFR | Hippo signaling pathway | MicroRNA-125a influences breast cancer stem cells by regulating Hippo signaling through targeting LIFR. | Nandy et al., 2015 |
| Hepatocellular carcinoma | Hep-G2, LM3 | Down | PI3K | PI3K-Akt signaling pathway | MicroRNA-125a directly targets PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway. | Tang et al., 2015 |
| Hepatocellular carcinoma | Hep-G2, LM3 | Down | AKT | PI3K-Akt signaling pathway | MicroRNA-125a down-regulates the expression of PI3K. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway. | Tang et al., 2015 |
| Hepatocellular carcinoma | Hep-G2, LM3 | Down | MTOR | PI3K-Akt signaling pathway | Over-expression of microRNA-125a inhibits the expression of mTOR. Upregulation of MicroRNA-125a suppresses the invasive ability of hepatocellular carcinoma cells through regulation of the PI3K-Akt signaling pathway. | Tang et al., 2015 |
| Cervical cancer | HeLa, Ca Ski | Down | ABL2 | miR-125a-5p/ABL2 pathway | MicroRNA-125a regulates proliferation and migration of human cervical carcinoma by down-regulating ABL2 expression. | Qin et al., 2016 |