| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| T-cell leukemia | Jurkat cell | Up | FADD | Fas signaling pathway | Ectopic expression of miR-128a confers Fas-resistance by directly suppressing Fas-associated protein with death domain (FADD). | Yamada et al., 2014 |
| Multiple sclerosis | COS-7 | Up | TGFBR1 | TGF-beta signaling pathway | Over-expression of miR-128 directly targets TGFBR1. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Over-expression of miR-128 suppresses the expression of SMAD4. MicroRNA-128 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Lung cancer | A-549, SPC-A1, NCI-H460, NCI-H1299 | PFKL | PI3K-Akt signaling pathway | Upregulation of miR-128 down-regulates phosphofructokinase liver type (PFKL) through a feedback loop that involves suppression of the AKT signaling pathway. | Yang et al., 2016 | |
| Hepatocellular carcinoma | Hepatocyte | Down | PIK3R1 | PI3K-Akt signaling pathway | Overexpression of hsa-miR-128 suppress HCC cell proliferation by regulating PIK3R1 expression and PI3K-Akt signaling pathway. | Huang et al., 2015 |
| Thyroid carcinoma | Thyroid gland | Down | ER ALPHA | Estrogen signaling pathway | MicroRNA-1280 functions as a tumor suppressor by down-regulating ER-alpha expression. | Meng et al., 2016 |