Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Chronic lymphocytic leukemia | Peripheral blood | Up | SIRT1 | p53 signaling pathway | Up-regulation of hsa-miR-132 down-regulates the expression of SIRT1 and induces TP53-dependent apoptosis in chronic lymphocytic leukemia. | Dal et al., 2015 |
Alzheimer's disease | Cerebral cortex | Down | PTEN | PI3K-Akt signaling pathway | MicroRNA-132 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
Alzheimer's disease | Cerebral cortex | Down | FOXO3A | FoxO signaling pathway | MicroRNA-132 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
Hepatocellular carcinoma | Hep-G2, SMMC-7721, Huh-7 | Down | PIK3R3 | mTOR pathway | Overexpression hsa-miR-132 inhibits PIK3R3 expression. miR-132 suppresses proliferation, invasion and migration of HCC through inactivating AKT/mTOR pathway | Liu et al., 2015 |
Laryngeal squamous cell carcinoma | HEp-2, AMC-HN-8 | Up | FOXO1 | PI3K-Akt signaling pathway | MicroRNA-132 functions as an oncogene in laryngeal squamous cell carcinoma by regulating the PI3K-Akt signaling pathway. | Lian et al., 2016 |