| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | Hepatocyte | Down | AKT | PI3K-Akt signaling pathway | Upregulation of miR-133a suppresses the activation of AKT signal pathway, which contributes to inhibition of hepatocellular carcinoma (HCC) cell growth. MicroRNA-133a acts as a tumor suppressor and represses survival of HCC cells by down-regulating IGF-1R. | Zhang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | ERK | ERK pathway | MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth. | Zhang et al., 2015 |
| Gastric cancer | Stomach | Down | CDC42 | CDC42 pathway | MicroRNA-133 acts as a negative regulator of CDC42 pathway in gastric cancer. | Cheng et al., 2014 |
| Hepatocellular carcinoma | Hepatocyte | Down | IGF 1R | PI3K-Akt signaling pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | IGF 1R | ERK pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |
| Ovarian cancer | SK-OV-3, OVCAR3, HO-8910 | Up | EGFR | PI3K-Akt signaling pathway | Upregulation of miR-133b suppresses proliferation and invasion of ovarian cancer cells through inhibition PI3K-Akt signaling pathways by down-regulating EGFR expression. | Liu et al., 2015 |
| Nasopharyngeal carcinoma | CNE-2, HONE1 | Down | S1PR1 | Jak-STAT signaling pathway | MicroRNA-133b inhibits proliferation of nasopharyngeal carcinoma cell by down-regulating S1PR1 expression. | Cheng et al., 2016 |