| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | Hepatocyte | Down | AKT | PI3K-Akt signaling pathway | Upregulation of miR-133a suppresses the activation of AKT signal pathway, which contributes to inhibition of hepatocellular carcinoma (HCC) cell growth. MicroRNA-133a acts as a tumor suppressor and represses survival of HCC cells by down-regulating IGF-1R. | Zhang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | ERK | ERK pathway | MicroRNA-133a acts as a tumor suppressor and represses survival of hepatocellular carcinoma (HCC) cells by down-regulating IGF-1R. Upregulation of miR-133a suppresses the activation of ERK signal pathway, which contributes to inhibition of HCC cell growth. | Zhang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | IGF 1R | PI3K-Akt signaling pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | IGF 1R | ERK pathway | hsa-miR-133a suppress tumor growth in hepatocellular carcinoma by targeting IGF-1R via regulating AKT and ERK signaling pathway. Mir-133a acts as a tumor suppressor. | Zhang et al., 2015 |